Version: 8.0.0Date: Tue Jan 28 2025
Gene Biological Process: telomere maintenance Molecular Function: small molecule binding
ATM
(Homo sapiens)Gene
Name: ATM serine/threonine kinase
Synonyms: serine/threonine kinase ATM, TEL1, telomere maintenance 1, homolog, MGC74674, human phosphatidylinositol 3-kinase homolog, ATDC, truncated ATM serine/threonine kinase, DKFZp781A0353, ATA, AT mutated, ATC, ataxia telangiectasia mutated, ATD, TEL1, ataxia telangiectasia mutated (includes complementation groups A, C and D), ATE, A-T mutated, serine-protein kinase ATM, TELO1, AT1
Source: HGNC:795
Biotype: protein coding gene
MRE11
(Homo sapiens)Gene
Name: MRE11 homolog, double strand break repair nuclease
Synonyms: HNGS1, double-strand break repair protein MRE11A, MRE11 homolog A, DNA recombination and repair protein, MRE11A, MRE11B, endo/exonuclease Mre11, meiotic recombination 11 homolog A, double-strand break repair protein MRE11, MRE11 meiotic recombination 11-like protein A, MRE11 homolog A, double strand break repair nuclease, MRE11 meiotic recombination 11 homolog A, ATLD, AT-like disease, MRE11 homolog 1, MRE11 double strand break repair nuclease A, MRE11 homolog, double strand break repair nuclease A, meiotic recombination 11 homolog 1
Source: HGNC:7230
Biotype: protein coding gene
HSPA1A
(Homo sapiens)Gene
Name: heat shock protein family A (Hsp70) member 1A
Synonyms: HSP70-2, HSP70-1, epididymis secretory protein Li 103, HSP70-1A, FLJ54303, FLJ75127, FLJ54408, heat shock 70kD protein 1A, heat shock 70 kDa protein 1/2, HSP70.1/HSP70.2, HSP70I, heat shock-induced protein, HSP72, dnaK-type molecular chaperone HSP70-1, HSP70.2, HSP70.1, HSP70, heat shock 70 kDa protein 1A, Heat shock 70 kDa protein 1B, HEL-S-103, HSPA1, heat shock 70kDa protein 1A, HSP70-1/HSP70-2, Heat shock 70 kDa protein 2, heat shock 70 kDa protein 1A/1B, heat shock 70 kDa protein 1, FLJ54392, FLJ54370, heat shock protein family A member 1A, HSPA1B
Source: HGNC:5232
Biotype: protein coding gene
SGS1
(Saccharomyces cerevisiae)Gene
Name: Slow Growth Suppressor
Synonyms: YMR190C
Source: SGD:S000004802
Biotype: protein coding gene
ATR
(Homo sapiens)Gene
Name: ATR serine/threonine kinase
Synonyms: FRAP-related protein 1, MEC1, ataxia telangiectasia and Rad3-related protein, MEC1, mitosis entry checkpoint 1, homolog, ataxia telangiectasia and Rad3 related, FRAP-related protein-1, FRP1, SCKL1, serine/threonine-protein kinase ATR, protein kinase ATR, SCKL, Rad3 related protein, FCTCS
Source: HGNC:882
Biotype: protein coding gene
DNA2
(Homo sapiens)Gene
Name: DNA replication helicase/nuclease 2
Synonyms: RTS4, MGC133297, DNA replication helicase 2 homolog, PEOA6, DNA2 (DNA replication helicase, yeast, homolog)-like, DNA2 DNA replication helicase 2-like, KIAA0083, FLJ10063, DNA replication ATP-dependent helicase/nuclease DNA2, DNA2L, DNA2-like helicase, SCKL8, hDNA2, DNA replication ATP-dependent helicase-like homolog
Source: HGNC:2939
Biotype: protein coding gene
PIF1
(Homo sapiens)Gene
Name: PIF1 5'-to-3' DNA helicase
Synonyms: ATP-dependent DNA helicase PIF1, DNA helicase PIF1, PIF1/RRM3 DNA helicase-like protein, petite integration frequency 1, C15orf20, PIF1 5'-to-3' DNA helicase homolog, chromosome 15 open reading frame 20, DNA helicase homolog PIF1, PIF1 DNA helicase, DNA repair and recombination helicase PIF1, PIF
