Version: 8.0.0Date: Tue Jan 28 2025
Gene Molecular Function: damaged DNA binding
BRCA1
(Homo sapiens)Gene
Name: BRCA1 DNA repair associated
Synonyms: RNF53, early onset breast cancer 1, truncated breast and ovarian cancer susceptibility protein 1, truncated breast cancer 1, BRCC1, BRCA1, DNA repair associated, RING finger protein 53, breast and ovarian cancer susceptibility protein 1, BRCA1/BRCA2-containing complex, subunit 1, breast cancer 1, early onset, IRIS, Fanconi anemia, complementation group S, breast cancer type 1 susceptibility protein, BRCAI, PNCA4, PSCP, truncated BRCA1, BROVCA1, protein phosphatase 1, regulatory subunit 53, breast cancer 1, PPP1R53, FANCS
Source: HGNC:1100
Biotype: protein coding gene
ERCC5
(Homo sapiens)Gene
Name: ERCC excision repair 5, endonuclease
Synonyms: xeroderma pigmentosum, complementation group G, ERCC5-201, UVDR, ERCM2, xeroderma pigmentosum group G-complementing protein, XPG, COFS3, excision repair protein, excision repair cross-complementing rodent repair deficiency, complementation group 5, DNA repair protein complementing XP-G cells, excision repair cross-complementation group 5, XPG-complementing protein, DNA excision repair protein ERCC-5, XPGC, xeroderma pigmentosum complementation group G protein
Source: HGNC:3437
Biotype: protein coding gene
TP53BP1
(Homo sapiens)Gene
Name: tumor protein p53 binding protein 1
Synonyms: p53-binding protein 1, FLJ41424, tumor protein p53-binding protein, 1, TDRD30, p53BP1, MGC138366, 53BP1, p202, tumor protein 53-binding protein, 1, TP53-binding protein 1, TP53, tumor suppressor p53-binding protein 1
Source: HGNC:11999
Biotype: protein coding gene
ERCC2
(Homo sapiens)Gene
Name: ERCC excision repair 2, TFIIH core complex helicase subunit
Synonyms: general transcription and DNA repair factor IIH helicase subunit XPD, TTD, TFIIH basal transcription factor complex 80 kDa subunit, TTD1, TFIIH basal transcription factor complex helicase subunit, COFS2, DNA 5'-3' helicase XPD, XPD, EM9, excision repair cross-complementing rodent repair deficiency, complementation group 2, xeroderma pigmentosum complementary group D, xeroderma pigmentosum group D-complementing protein, BTF2 p80, basic transcription factor 2 80 kDa subunit, trichothiodystrophy, MGC102762, MGC126218, DNA repair protein complementing XP-D cells, TFIIH basal transcription factor complex helicase XPB subunit, MGC126219, excision repair cross-complementation group 2, TFIIH basal transcription factor complex helicase XPD subunit, TFIIH subunit XPD, TFIIH, CXPD, TFIIH p80, TFIIH 80 kDa subunit, DNA excision repair protein ERCC-2
Source: HGNC:3434
Biotype: protein coding gene
Brca1
(Mus musculus)Gene
Name: breast cancer 1, early onset
Synonyms: BRCA-1
Source: MGI:104537
Biotype: protein coding gene
XPA
(Homo sapiens)Gene
Name: XPA, DNA damage recognition and repair factor
Synonyms: XPAC, RP11-244N9.4, xeroderma pigmentosum, complementation group A, XP1, excision repair-controlling, DNA repair protein complementing XP-A cells, xeroderma pigmentosum group A-complementing protein, mutant xeroderma pigmentosum complementation group A
Source: HGNC:12814
Biotype: protein coding gene
Brca1
(Rattus norvegicus)Gene
Name: BRCA1, DNA repair associated
Synonyms: BRCA-1, breast cancer 1, early onset, breast cancer type 1 susceptibility protein homolog, breast cancer 1, RING-type E3 ubiquitin transferase BRCA1
Source: RGD:2218
