Version: 8.0.0Date: Tue Jan 28 2025
Gene Diseases: cancer Molecular Function: damaged DNA binding
BRCA1
(Homo sapiens)Gene
Name: BRCA1 DNA repair associated
Synonyms: RNF53, early onset breast cancer 1, truncated breast and ovarian cancer susceptibility protein 1, truncated breast cancer 1, BRCC1, BRCA1, DNA repair associated, RING finger protein 53, breast and ovarian cancer susceptibility protein 1, BRCA1/BRCA2-containing complex, subunit 1, breast cancer 1, early onset, IRIS, Fanconi anemia, complementation group S, breast cancer type 1 susceptibility protein, BRCAI, PNCA4, PSCP, truncated BRCA1, BROVCA1, protein phosphatase 1, regulatory subunit 53, breast cancer 1, PPP1R53, FANCS
Source: HGNC:1100
Biotype: protein coding gene
ERCC5
(Homo sapiens)Gene
Name: ERCC excision repair 5, endonuclease
Synonyms: xeroderma pigmentosum, complementation group G, ERCC5-201, UVDR, ERCM2, xeroderma pigmentosum group G-complementing protein, XPG, COFS3, excision repair protein, excision repair cross-complementing rodent repair deficiency, complementation group 5, DNA repair protein complementing XP-G cells, excision repair cross-complementation group 5, XPG-complementing protein, DNA excision repair protein ERCC-5, XPGC, xeroderma pigmentosum complementation group G protein
Source: HGNC:3437
Biotype: protein coding gene
ERCC2
(Homo sapiens)Gene
Name: ERCC excision repair 2, TFIIH core complex helicase subunit
Synonyms: general transcription and DNA repair factor IIH helicase subunit XPD, TTD, TFIIH basal transcription factor complex 80 kDa subunit, TTD1, TFIIH basal transcription factor complex helicase subunit, COFS2, DNA 5'-3' helicase XPD, XPD, EM9, excision repair cross-complementing rodent repair deficiency, complementation group 2, xeroderma pigmentosum complementary group D, xeroderma pigmentosum group D-complementing protein, BTF2 p80, basic transcription factor 2 80 kDa subunit, trichothiodystrophy, MGC102762, MGC126218, DNA repair protein complementing XP-D cells, TFIIH basal transcription factor complex helicase XPB subunit, MGC126219, excision repair cross-complementation group 2, TFIIH basal transcription factor complex helicase XPD subunit, TFIIH subunit XPD, TFIIH, CXPD, TFIIH p80, TFIIH 80 kDa subunit, DNA excision repair protein ERCC-2
Source: HGNC:3434
Biotype: protein coding gene
Brca1
(Mus musculus)Gene
Name: breast cancer 1, early onset
Synonyms: BRCA-1
Source: MGI:104537
Biotype: protein coding gene
Brca1
(Rattus norvegicus)Gene
Name: BRCA1, DNA repair associated
Synonyms: BRCA-1, breast cancer 1, early onset, breast cancer type 1 susceptibility protein homolog, breast cancer 1, RING-type E3 ubiquitin transferase BRCA1
Source: RGD:2218
Biotype: protein coding gene
APEX1
(Homo sapiens)Gene
Name: apurinic/apyrimidinic endodeoxyribonuclease 1
Synonyms: DNA repair nuclease/redox regulator APEX1, redox factor-1, multifunctional DNA repair enzyme, deoxyribonuclease (apurinic or apyrimidinic), AP endonuclease 1, DNA-(apurinic or apyrimidinic site) lyase, APE1, APEN, DNA-(apurinic or apyrimidinic site) endonuclease, apurinic-apyrimidinic endonuclease 1, APX, apurinic/apyrimidinic exonuclease, AP lyase, AP endonuclease class I, APE, APEX nuclease (multifunctional DNA repair enzyme) 1, apurinic/apyrimidinic (abasic) endonuclease, REF1, HAP1, protein REF-1, APEX, redox factor 1
