Version: 8.0.0
Date: Tue Jan 28 2025
2,941 results for pfkfb3

PFKFB3

(Homo sapiens)
Gene
Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Synonyms: 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase, inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, iPFK-2, 6-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase, IPFK2, 6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme, 6PF-2-K/Fru-2,6-P2ase 3, PFK/FBPase 3, fructose-6-phosphate,2-kinase/fructose-2, 6-bisphosphatase, FLJ37326, renal carcinoma antigen NY-REN-56, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3, PFK2
Source: HGNC:8874
Biotype: protein coding gene
Symbol: PFKFB3 (Hsa)
Symbol: PFKFB3
Strict Orthology Symbols: pfkfb3

Pfkfb3

(Mus musculus)
Gene
Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Synonyms: RIKEN cDNA E330010H22 gene, E330010H22Rik, uPFK-2
Source: MGI:2181202
Biotype: protein coding gene
Symbol: Pfkfb3 (Mmu)
Symbol: Pfkfb3
Automated Gene Synopsis: Orthologous to human PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3).
Strict Orthology Symbols: pfkfb3
Alleles: Pfkfb3 (Mmu)...Pfkfb3 (Mmu)...Pfkfb3 (Mmu)...Pfkfb3 (Mmu)...Pfkfb3 (Mmu)

pfkfb3

(Danio rerio)
Gene
Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Synonyms: zgc:73257
Source: ZFIN:ZDB-GENE-040426-2724
Biotype: protein coding gene
Symbol: pfkfb3 (Dre)
Symbol: pfkfb3
Automated Gene Synopsis: Orthologous to human PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3).
Strict Orthology Symbols: pfkfb3

Pfkfb3

(Rattus norvegicus)
Gene
Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Synonyms: PFK/FBPase 3, 6PF-2-K/Fru-2,6-P2ase 3, 6PF-2-K/Fru-2,6-P2ASE brain-type isozyme, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3, RB2K
Source: RGD:619776
Biotype: protein coding gene
Symbol: Pfkfb3 (Rno)
Symbol: Pfkfb3
Gene Synopsis: Orthologous to human PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3); PARTICIPATES IN
Automated Gene Synopsis: Orthologous to human PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3).
Strict Orthology Symbols: pfkfb3

pfkfb3

(Xenopus tropicalis)
Gene
Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Synonyms: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3, pfkfb3
Source: Xenbase:XB-GENE-963652
Biotype: gene
Symbol: pfkfb3
Symbol: pfkfb3 (Xtr)
Automated Gene Synopsis: Orthologous to human PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3).
Synonyms: pfkfb3...pfkfb3...pfkfb3
Strict Orthology Symbols: pfkfb3

PFKFB3-AS1

(Homo sapiens)
Gene
Name: PFKFB3 antisense RNA 1
Synonyms: LOC124902371, AL157395.1, uncharacterized LOC124902371
Source: HGNC:58068
Biotype: ncRNA gene
Symbol: PFKFB3-AS1 (Hsa)
Symbol: PFKFB3-AS1

pfkfb3.S

(Xenopus laevis)
Gene
Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Synonyms: pfkfb3.S, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Source: Xenbase:XB-GENE-6078189
Biotype: gene
Symbol: pfkfb3.S (Xla)
Automated Gene Synopsis: Orthologous to human PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3).
Strict Orthology Symbols: pfkfb3
Symbol: pfkfb3.S

pfkfb3.L

(Xenopus laevis)
Gene
Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Synonyms: pfkfb3.L, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Source: Xenbase:XB-GENE-17340406
Biotype: gene
Symbol: pfkfb3.L (Xla)
Automated Gene Synopsis: Orthologous to human PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3).
Strict Orthology Symbols: pfkfb3
Symbol: pfkfb3.L

Pfkfb3tm1.1Pec

(Mus musculus)
Allele/Variant
Source: MGI:6470752
Genes: Pfkfb3 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Pfkfb3 (Mmu)
Genes: Pfkfb3 (Mmu)
Symbol: Pfkfb3tm1.1Pec

Pfkfb3em1Nju

(Mus musculus)
Allele/Variant
Source: MGI:6723804
Genes: Pfkfb3 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Pfkfb3 (Mmu)
Genes: Pfkfb3 (Mmu)
Symbol: Pfkfb3em1Nju

