7,613 results for smarca4

Smarca4

(Rattus norvegicus)
Gene
Name: SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4
Synonyms: brg-1, protein brahma homolog 1, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4, ATP-dependent helicase SMARCA4, BRG1-associated factor 190A, BAF190A, SNF2-beta, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4, transcription activator BRG1
Source: RGD:621728
Biotype: protein coding gene
Symbol: Smarca4 (Rno)
Symbol: Smarca4
Gene Synopsis: Orthologous to human SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin
Automated Gene Synopsis: Orthologous to human SMARCA4 (SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4).
Synonyms: ATP-dependent helicase SMARCA4
Strict Orthology Symbols: smarca4

SMARCA4

(Homo sapiens)
Gene
Name: SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4
Synonyms: OTSC12, SNF2-like 4, BRG1, homeotic gene regulator, MRD16, BRM/SWI2-related gene 1, global transcription activator homologous sequence, SWI2, nuclear protein GRB1, SNF2-beta, FLJ39786, BAF190, BRG1-associated factor 190A, ATP-dependent helicase SMARCA4, BAF190A, sucrose nonfermenting-like 4, SNF2, SNF2L4, RTPS2, brahma protein-like 1, mitotic growth and transcription activator, transcription activator BRG1, CSS4, SNF2LB, protein brahma homolog 1, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4, protein BRG-1, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4, hSNF2b
Source: HGNC:11100
Biotype: protein coding gene
Symbol: SMARCA4 (Hsa)
Symbol: SMARCA4
Synonyms: ATP-dependent helicase SMARCA4
Strict Orthology Symbols: smarca4

Smarca4

(Mus musculus)
Gene
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Synonyms: brahma related gene 1, brg-1, Brg1, b2b508.1Clo, b2b692Clo, SW1/SNF, Mutant line 692, Mutant line 508, subline 1, SNF2beta
Source: MGI:88192
Biotype: protein coding gene
Symbol: Smarca4 (Mmu)
Symbol: Smarca4
Automated Gene Synopsis: Orthologous to human SMARCA4 (SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4).
Strict Orthology Symbols: smarca4
Alleles: Smarca4 (Mmu)...Smarca4 (Mmu)...Smarca4 (Mmu)...Smarca4 (Mmu)...Smarca4 (Mmu)

smarca4

(Xenopus tropicalis)
Gene
Name: SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4
Synonyms: rtps2, baf190, smarca4, snf2, snf2b, snf2-beta, snf2l4, SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4, BRG1, snf2lb, swi2, X-brg1
Source: Xenbase:XB-GENE-483983
Biotype: gene
Symbol: smarca4 (Xtr)
Symbol: smarca4
Automated Gene Synopsis: Orthologous to human SMARCA4 (SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4).
Synonyms: smarca4...smarca4...smarca4
Strict Orthology Symbols: smarca4.S...Smarca4...smarca4.L...smarca4a...SMARCA4

smarca4a

(Danio rerio)
Gene
Name: SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4a
Synonyms: smarca2, smarca4, wu:fb51a08, yng, brg1, young, brahma-related gene 1
Source: ZFIN:ZDB-GENE-030605-1
Biotype: protein coding gene
Symbol: smarca4a (Dre)
Automated Gene Synopsis: Orthologous to human SMARCA4 (SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4).
Synonyms: smarca4...smarca4...smarca4
Strict Orthology Symbols: smarca4
Symbol: smarca4a

smarca4.S

(Xenopus laevis)
Gene
Name: SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4
Synonyms: baf190, rtps2, snf2, smarca4.S, snf2-beta, snf2b, snf2l4, SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4, BRG1, snf2lb, swi2, X-brg1
Source: Xenbase:XB-GENE-865035
Biotype: gene
Symbol: smarca4.S (Xla)
Automated Gene Synopsis: Orthologous to human SMARCA4 (SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4).
Strict Orthology Symbols: smarca4
Symbol: smarca4.S

smarca4.L

(Xenopus laevis)
Gene
Name: SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4
Synonyms: baf190, rtps2, snf2, snf2-beta, snf2b, SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4, BRG1, snf2l4, snf2lb, smarca4.L, swi2, X-brg1
Source: Xenbase:XB-GENE-17342693
Biotype: gene
Symbol: smarca4.L (Xla)
Automated Gene Synopsis: Orthologous to human SMARCA4 (SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4).
Strict Orthology Symbols: smarca4
Symbol: smarca4.L

smarca4b

(Danio rerio)
Gene
Name: SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4b
Synonyms: zmp:0000001041
Source: ZFIN:ZDB-GENE-140106-1
Biotype: protein coding gene
Symbol: smarca4b (Dre)
Symbol: smarca4b