Biotype: protein coding gene
APEX1
(Homo sapiens)Gene
Name: apurinic/apyrimidinic endodeoxyribonuclease 1
Synonyms: DNA repair nuclease/redox regulator APEX1, redox factor-1, multifunctional DNA repair enzyme, deoxyribonuclease (apurinic or apyrimidinic), AP endonuclease 1, DNA-(apurinic or apyrimidinic site) lyase, APE1, APEN, DNA-(apurinic or apyrimidinic site) endonuclease, apurinic-apyrimidinic endonuclease 1, APX, apurinic/apyrimidinic exonuclease, AP lyase, AP endonuclease class I, APE, APEX nuclease (multifunctional DNA repair enzyme) 1, apurinic/apyrimidinic (abasic) endonuclease, REF1, HAP1, protein REF-1, APEX, redox factor 1
Source: HGNC:587
Biotype: protein coding gene
HMGB1
(Homo sapiens)Gene
Name: high mobility group box 1
Synonyms: HMG3, high-mobility group box 1, high-mobility group (nonhistone chromosomal) protein 1, SBP-1, high mobility group protein 1, high mobility group protein B1, Sulfoglucuronyl carbohydrate binding protein, Amphoterin, HMG-1, DKFZp686A04236, HMG1
Source: HGNC:4983
Biotype: protein coding gene
EP300
(Homo sapiens)Gene
Name: E1A binding protein p300
Synonyms: p300, p300 HAT, MKHK2, KAT3B, histone butyryltransferase p300, histone acetyltransferase p300, E1A-binding protein, 300kD, RSTS2, E1A-associated protein p300, histone crotonyltransferase p300
Source: HGNC:3373
Biotype: protein coding gene
IXR1
(Saccharomyces cerevisiae)Gene
Name: Intrastrand cross (X)-link Recognition
Synonyms: YKL032C, ORD1
Source: SGD:S000001515
Biotype: protein coding gene
Rad23b
(Mus musculus)Gene
Name: RAD23 homolog B, nucleotide excision repair protein
Synonyms: AV001138, mHR23B, RIKEN cDNA 0610007D13 gene, 0610007D13Rik, expressed sequence AV001138
Source: MGI:105128
Biotype: protein coding gene
SIRT6
(Homo sapiens)Gene
Name: sirtuin 6
Synonyms: NAD-dependent protein deacylase sirtuin-6, regulatory protein SIR2 homolog 6, sirtuin, NAD-dependent deacetylase sirtuin-6, SIR2-like protein 6, sirtuin type 6, hSIRT6, NAD-dependent protein deacetylase sirtuin-6, SIR2L6, sir2-related protein type 6
Source: HGNC:14934
Biotype: protein coding gene
Parp1
(Mus musculus)Gene
Name: poly (ADP-ribose) polymerase family, member 1
Synonyms: poly (ADP-ribose) polymerase, Adprt1, Parp-1, expressed sequence AI893648, Adprp, PARP, ARTD1, sPARP-1, Adprt, AI893648, RIKEN cDNA 5830444G22 gene, parp-1, 5830444G22Rik, C80510, expressed sequence C80510, ADP-ribosyltransferase (NAD+, poly (ADP-ribose) polymerase) 1
Source: MGI:1340806
Biotype: protein coding gene
WRN
(Homo sapiens)Gene
Name: WRN RecQ like helicase
Synonyms: RECQ3, RECQL3, Werner syndrome RecQ like helicase, bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, Werner syndrome, RecQ helicase-like, recQ protein-like 2, exonuclease WRN, DNA helicase, RecQ-like type 3, DKFZp686C2056, RECQL2, Werner syndrome ATP-dependent helicase
Source: HGNC:12791
Biotype: protein coding gene
BLM
(Homo sapiens)Gene
Name: BLM RecQ like helicase
Synonyms: MGRISCE1, Bloom syndrome RecQ like helicase, MGC131620, recQ-like DNA helicase BLM, Bloom syndrome, RecQ helicase-like, MGC126616, RECQL3, BS, RECQ2, Bloom syndrome protein, recQ protein-like 3, DNA helicase, RecQ-like type 2, MGC131618, DNA 3'-5' helicase BLM, RECQL2
Source: HGNC:1058
Biotype: protein coding gene
xpa
(Danio rerio)Gene
Name: xeroderma pigmentosum, complementation group A
Synonyms: zgc:63640
Source: ZFIN:ZDB-GENE-040426-1205