Source: HGNC:26220
Biotype: protein coding gene
TEL1
(Saccharomyces cerevisiae)Gene
Name: TELomere maintenance
Synonyms: YBL088C
Source: SGD:S000000184
Biotype: protein coding gene
APEX1
(Homo sapiens)Gene
Name: apurinic/apyrimidinic endodeoxyribonuclease 1
Synonyms: DNA repair nuclease/redox regulator APEX1, redox factor-1, multifunctional DNA repair enzyme, deoxyribonuclease (apurinic or apyrimidinic), AP endonuclease 1, DNA-(apurinic or apyrimidinic site) lyase, APE1, APEN, DNA-(apurinic or apyrimidinic site) endonuclease, apurinic-apyrimidinic endonuclease 1, APX, apurinic/apyrimidinic exonuclease, AP lyase, AP endonuclease class I, APE, APEX nuclease (multifunctional DNA repair enzyme) 1, apurinic/apyrimidinic (abasic) endonuclease, REF1, HAP1, protein REF-1, APEX, redox factor 1
Source: HGNC:587
Biotype: protein coding gene
TERT
(Homo sapiens)Gene
Name: telomerase reverse transcriptase
Synonyms: TP2, TRT, telomerase-associated protein 2, PFBMFT1, CMM9, telomerase catalytic subunit, TCS1, EST2, DKCA2, hEST2, hTRT, DKCB4
Source: HGNC:11730
Biotype: protein coding gene
HSP90AB1
(Homo sapiens)Gene
Name: heat shock protein 90 alpha family class B member 1
Synonyms: heat shock protein 90kDa alpha family class B member 1, HSP 90, FLJ26984, D6S182, heat shock protein family C member 3, HSP 84, heat shock protein HSP 90-beta, HSP90 beta, HSPC2, heat shock 84 kDa, 90-kda heat shock protein beta, HSP90B, heat shock protein beta, HSPCB, HSP90-BETA, heat shock 90kD protein 1, beta, heat shock protein 90 kDa, HSP84, 90-kda heat shock protein beta HSP90 beta, heat shock protein 90kDa alpha (cytosolic), class B member 1
Source: HGNC:5258
Biotype: protein coding gene
RAD50
(Homo sapiens)Gene
Name: RAD50 double strand break repair protein
Synonyms: hRad50, DNA repair protein RAD50, RAD502, RAD50-2, RAD50 homolog, NBSLD
Source: HGNC:9816
Biotype: protein coding gene
PPP1CA
(Homo sapiens)Gene
Name: protein phosphatase 1 catalytic subunit alpha
Synonyms: PP-1A, testicular tissue protein Li 155, MGC1674, PP1A, serine/threonine protein phosphatase PP1-alpha 1 catalytic subunit, PP1alpha, PPP1A, serine/threonine-protein phosphatase PP1-alpha catalytic subunit, MGC15877, protein phosphatase 1, catalytic subunit, alpha isoform
Source: HGNC:9281
Biotype: protein coding gene
HSP90AA1
(Homo sapiens)Gene
Name: heat shock protein 90 alpha family class A member 1
Synonyms: heat shock 86 kDa, heat shock protein family C member 1, HSP90N, HSPCAL1, heat shock 90kDa protein 1, alpha, HSPCAL4, HEL-S-65p, heat shock 90kD protein 1, alpha-like 4, epididymis luminal secretory protein 52, HSP89A, HSP 86, Hsp89, FLJ31884, Hsp103, lipopolysaccharide-associated protein 2, Hsp90, heat shock protein 90kDa alpha (cytosolic), class A member 1, HSP90A, heat shock protein 90kDa alpha family class A member 1, HSPCA, LPS-associated protein 2, heat shock protein HSP 90-alpha, EL52, heat shock 90kD protein 1, alpha, HSPN, LAP-2, HSPC1, renal carcinoma antigen NY-REN-38, LAP2, heat shock 90kD protein, alpha-like 4, heat shock 90kDa protein 1, alpha-like 4, epididymis secretory sperm binding protein Li 65p, HSP86