Smarca4tm1Tich

(Mus musculus)
Allele/Variant
Source: MGI:3830390
Genes: Smarca4 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Smarca4 (Mmu)
Genes: Smarca4 (Mmu)
Symbol: Smarca4tm1Tich

Smarca4mos6

(Mus musculus)
Allele/Variant
Source: MGI:5898019
Genes: Smarca4 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Smarca4 (Mmu)
Genes: Smarca4 (Mmu)
Symbol: Smarca4mos6

Smarca4enu1

(Mus musculus)
Allele/Variant
Source: MGI:3611933
Genes: Smarca4 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Smarca4 (Mmu)
Genes: Smarca4 (Mmu)
Symbol: Smarca4enu1

Smarca4tm1.2Pcn

(Mus musculus)
Allele/Variant
Source: MGI:3605892
Genes: Smarca4 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Smarca4 (Mmu)
Genes: Smarca4 (Mmu)
Symbol: Smarca4tm1.2Pcn

Smarca4em1Cya

(Mus musculus)
Allele/Variant
Source: MGI:7586699
Genes: Smarca4 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Smarca4 (Mmu)
Genes: Smarca4 (Mmu)
Symbol: Smarca4em1Cya

Smarca4MommeD39

(Mus musculus)
Allele/Variant
Source: MGI:5515391
Genes: Smarca4 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Smarca4 (Mmu)
Genes: Smarca4 (Mmu)
Symbol: Smarca4MommeD39

Smarca4tm1.1Grc

(Mus musculus)
Allele/Variant
Source: MGI:5645479
Genes: Smarca4 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Smarca4 (Mmu)
Genes: Smarca4 (Mmu)
Symbol: Smarca4tm1.1Grc

Smarca4em1Mgre

(Mus musculus)
Allele/Variant
Source: MGI:7713214
Genes: Smarca4 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Smarca4 (Mmu)
Genes: Smarca4 (Mmu)
Symbol: Smarca4em1Mgre

Smarca4em1Jgwu

(Mus musculus)
Allele/Variant
Source: MGI:6886074
Genes: Smarca4 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Smarca4 (Mmu)
Genes: Smarca4 (Mmu)
Symbol: Smarca4em1Jgwu

Smarca4tm1Mag

(Mus musculus)
Allele/Variant
Source: MGI:2386105
Genes: Smarca4 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: breast cancer
Variant Name: Not Available
Symbol: Smarca4 (Mmu)
Genes: Smarca4 (Mmu)
Symbol: Smarca4tm1Mag

Smarca4em1Gpt

(Mus musculus)
Allele/Variant
Source: MGI:7306504
Genes: Smarca4 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Smarca4 (Mmu)
Genes: Smarca4 (Mmu)
Symbol: Smarca4em1Gpt

Smarca4em2Jgwu

(Mus musculus)
Allele/Variant
Source: MGI:6886075
Genes: Smarca4 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Smarca4 (Mmu)
Genes: Smarca4 (Mmu)
Symbol: Smarca4em2Jgwu

Smarca4tm1.1Axvi

(Mus musculus)
Allele/Variant
Source: MGI:5578505
Genes: Smarca4 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Smarca4 (Mmu)
Genes: Smarca4 (Mmu)
Symbol: Smarca4tm1.1Axvi

Smarca4tm1Smoc

(Mus musculus)
Allele/Variant
Source: MGI:7292472
Genes: Smarca4 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Smarca4 (Mmu)
Genes: Smarca4 (Mmu)
Symbol: Smarca4tm1Smoc

Smarca4tm1.1Pcn

(Mus musculus)
Allele/Variant
Source: MGI:5009421
Genes: Smarca4 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Smarca4 (Mmu)
Genes: Smarca4 (Mmu)
Symbol: Smarca4tm1.1Pcn

Smarca4tm1Ger

(Mus musculus)
Allele/Variant
Source: MGI:7564572
Genes: Smarca4 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Smarca4 (Mmu)
Genes: Smarca4 (Mmu)
Symbol: Smarca4tm1Ger

Id: MGI:5009693
Synonyms: Not Available
Symbol: Smarca4/Smarca4<+> [background:] involves: 129S2/SvPas * C57BL/6 * DBA/2 (Mmu)
Genes: Smarca4 (Mmu)
Alleles: Smarca4 (Mmu)
Name: Smarca4/Smarca4<+> [background:] involves: 129S2/SvPas * C57BL/6 * DBA/2

Id: MGI:5699724
Synonyms: Not Available
Symbol: Smarca4/Smarca4 Nfatc1/Nfatc1<+> Gt(ROSA)26Sor
Genes: Smarca4 (Mmu)
Alleles: Smarca4 (Mmu)
Name: Smarca4/Smarca4 Nfatc1/Nfatc1<+> Gt(ROSA)26Sor

smarca4aa8/a8 (AB)