Source: HGNC:587
Biotype: protein coding gene
HMGB1
(Homo sapiens)Gene
Name: high mobility group box 1
Synonyms: HMG3, high-mobility group box 1, high-mobility group (nonhistone chromosomal) protein 1, SBP-1, high mobility group protein 1, high mobility group protein B1, Sulfoglucuronyl carbohydrate binding protein, Amphoterin, HMG-1, DKFZp686A04236, HMG1
Source: HGNC:4983
Biotype: protein coding gene
EP300
(Homo sapiens)Gene
Name: E1A binding protein p300
Synonyms: p300, p300 HAT, MKHK2, KAT3B, histone butyryltransferase p300, histone acetyltransferase p300, E1A-binding protein, 300kD, RSTS2, E1A-associated protein p300, histone crotonyltransferase p300
Source: HGNC:3373
Biotype: protein coding gene
Parp1
(Mus musculus)Gene
Name: poly (ADP-ribose) polymerase family, member 1
Synonyms: poly (ADP-ribose) polymerase, Adprt1, Parp-1, expressed sequence AI893648, Adprp, PARP, ARTD1, sPARP-1, Adprt, AI893648, RIKEN cDNA 5830444G22 gene, parp-1, 5830444G22Rik, C80510, expressed sequence C80510, ADP-ribosyltransferase (NAD+, poly (ADP-ribose) polymerase) 1
Source: MGI:1340806
Biotype: protein coding gene
WRN
(Homo sapiens)Gene
Name: WRN RecQ like helicase
Synonyms: RECQ3, RECQL3, Werner syndrome RecQ like helicase, bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, Werner syndrome, RecQ helicase-like, recQ protein-like 2, exonuclease WRN, DNA helicase, RecQ-like type 3, DKFZp686C2056, RECQL2, Werner syndrome ATP-dependent helicase
Source: HGNC:12791
Biotype: protein coding gene
Xpc
(Mus musculus)Gene
Name: xeroderma pigmentosum, complementation group C
Synonyms: Not Available
Source: MGI:103557
Biotype: protein coding gene
MSH2
(Homo sapiens)Gene
Name: mutS homolog 2
Synonyms: LCFS2, MSH-2, hMSH2, mismatch repair protein, HNPCC1, LOC124907764, DNA mismatch repair protein Msh2, FCC1, mutS protein homolog 2, LYNCH1, HNPCC, mutS homolog 2, colon cancer, nonpolyposis type 1, COCA1, MutS-like 2, MMRCS2, truncated MSH2, DNA mismatch repair protein Msh2 transcript, uncharacterized LOC124907764
Source: HGNC:7325
Biotype: protein coding gene
PARP1
(Homo sapiens)Gene
Name: poly(ADP-ribose) polymerase 1
Synonyms: poly (ADP-ribose) polymerase 1, ADP-ribosyltransferase (NAD+, poly (ADP-ribose) polymerase), poly(ADP-ribose) polymerase, PARP, ARTD1, ADPRT 1, ADPRT1, PARP-1, NAD(+) ADP-ribosyltransferase 1, Poly-PARP, poly(ADP-ribosyl)transferase, pADPRT-1, DNA ADP-ribosyltransferase PARP1, poly [ADP-ribose] polymerase 1, ADP-ribosyltransferase NAD(+), PARS, poly (ADP-ribose) polymerase family, member 1, PPOL, ADP-ribosyltransferase diphtheria toxin-like 1, poly[ADP-ribose] synthase 1, ADPRT, poly(ADP-ribose) synthetase
Source: HGNC:270
Biotype: protein coding gene
RAD3
(Saccharomyces cerevisiae)Gene
Name: RADiation sensitive
Synonyms: REM1, YER171W
Source: SGD:S000000973
Biotype: protein coding gene
Ep300
(Mus musculus)Gene
Name: E1A binding protein p300
Synonyms: p300, KAT3B
Source: MGI:1276116
Biotype: protein coding gene
OGG1
(Homo sapiens)Gene
Name: 8-oxoguanine DNA glycosylase
Synonyms: HOGG1, AP lyase, HMMH, 8-hydroxyguanine DNA glycosylase, MUTM, OGH1, DNA-apurinic or apyrimidinic site lyase, OGG1 type 1f, N-glycosylase/DNA lyase
Source: HGNC:8125
Biotype: protein coding gene
PCNA
(Homo sapiens)Gene
Name: proliferating cell nuclear antigen