Biotype: protein coding gene
Xpc
(Mus musculus)Gene
Name: xeroderma pigmentosum, complementation group C
Synonyms: Not Available
Source: MGI:103557
Biotype: protein coding gene
MSH2
(Homo sapiens)Gene
Name: mutS homolog 2
Synonyms: LCFS2, MSH-2, hMSH2, mismatch repair protein, HNPCC1, LOC124907764, DNA mismatch repair protein Msh2, FCC1, mutS protein homolog 2, LYNCH1, HNPCC, mutS homolog 2, colon cancer, nonpolyposis type 1, COCA1, MutS-like 2, MMRCS2, truncated MSH2, DNA mismatch repair protein Msh2 transcript, uncharacterized LOC124907764
Source: HGNC:7325
Biotype: protein coding gene
RBBP8
(Homo sapiens)Gene
Name: RB binding protein 8, endonuclease
Synonyms: Seckel syndrome 2, RBBP-8, CTIP, CTBP-interacting protein, retinoblastoma-binding protein 8, retinoblastoma-interacting myosin-like, COM1, SCKL2, retinoblastoma binding protein 8, sporulation in the absence of SPO11 protein 2 homolog, JAWAD, RIM, DNA endonuclease RBBP8, SAE2, retinoblastoma-interacting protein and myosin-like, JWDS
Source: HGNC:9891
Biotype: protein coding gene
RAD18
(Homo sapiens)Gene
Name: RAD18 E3 ubiquitin protein ligase
Synonyms: RAD18 homolog, hHR18, RAD18, E3 ubiquitin protein ligase, RING-type E3 ubiquitin transferase RAD18, postreplication repair protein RAD18, E3 ubiquitin-protein ligase RAD18, RAD18, S. cerevisiae, homolog, RING finger protein 73, hRAD18, RNF73, postreplication repair protein hRAD18p
Source: HGNC:18278
Biotype: protein coding gene
RAD3
(Saccharomyces cerevisiae)Gene
Name: RADiation sensitive
Synonyms: REM1, YER171W
Source: SGD:S000000973
Biotype: protein coding gene
Ep300
(Mus musculus)Gene
Name: E1A binding protein p300
Synonyms: p300, KAT3B
Source: MGI:1276116
Biotype: protein coding gene
OGG1
(Homo sapiens)Gene
Name: 8-oxoguanine DNA glycosylase
Synonyms: HOGG1, AP lyase, HMMH, 8-hydroxyguanine DNA glycosylase, MUTM, OGH1, DNA-apurinic or apyrimidinic site lyase, OGG1 type 1f, N-glycosylase/DNA lyase
Source: HGNC:8125
Biotype: protein coding gene
PCNA
(Homo sapiens)Gene
Name: proliferating cell nuclear antigen
Synonyms: cyclin, DNA polymerase delta auxiliary protein, MGC8367, ATLD2
Source: HGNC:8729
Biotype: protein coding gene
FEN1
(Homo sapiens)Gene
Name: flap structure-specific endonuclease 1
Synonyms: flap endonuclease 1, maturation factor 1, MF1, hFEN-1, FEN-1, maturation factor-1, RAD2, DNase IV
Source: HGNC:3650
Biotype: protein coding gene
CREBBP
(Homo sapiens)Gene
Name: CREB binding protein
Synonyms: MKHK1, CBP, CREB-binding protein, KAT3A, histone lysine acetyltransferase CREBBP, protein-lysine acetyltransferase CREBBP, RSTS, RSTS1
Source: HGNC:2348
Biotype: protein coding gene
Recql4
(Mus musculus)Gene
Name: RecQ protein-like 4
Synonyms: Not Available
Source: MGI:1931028
Biotype: protein coding gene
NBN
(Homo sapiens)Gene
Name: nibrin
Synonyms: ATV, hNbs1, p95 protein of the MRE11/RAD50 complex, AT-V2, Nijmegen breakage syndrome 1 (nibrin), P95, AT-V1, FLJ10155, NBS1, nijmegen breakage syndrome protein 1, cell cycle regulatory protein p95, NBS, MGC87362
Source: HGNC:7652
Biotype: protein coding gene
TP63
(Homo sapiens)Gene
Name: tumor protein p63
Synonyms: chronic ulcerative stomatitis protein, OFC8, amplified in squamous cell carcinoma, keratinocyte transcription factor KET, p51, B(p51A), p73H, CUSP, TP53CP, EEC3, RHS, NBP, tumor protein p53-competing protein, tumor protein p53-like, tumor protein p63 deltaN isoform delta, AIS, SHFM4, transformation-related protein 63, p63, p40, B(p51B), TP73L, p73L, LMS, TP53L, p53CP, KET, tumor protein p73-like, tumor protein 63