Source: HGNC:5253
Biotype: protein coding gene
Parp1
(Mus musculus)Gene
Name: poly (ADP-ribose) polymerase family, member 1
Synonyms: poly (ADP-ribose) polymerase, Adprt1, Parp-1, expressed sequence AI893648, Adprp, PARP, ARTD1, sPARP-1, Adprt, AI893648, RIKEN cDNA 5830444G22 gene, parp-1, 5830444G22Rik, C80510, expressed sequence C80510, ADP-ribosyltransferase (NAD+, poly (ADP-ribose) polymerase) 1
Source: MGI:1340806
Biotype: protein coding gene
Prkdc
(Mus musculus)Gene
Name: protein kinase, DNA activated, catalytic polypeptide
Synonyms: DNAPDcs, DNA-PKcs, doxorubicin nephropathy, XRCC7, DNA-PK, expressed sequence AI326420, AU019811, dxnph, severe combined immunodeficiency, DOXNPH, expressed sequence AU019811, slip, AI326420, scid
Source: MGI:104779
Biotype: protein coding gene
WRN
(Homo sapiens)Gene
Name: WRN RecQ like helicase
Synonyms: RECQ3, RECQL3, Werner syndrome RecQ like helicase, bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, Werner syndrome, RecQ helicase-like, recQ protein-like 2, exonuclease WRN, DNA helicase, RecQ-like type 3, DKFZp686C2056, RECQL2, Werner syndrome ATP-dependent helicase
Source: HGNC:12791
Biotype: protein coding gene
BLM
(Homo sapiens)Gene
Name: BLM RecQ like helicase
Synonyms: MGRISCE1, Bloom syndrome RecQ like helicase, MGC131620, recQ-like DNA helicase BLM, Bloom syndrome, RecQ helicase-like, MGC126616, RECQL3, BS, RECQ2, Bloom syndrome protein, recQ protein-like 3, DNA helicase, RecQ-like type 2, MGC131618, DNA 3'-5' helicase BLM, RECQL2
Source: HGNC:1058
Biotype: protein coding gene
CDK2
(Homo sapiens)Gene
Name: cyclin dependent kinase 2
Synonyms: cdc2-related protein kinase, p33 protein kinase, p33(CDK2), cyclin-dependent kinase 2, cell division protein kinase 2, cell devision kinase 2, CDKN2
Source: HGNC:1771
Biotype: protein coding gene
PRKDC
(Homo sapiens)Gene
Name: protein kinase, DNA-activated, catalytic subunit
Synonyms: HYRC, DNA-PKcs, DNAPKc, XRCC7, DNA-PK catalytic subunit, DNA-dependent protein kinase catalytic subunit, IMD26, p460, p350, DNPK1, HYRC1, DNAPK, DNA-PKC, hyper-radiosensitivity of murine scid mutation, complementing 1
Source: HGNC:9413
Biotype: protein coding gene
INO80
(Saccharomyces cerevisiae)Gene
Name: INOsitol requiring
Synonyms: YGL150C
Source: SGD:S000003118
Biotype: protein coding gene
FEN1
(Homo sapiens)Gene
Name: flap structure-specific endonuclease 1
Synonyms: flap endonuclease 1, maturation factor 1, MF1, hFEN-1, FEN-1, maturation factor-1, RAD2, DNase IV
Source: HGNC:3650
Biotype: protein coding gene
Hspa1a
(Mus musculus)Gene
Name: heat shock protein 1A
Synonyms: HSP70-2, HSP70.2, HSP70-1, Hsp70-2, Hsp70.3, HSP70.1, heat shock protein, 70 kDa 3, HSP70, Hsp70-1, Hsp70-3, Hsp68, Hsp72, Hsp70a1, Hspa1, Hspa2, HSP72
Source: MGI:96244
Biotype: protein coding gene
Recql4
(Mus musculus)Gene
Name: RecQ protein-like 4
Synonyms: Not Available
Source: MGI:1931028
Biotype: protein coding gene
RAD51
(Homo sapiens)Gene
Name: RAD51 recombinase
Synonyms: recombination protein A, RAD51 homolog A, RecA-like protein, RAD51 homolog (RecA homolog, E. coli), MRMV2, RecA, E. coli, homolog of, HsRad51, HsT16930, BRCC5, BRCA1/BRCA2-containing complex, subunit 5, RAD51A, DNA repair protein RAD51 homolog 1, HRAD51, RECA, FANCR, truncated RAD51