(Danio rerio)
Model
Id: ZFIN:ZDB-FISH-150901-3367
Synonyms: Not Available
Symbol: smarca4a (AB) (Dre)
Genes: smarca4a (Dre)

Id: MGI:5645482
Synonyms: Not Available
Symbol: Smarca4/Smarca4 [background:] involves: 129 * C57BL/6 (Mmu)
Genes: Smarca4 (Mmu)
Alleles: Smarca4 (Mmu)
Name: Smarca4/Smarca4 [background:] involves: 129 * C57BL/6

Id: MGI:6241341
Synonyms: Not Available
Symbol: Smarca4/Smarca4 [background:] involves: BALB/cJ * C57BL/6J (Mmu)
Genes: Smarca4 (Mmu)
Alleles: Smarca4 (Mmu)
Name: Smarca4/Smarca4 [background:] involves: BALB/cJ * C57BL/6J

Id: MGI:4819610
Synonyms: Not Available
Symbol: Smarca4/Smarca4 [background:] involves: 129S/Sv * CD-1 (Mmu)
Genes: Smarca4 (Mmu)
Alleles: Smarca4 (Mmu)
Name: Smarca4/Smarca4 [background:] involves: 129S/Sv * CD-1

Id: ZFIN:ZDB-FISH-230712-4
Synonyms: Not Available
Symbol: smarca4a; zf289Tg (Dre)
Genes: smarca4a (Dre)

Id: MGI:2677147
Synonyms: Not Available
Symbol: Smarca4/Smarca4 Tg(Lck-cre)1Cwi/?
Genes: Smarca4 (Mmu)
Alleles: Smarca4 (Mmu)
Name: Smarca4/Smarca4 Tg(Lck-cre)1Cwi/?

Id: MGI:6241342
Synonyms: Not Available
Symbol: Smarca4/Smarca4<+> Sox10/Sox10<+> [background:] involves: 129S1/Sv * 129X1/SvJ * BALB/
Genes: Smarca4 (Mmu)
Alleles: Smarca4 (Mmu)
Name: Smarca4/Smarca4<+> Sox10/Sox10<+> [background:] involves: 129S1/Sv * 129X1/SvJ * BALB/

Id: MGI:5763438
Synonyms: Not Available
Symbol: Smarca4/Smarca4<+> [background:] involves: 129S/Sv * C57BL/6J * CD-1 (Mmu)
Genes: Smarca4 (Mmu)
Alleles: Smarca4 (Mmu)
Name: Smarca4/Smarca4<+> [background:] involves: 129S/Sv * C57BL/6J * CD-1

Id: ZFIN:ZDB-FISH-230712-3
Synonyms: Not Available
Symbol: smarca4a; is5Tg; zf289Tg (Dre)
Genes: smarca4a (Dre)

Id: MGI:5316795
Synonyms: Not Available
Symbol: Smarca4/Smarca4 [background:] C57BL/6J-Smarca4 (Mmu)
Genes: Smarca4 (Mmu)
Alleles: Smarca4 (Mmu)
Name: Smarca4/Smarca4 [background:] C57BL/6J-Smarca4

Id: MGI:3606860
Synonyms: Not Available
Symbol: Smarca4/Smarca4 Tg(KRT14-cre/ERT2)1Ipc/?
Genes: Smarca4 (Mmu)
Alleles: Smarca4 (Mmu)
Name: Smarca4/Smarca4 Tg(KRT14-cre/ERT2)1Ipc/? [background:] involves: 129S2/SvPas

Id: MGI:5009694
Synonyms: Not Available
Symbol: Smarca4/Smarca4 Tg(Myh11-cre,-EGFP)2Mik/0 [background:] involves: 129S2/SvPas *
Genes: Smarca4 (Mmu)
Alleles: Smarca4 (Mmu)
Name: Smarca4/Smarca4 Tg(Myh11-cre,-EGFP)2Mik/0 [background:] involves: 129S2/SvPas *

Id: MGI:3830516
Synonyms: Not Available
Symbol: Smarca4/Smarca4<+> Tg(Lck-cre)1Cwi/0 [background:] involves: 129 (Mmu)
Genes: Smarca4 (Mmu)
Alleles: Smarca4 (Mmu)
Name: Smarca4/Smarca4<+> Tg(Lck-cre)1Cwi/0 [background:] involves: 129

smarca4aa8/a8

(Danio rerio)
Model
Id: ZFIN:ZDB-FISH-150901-22165
Synonyms: Not Available
Symbol: smarca4a (Dre)
Genes: smarca4a (Dre)

Model
Id: ZFIN:ZDB-FISH-150901-22142
Synonyms: Not Available
Symbol: smarca4a (AB) (Dre)
Genes: smarca4a (Dre)