Source: HGNC:15979
Biotype: protein coding gene
ERCC3
(Homo sapiens)Gene
Name: ERCC excision repair 3, TFIIH core complex helicase subunit
Synonyms: GTF2H, TFIIH p89, excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing), xeroderma pigmentosum, complementation group B, TTD2, XPB, xeroderma pigmentosum group B-complementing protein, general transcription and DNA repair factor IIH helicase subunit XPB, BTF2 p89, DNA repair protein complementing XP-B cells, excision repair cross-complementing rodent repair deficiency, complementation group 3, TFIIH 89 kDa subunit, RAD25, BTF2, Ssl2, general transcription and DNA repair factor IIH helicase/translocase subunit XPB, TFIIH basal transcription factor complex helicase XPB subunit, DNA 3'-5' helicase/translocase XPB, excision repair cross-complementation group 3, basic transcription factor 2 89 kDa subunit, TFIIH basal transcription factor complex 89 kDa subunit, xeroderma pigmentosum group B complementing, TFIIH, TFIIH subunit XPB, DNA excision repair protein ERCC-3, DNA repair helicase
Source: HGNC:3435
Biotype: protein coding gene
Apex1
(Mus musculus)Gene
Name: apurinic/apyrimidinic endonuclease 1
Synonyms: REF-1, Ref-1, APE, HAP1, Apex
Source: MGI:88042
Biotype: protein coding gene
UNG
(Homo sapiens)Gene
Name: uracil DNA glycosylase
Synonyms: UNG15, uracil-DNA glycosylase 2, DGU, UNG2, UNG1, DKFZp781L1143, HIGM4, HIGM5, UDG, uracil-DNA glycosylase, uracil-DNA glycosylase 1, uracil-DNA glycosylase 2
Source: HGNC:12572
Biotype: protein coding gene
POLD1
(Homo sapiens)Gene
Name: DNA polymerase delta 1, catalytic subunit
Synonyms: IMD120, polymerase (DNA) delta 1, catalytic subunit, DNA polymerase delta catalytic subunit, CRCS10, DNA-directed polymerase delta 1, polymerase (DNA directed), delta 1, catalytic subunit 125kDa, CDC2, POLD, DAN polymerase delta 1, catalytic subunit, dna polymerase delta, catalytic subunit, CDC2 homolog, MDPL, DNA polymerase subunit delta p125, 3'-5' exodeoxyribonuclease
Source: HGNC:9175
Biotype: protein coding gene
RECQL4
(Homo sapiens)Gene
Name: RecQ like helicase 4
Synonyms: RECQ4, ATP-dependent DNA helicase Q4, DNA helicase, RecQ-like, type 4, DNA 3'-5' helicase RecQ4, DNA helicase, RecQ-like type 4, RecQ helicase-like 4, RecQ protein-like 4
Source: HGNC:9949
Biotype: protein coding gene
Hmgb2
(Mus musculus)Gene
Name: high mobility group box 2
Synonyms: RGD1561694, C80539, HMG2, Hmg2, high mobility group protein 2, expressed sequence C80539, RGD1559962, RGD1564519, HMG-2
Source: MGI:96157
Biotype: protein coding gene
Crebbp
(Mus musculus)Gene
Name: CREB binding protein
Synonyms: CBP, RTS, expressed sequence AW558298, KAT3A, RSTS, AW558298
Source: MGI:1098280
Biotype: protein coding gene
ERCC4
(Homo sapiens)Gene
Name: ERCC excision repair 4, endonuclease catalytic subunit
Synonyms: excision-repair, complementing defective, in Chinese hamster, XFEPS, xeroderma pigmentosum, complementation group F, ERCC11, XPF, excision repair cross-complementing rodent repair deficiency, complementation group 4, excision repair cross-complementation group 4, FANCQ, xeroderma pigmentosum group F-complementing protein, RAD1, DNA repair endonuclease XPF, DNA excision repair protein ERCC-4, DNA repair protein complementing XP-F cells
Source: HGNC:3436