Pfkfb3tm1b(EUCOMM)Wtsi

(Mus musculus)
Allele/Variant
Source: MGI:5692802
Genes: Pfkfb3 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Pfkfb3 (Mmu)
Genes: Pfkfb3 (Mmu)
Symbol: Pfkfb3tm1b(EUCOMM)Wtsi

Pfkfb3em2Gpt

(Mus musculus)
Allele/Variant
Source: MGI:7304123
Genes: Pfkfb3 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Pfkfb3 (Mmu)
Genes: Pfkfb3 (Mmu)
Symbol: Pfkfb3em2Gpt

Pfkfb3tm1Jche

(Mus musculus)
Allele/Variant
Source: MGI:3576782
Genes: Pfkfb3 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Pfkfb3 (Mmu)
Genes: Pfkfb3 (Mmu)
Symbol: Pfkfb3tm1Jche

Pfkfb3tm1c(EUCOMM)Wtsi

(Mus musculus)
Allele/Variant
Source: MGI:7444932
Genes: Pfkfb3 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Pfkfb3 (Mmu)
Genes: Pfkfb3 (Mmu)
Symbol: Pfkfb3tm1c(EUCOMM)Wtsi

Pfkfb3em1Cya

(Mus musculus)
Allele/Variant
Source: MGI:7585712
Genes: Pfkfb3 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Pfkfb3 (Mmu)
Genes: Pfkfb3 (Mmu)
Symbol: Pfkfb3em1Cya

Pfkfb3tm1Xen

(Mus musculus)
Allele/Variant
Source: MGI:7580483
Genes: Pfkfb3 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Pfkfb3 (Mmu)
Genes: Pfkfb3 (Mmu)
Symbol: Pfkfb3tm1Xen

Pfkfb3tm1a(EUCOMM)Wtsi

(Mus musculus)
Allele/Variant
Source: MGI:4441922
Genes: Pfkfb3 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Pfkfb3 (Mmu)
Genes: Pfkfb3 (Mmu)
Symbol: Pfkfb3tm1a(EUCOMM)Wtsi

Pfkfb3tm1Pec

(Mus musculus)
Allele/Variant
Source: MGI:5825519
Genes: Pfkfb3 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Pfkfb3 (Mmu)
Genes: Pfkfb3 (Mmu)
Symbol: Pfkfb3tm1Pec

Pfkfb3em2Cya

(Mus musculus)
Allele/Variant
Source: MGI:7585713
Genes: Pfkfb3 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Pfkfb3 (Mmu)
Genes: Pfkfb3 (Mmu)
Symbol: Pfkfb3em2Cya

Pfkfb3em1Gpt

(Mus musculus)
Allele/Variant
Source: MGI:7304122
Genes: Pfkfb3 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Pfkfb3 (Mmu)
Genes: Pfkfb3 (Mmu)
Symbol: Pfkfb3em1Gpt

Pfkfb3tm1Jche/Pfkfb3tm1Jche [background:] B6.129-Pfkfb3tm1Jche

(Mus musculus)
Model
Id: MGI:3577467
Synonyms: Not Available
Symbol: Pfkfb3/Pfkfb3 [background:] B6.129-Pfkfb3 (Mmu)
Genes: Pfkfb3 (Mmu)
Alleles: Pfkfb3 (Mmu)
Name: Pfkfb3/Pfkfb3 [background:] B6.129-Pfkfb3

PFKFB3 inhibits fructose metabolism in pulmonary microvascular endothelial cells

(Rattus norvegicus)
HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by RGD
ID: GEO:GSE230660
Tags: unclassified
Summary: Our findings indicate that PFKFB3 is a molecular switch that controls glucose versus fructose utilization in glycolysis and help to better understand lung endothelial cell metabolism during respiratory failure.
Symbol: PFKFB3 inhibits fructose metabolism in pulmonary microvascular endothelial cells
Name: PFKFB3 inhibits fructose metabolism in pulmonary microvascular endothelial cells

Pfkfb3tm1.1Pec/Pfkfb3tm1.1Pec Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/0 [background:] involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCrl * CBA

(Mus musculus)
Model
Id: MGI:6470897
Synonyms: Not Available
Symbol: Pfkfb3/Pfkfb3 Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/0 [background:] involves: 129S6/SvEvTac
Genes: Pfkfb3 (Mmu)
Alleles: Pfkfb3 (Mmu)
Name: Pfkfb3/Pfkfb3 Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/0 [background:] involves: 129S6/SvEvTac