High-Throughput (HTP) Dataset Index metadata provided by MGI
ID: ArrayExpress:GSE241018
Tags: WT vs. mutant, genotype
Summary: Almost all medulloblastomas (MB) of the Wingless/Int-1 (WNT) type are characterized by hotspot mutations in CTNNB1, and mouse models have convincingly demonstrated the tumor-initiating role of these mutations. Additional alterations in SMARCA4 are detected in around 20% of WNT MB, but their functional role is mostly unknown. We therefore amended previously described Blbp cre::Ctnnb1(ex3)fl/wt mice by the introduction of a floxed Smarca4 allele. Unexpectedly, mutated -catenin on its own induced severe developmental phenotypes in Blbp cre::Ctnnb1(ex3)fl/wt mice in our hands, including a thinned cerebral cortex, hydrocephalus, missing cerebellar layering, and non-proliferative cell accumulations in the brain stem and cerebellum. An additional loss of SMARCA4 even resulted in prenatal death for most mice. Respective Blbp cre::Ctnnb1(ex3)fl/wt::Smarca4fl/fl mutants developed large proliferative lesions in the cerebellum evolving from E13.5 to E16.5. Histological and molecular analysis of these lesions by DNA methylation profiling and single-cell RNA sequencing suggested an origin in early undifferentiated SOX2-positive cerebellar progenitors. Furthermore, upregulated WNT signaling, altered actin/cytoskeleton organization, and reduced neuronal differentiation were evident in mutant cells. In vitro, cells harboring alterations in both Ctnnb1 and Smarca4 were negatively selected and did not show tumorigenic potential after transplantation in adult recipient mice. However, in cerebellar explant cultures, mutant cells displayed significantly increased proliferation, suggesting an important role of the embryonic microenvironment in the development of lesions. Altogether, these results represent an important first step towards the unravelling of tumorigenic mechanisms induced by aberrant WNT signaling and SMARCA4 deficiency. Whole cerebella of E16.5 embryos (cre-negative controls and Blbpcre::Ctnnb1(ex3)fl/wt::Smarca4fl/fl mutants with cerebellar lesions) were analyzed by single-cell RNA sequencing
Symbol: SMARCA4 loss and mutated beta-catenin induce proliferative lesions in the murine embryonic cerebellum
Name: SMARCA4 loss and mutated beta-catenin induce proliferative lesions in the murine embryonic cerebellum

Id: MGI:5699727
Synonyms: Not Available
Symbol: Smarca4/Smarca4 Tg(Nfat1c-cre)1Bz/0 [background:] involves: 129S2/SvPas (Mmu)
Genes: Smarca4 (Mmu)
Alleles: Smarca4 (Mmu)
Name: Smarca4/Smarca4 Tg(Nfat1c-cre)1Bz/0 [background:] involves: 129S2/SvPas

Id: MGI:3830515
Synonyms: Not Available
Symbol: Smarca4/Smarca4<+> [background:] involves: 129 (Mmu)
Genes: Smarca4 (Mmu)
Alleles: Smarca4 (Mmu)
Name: Smarca4/Smarca4<+> [background:] involves: 129

smarca4aa50 (AB)

(Danio rerio)
Model
Id: ZFIN:ZDB-FISH-150901-19091
Synonyms: Not Available
Symbol: smarca4a (AB) (Dre)
Genes: smarca4a (Dre)

Model
Id: ZFIN:ZDB-FISH-180208-10
Synonyms: Not Available
Symbol: smarca4a; ir937Tg (Dre)
Genes: smarca4a (Dre)

Id: MGI:5699726
Synonyms: Not Available
Symbol: Smarca4/Smarca4 Tg(Tek-cre)1Ywa/0 [background:] involves: 129S2/SvPas * C57BL/6
Genes: Smarca4 (Mmu)
Alleles: Smarca4 (Mmu)
Name: Smarca4/Smarca4 Tg(Tek-cre)1Ywa/0 [background:] involves: 129S2/SvPas * C57BL/6

Model
Id: ZFIN:ZDB-FISH-150901-23130
Synonyms: Not Available
Symbol: smarca4a; s843Tg (Dre)
Genes: smarca4a (Dre)

Id: MGI:5581617
Synonyms: Not Available
Symbol: Smarca4/Smarca4 [background:] involves: 129S6/SvEvTac (Mmu)
Genes: Smarca4 (Mmu)
Alleles: Smarca4 (Mmu)
Name: Smarca4/Smarca4 [background:] involves: 129S6/SvEvTac

Model
Id: ZFIN:ZDB-FISH-150901-18557
Synonyms: Not Available
Symbol: smarca4a; twu34Tg (Dre)
Genes: smarca4a (Dre)