Synonyms: cyclin, DNA polymerase delta auxiliary protein, MGC8367, ATLD2
Source: HGNC:8729
Biotype: protein coding gene
FEN1
(Homo sapiens)Gene
Name: flap structure-specific endonuclease 1
Synonyms: flap endonuclease 1, maturation factor 1, MF1, hFEN-1, FEN-1, maturation factor-1, RAD2, DNase IV
Source: HGNC:3650
Biotype: protein coding gene
CREBBP
(Homo sapiens)Gene
Name: CREB binding protein
Synonyms: MKHK1, CBP, CREB-binding protein, KAT3A, histone lysine acetyltransferase CREBBP, protein-lysine acetyltransferase CREBBP, RSTS, RSTS1
Source: HGNC:2348
Biotype: protein coding gene
NBN
(Homo sapiens)Gene
Name: nibrin
Synonyms: ATV, hNbs1, p95 protein of the MRE11/RAD50 complex, AT-V2, Nijmegen breakage syndrome 1 (nibrin), P95, AT-V1, FLJ10155, NBS1, nijmegen breakage syndrome protein 1, cell cycle regulatory protein p95, NBS, MGC87362
Source: HGNC:7652
Biotype: protein coding gene
TP63
(Homo sapiens)Gene
Name: tumor protein p63
Synonyms: chronic ulcerative stomatitis protein, OFC8, amplified in squamous cell carcinoma, keratinocyte transcription factor KET, p51, B(p51A), p73H, CUSP, TP53CP, EEC3, RHS, NBP, tumor protein p53-competing protein, tumor protein p53-like, tumor protein p63 deltaN isoform delta, AIS, SHFM4, transformation-related protein 63, p63, p40, B(p51B), TP73L, p73L, LMS, TP53L, p53CP, KET, tumor protein p73-like, tumor protein 63
Source: HGNC:15979
Biotype: protein coding gene
ERCC3
(Homo sapiens)Gene
Name: ERCC excision repair 3, TFIIH core complex helicase subunit
Synonyms: GTF2H, TFIIH p89, excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing), xeroderma pigmentosum, complementation group B, TTD2, XPB, xeroderma pigmentosum group B-complementing protein, general transcription and DNA repair factor IIH helicase subunit XPB, BTF2 p89, DNA repair protein complementing XP-B cells, excision repair cross-complementing rodent repair deficiency, complementation group 3, TFIIH 89 kDa subunit, RAD25, BTF2, Ssl2, general transcription and DNA repair factor IIH helicase/translocase subunit XPB, TFIIH basal transcription factor complex helicase XPB subunit, DNA 3'-5' helicase/translocase XPB, excision repair cross-complementation group 3, basic transcription factor 2 89 kDa subunit, TFIIH basal transcription factor complex 89 kDa subunit, xeroderma pigmentosum group B complementing, TFIIH, TFIIH subunit XPB, DNA excision repair protein ERCC-3, DNA repair helicase
Source: HGNC:3435
Biotype: protein coding gene
Apex1
(Mus musculus)Gene
Name: apurinic/apyrimidinic endonuclease 1
Synonyms: REF-1, Ref-1, APE, HAP1, Apex
Source: MGI:88042
Biotype: protein coding gene
POLD1
(Homo sapiens)Gene
Name: DNA polymerase delta 1, catalytic subunit
Synonyms: IMD120, polymerase (DNA) delta 1, catalytic subunit, DNA polymerase delta catalytic subunit, CRCS10, DNA-directed polymerase delta 1, polymerase (DNA directed), delta 1, catalytic subunit 125kDa, CDC2, POLD, DAN polymerase delta 1, catalytic subunit, dna polymerase delta, catalytic subunit, CDC2 homolog, MDPL, DNA polymerase subunit delta p125, 3'-5' exodeoxyribonuclease
Source: HGNC:9175
Biotype: protein coding gene
Crebbp
(Mus musculus)Gene
Name: CREB binding protein
Synonyms: CBP, RTS, expressed sequence AW558298, KAT3A, RSTS, AW558298
Source: MGI:1098280
Biotype: protein coding gene