Biotype: protein coding gene
RAD14
(Saccharomyces cerevisiae)Gene
Name: RADiation sensitive
Synonyms: YMR201C
Source: SGD:S000004814
Biotype: protein coding gene
Hmgb1
(Mus musculus)Gene
Name: high mobility group box 1
Synonyms: Ac2-008, amphoterin, DEF, high mobility group protein 1, SBP-1, p30, HMG-1, Hmg1
Source: MGI:96113
Biotype: protein coding gene
PARP1
(Homo sapiens)Gene
Name: poly(ADP-ribose) polymerase 1
Synonyms: poly (ADP-ribose) polymerase 1, ADP-ribosyltransferase (NAD+, poly (ADP-ribose) polymerase), poly(ADP-ribose) polymerase, PARP, ARTD1, ADPRT 1, ADPRT1, PARP-1, NAD(+) ADP-ribosyltransferase 1, Poly-PARP, poly(ADP-ribosyl)transferase, pADPRT-1, DNA ADP-ribosyltransferase PARP1, poly [ADP-ribose] polymerase 1, ADP-ribosyltransferase NAD(+), PARS, poly (ADP-ribose) polymerase family, member 1, PPOL, ADP-ribosyltransferase diphtheria toxin-like 1, poly[ADP-ribose] synthase 1, ADPRT, poly(ADP-ribose) synthetase
Source: HGNC:270
Biotype: protein coding gene
Aptx
(Drosophila melanogaster)Gene
Name: aprataxin
Synonyms: CG5316
Source: FB:FBgn0038704
Biotype: protein coding gene
SMC5
(Drosophila melanogaster)Gene
Name: Structural maintenance of chromosomes 5
Synonyms: DmSMC5, CG7783, smc5, CG32438, SMC5, Smc5, AAF51749
Source: FB:FBgn0052438
Biotype: protein coding gene
Dclre1c
(Mus musculus)Gene
Name: DNA cross-link repair 1C
Synonyms: expressed sequence AI661365, AI661365, Art, 9930121L06Rik, Snm1l, RIKEN cDNA 9930121L06 gene, Artemis
Source: MGI:2441769
Biotype: protein coding gene
SMC6
(Drosophila melanogaster)Gene
Name: Structural maintenance of chromosomes 6
Synonyms: huc95E, Huc-95DE, jnj, HU- and caffeine-dependent 95D-E, Smc6, SMC6, CG5524, AAF56254, huc[95D-E], smc6, huc[95E], HU- or caffeine-sensitive 95E, java no jive, hydroxyurea- and (or) caffeine-sensitive 95E, huc[95DE]
Source: FB:FBgn0266282
Biotype: protein coding gene
Trp63
(Mus musculus)Gene
Name: transformation related protein 63
Synonyms: expressed sequence AI462811, p53-related protein 1, P73l, KET protein, Tp73l, Trp53rp1, p63, AI462811, p73L, deltaNp63, Ket, TAp63, p51/p63
Source: MGI:1330810
Biotype: protein coding gene
rev-1
(Caenorhabditis elegans)Gene
Name: REV1 (translesion DNA polymerase) homolog 1
Synonyms: CELE_ZK675.2, ZK675.2
Source: WB:WBGene00014066
Biotype: protein coding gene
Pcna
(Mus musculus)Gene
Name: proliferating cell nuclear antigen
Synonyms: Pcna/cyclin, PCNAR
Source: MGI:97503
Biotype: protein coding gene
XRCC6
(Homo sapiens)Gene
Name: X-ray repair cross complementing 6
Synonyms: KU70, Ku autoantigen, 70kDa, CTCBF, DNA repair protein XRCC6, lupus Ku autoantigen protein p70, CTC75, thyroid autoantigen 70kD (Ku antigen), G22P1, 5'-dRP lyase Ku70, X-ray repair cross-complementing protein 6, ATP-dependent DNA helicase II, 70 kDa subunit, thyroid autoantigen 70kDa (Ku antigen), X-ray repair complementing defective repair in Chinese hamster cells 6, 70 kDa subunit of Ku antigen, ATP-dependent DNA helicase 2 subunit 1, ML8, ATP-dependent DNA helicase II 70 kDa subunit, CTC box binding factor 75 kDa subunit, CTC box-binding factor 75 kDa subunit, thyroid-lupus autoantigen p70, Ku autoantigen p70 subunit, TLAA, 5'-deoxyribose-5-phosphate lyase Ku70
Source: HGNC:4055
Biotype: protein coding gene
RFA1
(Saccharomyces cerevisiae)Gene
Name: Replication Factor A
Synonyms: BUF2, RPA70, FUN3, RPA1, YAR007C
Source: SGD:S000000065
Biotype: protein coding gene