Source: HGNC:9817
Biotype: protein coding gene
DNA2
(Saccharomyces cerevisiae)Gene
Name: DNA synthesis defective
Synonyms: YHR164C, WEB2
Source: SGD:S000001207
Biotype: protein coding gene
SET1
(Saccharomyces cerevisiae)Gene
Name: SET domain-containing
Synonyms: KMT2, YHR119W, YTX1
Source: SGD:S000001161
Biotype: protein coding gene
RAD51
(Saccharomyces cerevisiae)Gene
Name: RADiation sensitive
Synonyms: YER095W, MUT5
Source: SGD:S000000897
Biotype: protein coding gene
MRE11
(Saccharomyces cerevisiae)Gene
Name: Meiotic REcombination
Synonyms: XRS4, NGS1, YMR224C, RAD58
Source: SGD:S000004837
Biotype: protein coding gene
Apex1
(Mus musculus)Gene
Name: apurinic/apyrimidinic endonuclease 1
Synonyms: REF-1, Ref-1, APE, HAP1, Apex
Source: MGI:88042
Biotype: protein coding gene
MEC1
(Saccharomyces cerevisiae)Gene
Name: Mitosis Entry Checkpoint
Synonyms: RAD31, YBR136W, SAD3, ESR1
Source: SGD:S000000340
Biotype: protein coding gene
RAD50
(Saccharomyces cerevisiae)Gene
Name: RADiation sensitive
Synonyms: YNL250W
Source: SGD:S000005194
Biotype: protein coding gene
RAD51C
(Homo sapiens)Gene
Name: RAD51 paralog C
Synonyms: MGC104277, truncated RAD51C, BROVCA3, R51H3, FANCO, RAD51L2, yeast RAD51 homolog 3, RAD51 homolog C, isoform 1, RAD51-like protein 2, DNA repair protein RAD51 homolog 3
Source: HGNC:9820
Biotype: protein coding gene
RECQL4
(Homo sapiens)Gene
Name: RecQ like helicase 4
Synonyms: RECQ4, ATP-dependent DNA helicase Q4, DNA helicase, RecQ-like, type 4, DNA 3'-5' helicase RecQ4, DNA helicase, RecQ-like type 4, RecQ helicase-like 4, RecQ protein-like 4
Source: HGNC:9949
Biotype: protein coding gene
INO80
(Homo sapiens)Gene
Name: INO80 complex ATPase subunit
Synonyms: INOC1, INO80 complex subunit, homolog of yeast INO80, INO80 complex subunit A, DNA helicase-related protein INO80, putative DNA helicase INO80 complex homolog 1, chromatin-remodeling ATPase INO80, hINO80, INO80 homolog, DNA helicase INO80, INO80A, DNA helicase-related INO80 complex homolog 1
Source: HGNC:26956
Biotype: protein coding gene
atl-1
(Caenorhabditis elegans)Gene
Name: ATM (ataxia telangectasia mutated)-Like 1
Synonyms: Ce-atl1, T06E4.3, CELE_T06E4.3
Source: WB:WBGene00000226
Biotype: protein coding gene
GLC7
(Saccharomyces cerevisiae)Gene
Name: GLyCogen
Synonyms: PP1, DIS2, DIS2S1, CID1, YER133W
Source: SGD:S000000935
Biotype: protein coding gene
Hsp90aa1
(Mus musculus)Gene
Name: heat shock protein 90, alpha (cytosolic), class A member 1
Synonyms: Hsp86-1, AL024080, heat shock protein, AL024147, expressed sequence AL024080, Hsp89, heat shock protein, 90 kDa, Hspca, Hsp86, Hsp90, heat shock protein, 1, heat shock protein 1, alpha, hsp4, expressed sequence AL024147
Source: MGI:96250
Biotype: protein coding gene
Hsp90ab1
(Rattus norvegicus)Gene
Name: heat shock protein 90 alpha family class B member 1
Synonyms: heat shock protein 90kDa alpha family class B member 1, HSP 84, heat shock protein HSP 90-beta, heat shock protein 90 alpha (cytosolic), class B member 1, Hspcb, HSPC2, heat shock 84 kDa, MGC94263, heat shock 90kDa protein 1, beta, HSP90B, HSP90-BETA, HSP84, heat shock protein 90kDa alpha (cytosolic), class B member 1