Pfkfb3tm1b(EUCOMM)Wtsi/Pfkfb3+ [background:] C57BL/6N-Pfkfb3tm1b(EUCOMM)Wtsi/Ieg

(Mus musculus)
Model
Id: MGI:6263145
Synonyms: Not Available
Symbol: Pfkfb3/Pfkfb3<+> [background:] C57BL/6N-Pfkfb3/Ieg (Mmu)
Genes: Pfkfb3 (Mmu)
Alleles: Pfkfb3 (Mmu)
Name: Pfkfb3/Pfkfb3<+> [background:] C57BL/6N-Pfkfb3/Ieg

pfkb-1.1

(Caenorhabditis elegans)
Gene
Name: 6-PhosphoFructo-2-Kinase/ fructose-2,6-Bisphosphatase (EC: 3.1.3.46) homolog 1.1
Synonyms: Y110A7A.6, CELE_Y110A7A.6
Source: WB:WBGene00022456
Biotype: protein coding gene
Automated Gene Synopsis: /fructose-2,6-biphosphatase 1); PFKFB2 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2); and PFKFB3
Strict Orthology Symbols: pfkfb3

pfkb-1.2

(Caenorhabditis elegans)
Gene
Name: 6-PhosphoFructo-2-Kinase/ fructose-2,6-Bisphosphatase (EC: 3.1.3.46) homolog 1.2
Synonyms: CELE_K02B2.1, K02B2.1
Source: WB:WBGene00019295
Biotype: protein coding gene
Automated Gene Synopsis: /fructose-2,6-biphosphatase 1); PFKFB2 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2); and PFKFB3
Strict Orthology Symbols: pfkfb3

FBP26

(Saccharomyces cerevisiae)
Gene
Name: Fructose BisPhosphatase
Synonyms: YJL155C
Source: SGD:S000003691
Biotype: protein coding gene
Automated Gene Synopsis: /fructose-2,6-biphosphatase 1); PFKFB2 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2); and PFKFB3
Strict Orthology Symbols: pfkfb3

Pfrx

(Drosophila melanogaster)
Gene
Name: 6-phosphofructo-2-kinase
Synonyms: fructose 2,6 bisphosphatase, CG3400, fi-phosphofructo-2-kinase, Pfk2, PFK2, pfk2, phosphofructokinase
Source: FB:FBgn0027621
Biotype: protein coding gene
Strict Orthology Symbols: pfkfb3

extrinsic cardiomyopathy

Disease
Source: DOID:3978
Definition: A cardiomyopathy that is characterized by the pathology occurring outside of the myocardium.
Genes: Pfkfb3 (Rno)...pfkfb3 (Dre)...Pfkfb3 (Mmu)...pfkfb3 (Xtr)...PFKFB3 (Hsa)

6-phosphofructo-2-kinase activity

Gene Ontology
Source: GO:0003873
Synonyms:
  • 6-phosphofructo-2-kinase (phosphorylating)
  • 6-phosphofructose 2-kinase activity
Branch: molecular function
Genes: Pfkfb3 (Mmu)...Pfkfb3 (Rno)...pfkfb3 (Dre)...PFKFB3 (Hsa)

fructose-2,6-bisphosphate 2-phosphatase activity

Gene Ontology
Source: GO:0004331
Synonyms:
  • D-fructose-2,6-bisphosphate 2-phosphohydrolase activity
  • beta-D-fructose-2,6-bisphosphate 2-phosphohydrolase activity
Branch: molecular function
Genes: Pfkfb3 (Mmu)...Pfkfb3 (Rno)...pfkfb3 (Dre)...PFKFB3 (Hsa)

Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ Pfkfb3tm1Pec/Pfkfb3tm1Pec Tg(Cdh5-cre/ERT2)1Rha/0 [background:] involves: 129S1/Sv * 129X1/SvJ

(Mus musculus)
Model
Id: MGI:5825525
Synonyms: Not Available
Genes: Pfkfb3 (Mmu)
Alleles: Pfkfb3 (Mmu)
Name: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Pfkfb3/Pfkfb3 Tg(Cdh5-cre
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Pfkfb3/Pfkfb3 Tg(Cdh5-cre

fructose 2,6-bisphosphate metabolic process

Gene Ontology
Source: GO:0006003
Synonyms:
  • fructose 2,6-bisphosphate metabolism
Branch: biological process
Genes: Pfkfb3 (Mmu)...Pfkfb3 (Rno)...pfkfb3 (Dre)...PFKFB3 (Hsa)

Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ Pfkfb3tm1Pec/Pfkfb3tm1Pec Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/0 [background:] involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

(Mus musculus)
Model
Id: MGI:5825529
Synonyms: Not Available
Genes: Pfkfb3 (Mmu)
Alleles: Pfkfb3 (Mmu)
Name: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Pfkfb3/Pfkfb3 Tg(Pdgfb-icre
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Pfkfb3/Pfkfb3 Tg(Pdgfb-icre

fructose metabolic process

Gene Ontology
Source: GO:0006000
Synonyms:
  • fructose metabolism
Branch: biological process
Genes: PFKFB3 (Hsa)...Pfkfb3 (Rno)...pfkfb3 (Dre)

motor behavior

Gene Ontology
Source: GO:0061744
Synonyms: Not Available
Branch: biological process
Genes: PFKFB3 (Hsa)...Pfkfb3 (Mmu)...Pfkfb3 (Rno)

glial cell differentiation

Gene Ontology
Source: GO:0010001
Synonyms:
  • glia cell differentiation
  • neuroglia differentiation
Branch: biological process
Genes: PFKFB3 (Hsa)...Pfkfb3 (Mmu)...Pfkfb3 (Rno)

Tg(Myh6-Pfkfb3)7Pne/0 [background:] FVB-Tg(Myh6-Pfkfb3)7Pne

(Mus musculus)
Model
Id: MGI:3640608
Synonyms: Not Available
Name: Tg(Myh6-Pfkfb3)7Pne/0 [background:] FVB-Tg(Myh6-Pfkfb3)7Pne

carbohydrate phosphorylation

Gene Ontology
Source: GO:0046835
Synonyms: Not Available
Branch: biological process
Genes: PFKFB3 (Hsa)...Pfkfb3 (Rno)

Tg(Myh6-Pfkfb3)7Pne

(Mus musculus)
Allele/Variant
Source: MGI:3640602
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: extrinsic cardiomyopathy
Variant Name: Not Available
Symbol: Tg(Myh6-Pfkfb3)7Pne
Construct Expressed Component: Pfkfb3 (Mmu)

regulation of glycolytic process

Gene Ontology
Source: GO:0006110
Synonyms:
  • regulation of glycolysis involved in cellular glucose homeostasis
Branch: biological process
Genes: Pfkfb3 (Rno)

glycolytic process

Gene Ontology
Source: GO:0006096
Synonyms:
  • Embden-Meyerhof pathway
  • Embden-Meyerhof-Parnas pathway
Branch: biological process
Genes: Pfkfb3 (Rno)...PFKFB3 (Hsa)...Pfkfb3 (Mmu)

catalytic activity

Gene Ontology
Source: GO:0003824
Synonyms:
  • enzyme activity
Branch: molecular function
Genes: pfkfb3 (Dre)...PFKFB3 (Hsa)

apoptotic process

Gene Ontology
Source: GO:0006915
Synonyms:
  • activation of apoptosis
  • apoptosis
Branch: biological process
Genes: Pfkfb3 (Mmu)...PFKFB3 (Hsa)...Pfkfb3 (Rno)

kinase activity

Gene Ontology
Source: GO:0016301
Synonyms:
  • phosphokinase activity
Branch: molecular function
Genes: pfkfb3 (Dre)...PFKFB3 (Hsa)

phosphorylation

Gene Ontology
Source: GO:0016310
Synonyms: Not Available
Branch: biological process
Genes: pfkfb3 (Dre)

ATP binding

Gene Ontology
Source: GO:0005524
Synonyms:
  • Mg-ATP binding
  • MgATP binding
Branch: molecular function
Genes: pfkfb3 (Dre)...PFKFB3 (Hsa)...Pfkfb3 (Rno)

transferase activity

Gene Ontology
Source: GO:0016740
Synonyms: Not Available
Branch: molecular function
Genes: pfkfb3 (Dre)

nucleoplasm

Gene Ontology
Source: GO:0005654
Synonyms: Not Available
Branch: cellular component
Genes: Pfkfb3 (Mmu)...PFKFB3 (Hsa)...Pfkfb3 (Rno)

sa11437

(Danio rerio)
Allele/Variant
Source: ZFIN:ZDB-ALT-130411-1272
Genes: pfkfb3 (Dre)
Synonyms: Not Available
Variant Type: point_mutation
Molecular Consequence: stop_gained
Diseases: Not Available
Variant Name: Not Available
Genes: pfkfb3 (Dre)