ERCC4
(Homo sapiens)Gene
Name: ERCC excision repair 4, endonuclease catalytic subunit
Synonyms: excision-repair, complementing defective, in Chinese hamster, XFEPS, xeroderma pigmentosum, complementation group F, ERCC11, XPF, excision repair cross-complementing rodent repair deficiency, complementation group 4, excision repair cross-complementation group 4, FANCQ, xeroderma pigmentosum group F-complementing protein, RAD1, DNA repair endonuclease XPF, DNA excision repair protein ERCC-4, DNA repair protein complementing XP-F cells
Source: HGNC:3436
Biotype: protein coding gene
XRCC6
(Homo sapiens)Gene
Name: X-ray repair cross complementing 6
Synonyms: KU70, Ku autoantigen, 70kDa, CTCBF, DNA repair protein XRCC6, lupus Ku autoantigen protein p70, CTC75, thyroid autoantigen 70kD (Ku antigen), G22P1, 5'-dRP lyase Ku70, X-ray repair cross-complementing protein 6, ATP-dependent DNA helicase II, 70 kDa subunit, thyroid autoantigen 70kDa (Ku antigen), X-ray repair complementing defective repair in Chinese hamster cells 6, 70 kDa subunit of Ku antigen, ATP-dependent DNA helicase 2 subunit 1, ML8, ATP-dependent DNA helicase II 70 kDa subunit, CTC box binding factor 75 kDa subunit, CTC box-binding factor 75 kDa subunit, thyroid-lupus autoantigen p70, Ku autoantigen p70 subunit, TLAA, 5'-deoxyribose-5-phosphate lyase Ku70
Source: HGNC:4055
Biotype: protein coding gene
MSH6
(Homo sapiens)Gene
Name: mutS homolog 6
Synonyms: hMSH6, GTMBP, mutS protein homolog 6, HNPCC5, DNA mismatch repair protein Msh6, MSH-6, p160, sperm-associated protein, LYNCH5, mutS-like protein 6, MMRCS3, GTBP, G/T mismatch-binding protein, HSAP, mutS-alpha 160 kDa subunit, truncated MSH6
Source: HGNC:7329
Biotype: protein coding gene
H2AX
(Homo sapiens)Gene
Name: H2A.X variant histone
Synonyms: H2A histone family, member X, histone H2A.x, H2AFX, H2AX histone, histone H2AX, H2A histone family member X, H2A/X, H2A.X
Source: HGNC:4739
Biotype: protein coding gene
Hmgb1
(Mus musculus)Gene
Name: high mobility group box 1
Synonyms: Ac2-008, amphoterin, DEF, high mobility group protein 1, SBP-1, p30, HMG-1, Hmg1
Source: MGI:96113
Biotype: protein coding gene
Trp63
(Mus musculus)Gene
Name: transformation related protein 63
Synonyms: expressed sequence AI462811, p53-related protein 1, P73l, KET protein, Tp73l, Trp53rp1, p63, AI462811, p73L, deltaNp63, Ket, TAp63, p51/p63
Source: MGI:1330810
Biotype: protein coding gene
Pcna
(Mus musculus)Gene
Name: proliferating cell nuclear antigen
Synonyms: Pcna/cyclin, PCNAR
Source: MGI:97503
Biotype: protein coding gene
MUTYH
(Homo sapiens)Gene
Name: mutY DNA glycosylase
Synonyms: CYP2C, adenine DNA glycosylase, hMYH, MYH, A/G-specific adenine DNA glycosylase, MGC4416, mutY homolog
Source: HGNC:7527
Biotype: protein coding gene
ERCC1
(Homo sapiens)Gene
Name: ERCC excision repair 1, endonuclease non-catalytic subunit
Synonyms: excision repair cross-complementation group 1, RAD10, UV20, DNA excision repair protein ERCC-1, excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence), COFS4
Source: HGNC:3433
Biotype: protein coding gene
POT1
(Homo sapiens)Gene
Name: protection of telomeres 1
Synonyms: GLM9, PFBMFT8, POT1-like telomere end-binding protein, DKFZp586D211, CMM10, HPOT1, POT1 protection of telomeres 1 homolog, CRMCC3, protection of telomeres 1 homolog, protection of telomeres protein 1, TPDS3