Source: RGD:1303075
Biotype: protein coding gene
RFA1
(Saccharomyces cerevisiae)Gene
Name: Replication Factor A
Synonyms: BUF2, RPA70, FUN3, RPA1, YAR007C
Source: SGD:S000000065
Biotype: protein coding gene
Atr
(Mus musculus)Gene
Name: ataxia telangiectasia and Rad3 related
Synonyms: Not Available
Source: MGI:108028
Biotype: protein coding gene
PARP1
(Homo sapiens)Gene
Name: poly(ADP-ribose) polymerase 1
Synonyms: poly (ADP-ribose) polymerase 1, ADP-ribosyltransferase (NAD+, poly (ADP-ribose) polymerase), poly(ADP-ribose) polymerase, PARP, ARTD1, ADPRT 1, ADPRT1, PARP-1, NAD(+) ADP-ribosyltransferase 1, Poly-PARP, poly(ADP-ribosyl)transferase, pADPRT-1, DNA ADP-ribosyltransferase PARP1, poly [ADP-ribose] polymerase 1, ADP-ribosyltransferase NAD(+), PARS, poly (ADP-ribose) polymerase family, member 1, PPOL, ADP-ribosyltransferase diphtheria toxin-like 1, poly[ADP-ribose] synthase 1, ADPRT, poly(ADP-ribose) synthetase
Source: HGNC:270
Biotype: protein coding gene
RAD53
(Saccharomyces cerevisiae)Gene
Name: RADiation sensitive
Synonyms: MEC2, SPK1, LSD1, YPL153C
Source: SGD:S000006074
Biotype: protein coding gene
blm
(Danio rerio)Gene
Name: BLM RecQ like helicase
Synonyms: Not Available
Source: ZFIN:ZDB-GENE-070702-5
Biotype: protein coding gene
Atm
(Mus musculus)Gene
Name: ataxia telangiectasia mutated
Synonyms: RIKEN cDNA C030026E19 gene, AI256621, C030026E19Rik, expressed sequence AI256621
Source: MGI:107202
Biotype: protein coding gene
RAD57
(Saccharomyces cerevisiae)Gene
Name: RADiation sensitive
Synonyms: YDR004W
Source: SGD:S000002411
Biotype: protein coding gene
Rad51
(Mus musculus)Gene
Name: RAD51 recombinase
Synonyms: AV304093, expressed sequence AV304093, Rad51a, RAD51A homolog (S. cerevisiae), Reca, RGD1563603, recombination and repair of radiation damage, RAD51 homolog
Source: MGI:97890
Biotype: protein coding gene
SMARCAL1
(Homo sapiens)Gene
Name: SNF2 related chromatin remodeling annealing helicase 1
Synonyms: ATP-driven annealing helicase, HARP, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, HHARP, sucrose nonfermenting protein 2-like 1, SMARCA-like protein 1, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1, HepA-related protein
Source: HGNC:11102
Biotype: protein coding gene
TOP2
(Saccharomyces cerevisiae)Gene
Name: TOPoisomerase
Synonyms: YNL088W, TOR3, TRF3
Source: SGD:S000005032
Biotype: protein coding gene
XRCC6
(Homo sapiens)Gene
Name: X-ray repair cross complementing 6
Synonyms: KU70, Ku autoantigen, 70kDa, CTCBF, DNA repair protein XRCC6, lupus Ku autoantigen protein p70, CTC75, thyroid autoantigen 70kD (Ku antigen), G22P1, 5'-dRP lyase Ku70, X-ray repair cross-complementing protein 6, ATP-dependent DNA helicase II, 70 kDa subunit, thyroid autoantigen 70kDa (Ku antigen), X-ray repair complementing defective repair in Chinese hamster cells 6, 70 kDa subunit of Ku antigen, ATP-dependent DNA helicase 2 subunit 1, ML8, ATP-dependent DNA helicase II 70 kDa subunit, CTC box binding factor 75 kDa subunit, CTC box-binding factor 75 kDa subunit, thyroid-lupus autoantigen p70, Ku autoantigen p70 subunit, TLAA, 5'-deoxyribose-5-phosphate lyase Ku70
Source: HGNC:4055
Biotype: protein coding gene