Source: HGNC:17284
Biotype: protein coding gene
Pold1
(Rattus norvegicus)Gene
Name: DNA polymerase delta 1, catalytic subunit
Synonyms: polymerase (DNA) delta 1, catalytic subunit, DNA polymerase delta catalytic subunit, DAN polymerase delta 1, catalytic subunit, polymerase (DNA directed), delta 1, catalytic subunit, DNA polymerase delta, catalytic subunit, DNA-directed DNA polymerase delta 1, 3'-5' exodeoxyribonuclease
Source: RGD:621839
Biotype: protein coding gene
Msh2
(Mus musculus)Gene
Name: mutS homolog 2
Synonyms: expressed sequence AI788990, AI788990
Source: MGI:101816
Biotype: protein coding gene
YKU70
(Saccharomyces cerevisiae)Gene
Name: Yeast KU protein
Synonyms: KU70, NES24, HDF1, YMR284W
Source: SGD:S000004897
Biotype: protein coding gene
RAD10
(Saccharomyces cerevisiae)Gene
Name: RADiation sensitive
Synonyms: YML095C
Source: SGD:S000004560
Biotype: protein coding gene
Ercc1
(Mus musculus)Gene
Name: excision repair cross-complementing rodent repair deficiency, complementation group 1
Synonyms: Ercc-1, excision repair 1
Source: MGI:95412
Biotype: protein coding gene
XPC
(Homo sapiens)Gene
Name: XPC complex subunit, DNA damage recognition and repair factor
Synonyms: XPCC, xeroderma pigmentosum, complementation group C, mutant xeroderma pigmentosum group C, p125, RAD4, XP3, DNA repair protein complementing XP-C cells
Source: HGNC:12816
Biotype: protein coding gene
MSH3
(Homo sapiens)Gene
Name: mutS homolog 3
Synonyms: divergent upstream protein, MRP1, hMSH3, DNA mismatch repair protein Msh3, MGC163306, DUP, MGC163308, mismatch repair protein 1, FAP4
Source: HGNC:7326
Biotype: protein coding gene
Crebbp
(Rattus norvegicus)Gene
Name: CREB binding protein
Synonyms: CBP, RTS, CREB-binding protein, Creb binding protein (CBP), histone lysine acetyltransferase CREBBP, protein-lysine acetyltransferase CREBBP, RSTS
Source: RGD:2401
Biotype: protein coding gene
Pold1
(Mus musculus)Gene
Name: polymerase (DNA directed), delta 1, catalytic subunit
Synonyms: 125kDa
Source: MGI:97741
Biotype: protein coding gene
RAD4
(Saccharomyces cerevisiae)Gene
Name: RADiation sensitive
Synonyms: YER162C
Source: SGD:S000000964
Biotype: protein coding gene
Xrcc5
(Mus musculus)Gene
Name: X-ray repair complementing defective repair in Chinese hamster cells 5
Synonyms: Ku80, AI314015, expressed sequence AI314015, Kup80, Ku86
Source: MGI:104517
Biotype: protein coding gene
Ercc5
(Mus musculus)Gene
Name: excision repair cross-complementing rodent repair deficiency, complementation group 5
Synonyms: xeroderma pigmentosum, complementation group G, Xpg
Source: MGI:103582
Biotype: protein coding gene
Ku80
(Drosophila melanogaster)Gene
Name: Ku80
Synonyms: ku80, BG:DS09217.6, KU80, DmKu80, CG18801, Ku
Source: FB:FBgn0041627
Biotype: protein coding gene
H2ax
(Mus musculus)Gene
Name: H2A.X variant histone
Synonyms: H2A histone family, member X, gammaH2ax, RGD1566119, histone 5 protein 2ax, Hist5-2ax, H2AX histone, H2afx, AW228881, expressed sequence AW228881, H2A.X
Source: MGI:102688
Biotype: protein coding gene
Pot1a
(Mus musculus)Gene
Name: protection of telomeres 1A
Synonyms: 1500031H18Rik, expressed sequence AI851169, Pot1, AI851169, protection of telomeres 1, RIKEN cDNA 1500031H18 gene
Source: MGI:2141503
Biotype: protein coding gene