Version: 8.2.0Date: Wed Aug 27 2025
Category
smf-2
(Caenorhabditis elegans)Gene
Name: yeast SMF (divalent cation transporter) homolog 2
Synonyms: K11G12.3, CELE_K11G12.3
Source: WB:WBGene00004877
Biotype: protein coding gene
Symbol: smf-2 (Cel)
Symbol: smf-2
Gene Synopsis: smf-2 encodes one of three C. elegans divalent-metal ion transporters (DMTs) orthologous to the mammalian...DMT1 transporters and Saccharomyces cerevisiae Smf proteins; in C. elegans, SMF-2 appears to function...as both a manganese and iron transporter that regulates metal content; mutations in smf-2 display a...decreased tolerance to manganeseexposure; SMF-2 is expressed mainly in the marginal pharyngeal epithelium...from late embryogenesis through adulthood; SMF-2 localizes primarily to cytoplasmic compartments, with
Cross References: WB:smf-2...smf-2...smf-2
SLC11A1
(Homo sapiens)Gene
Name: solute carrier family 11 member 1
Synonyms: LSH, NRAMP, solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1, solute carrier family 11 (sodium/phosphate symporters), member 1, NRAMP 1, solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1, NRAMP1, Leishmaniasis resistance, natural resistance-associated macrophage protein 1
Source: HGNC:10907
Biotype: protein coding gene
Strict Orthology Symbols: smf-2
SLC11A2
(Homo sapiens)Gene
Name: solute carrier family 11 member 2
Synonyms: AHMIO1, solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2, divalent cation transporter 1, DCT1, DMT1, NRAMP 2, FLJ37416, solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2, DMT-1, NRAMP2, natural resistance-associated macrophage protein 2
Source: HGNC:10908
Biotype: protein coding gene
Strict Orthology Symbols: smf-2
Slc11a2
(Mus musculus)Gene
Name: solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
Synonyms: microcytic anemia, van, DCT1, microcytic anemia, viable anaemia, Dmt1, DMT1, Nramp2, natural resistance-associated macrophage protein 2, mk
Source: MGI:1345279
Biotype: protein coding gene
Strict Orthology Symbols: smf-2
Slc11a1
(Rattus norvegicus)Gene
Name: solute carrier family 11 member 1
Synonyms: Lsh, solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1, MGC124692, Bcg, natural resistance associated macrophage protein 1, NRAMP 1, solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1, Itg, Nramp1, natural resistance-associated macrophage protein 1
Source: RGD:1601463
Biotype: protein coding gene
Strict Orthology Symbols: smf-2
Mvl
(Drosophila melanogaster)Gene
Name: Malvolio
Synonyms: mvl, /Divalent metal transporter, CG3671, DMT1, dNRAMP, malvolio, NRM2
Source: FB:FBgn0011672
Biotype: protein coding gene
Strict Orthology Symbols: smf-2
slc11a2
(Danio rerio)Gene
Name: solute carrier family 11 member 2
Synonyms: nramp, DMT1, chardonnay, cdy, cb426, wu:fa07b10, zgc:136699, fa07b10
Source: ZFIN:ZDB-GENE-021115-1
Biotype: protein coding gene
Strict Orthology Symbols: smf-2
SMF3
(Saccharomyces cerevisiae)Gene
Name: Not Available
Synonyms: YLR034C
Source: SGD:S000004024
Biotype: protein coding gene
Strict Orthology Symbols: smf-2
SMF1
(Saccharomyces cerevisiae)Gene
Name: Suppressor of Mitochondria import Function
Synonyms: YOL122C, SBS1
Source: SGD:S000005482
Biotype: protein coding gene
Strict Orthology Symbols: smf-2
Slc11a1
(Mus musculus)Gene
Name: solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
Synonyms: Nramp, Lsh, Ity1, Bcg, natural resistance-associated macrophage protein, ity, Ity, immunity to S. typhimurium, BCG resistance, host resistance locus Bcg/Ity/Lsh, Itg, Leishmaniasis resistance, natural resistance-associated macrophage protein 1, Nramp1
Source: MGI:1345275
Biotype: protein coding gene
Strict Orthology Symbols: smf-2
SMF2
(Saccharomyces cerevisiae)Gene
Name: Suppressor of Mitochondria import Function
Synonyms: YHR050W
Source: SGD:S000001092
Biotype: protein coding gene
Strict Orthology Symbols: smf-2
slc11a2
(Xenopus tropicalis)Gene
Name: solute carrier family 11 member 2
Synonyms: dct1, dct-1, solute carrier family 11 member 2, dmt1, slc11a2, nramp2
Source: Xenbase:XB-GENE-487563
Biotype: gene
Strict Orthology Symbols: smf-2
slc11a1
(Xenopus tropicalis)Gene
Name: solute carrier family 11 member 1
Synonyms: slc11a1, solute carrier family 11 member 1
Source: Xenbase:XB-GENE-482302
Biotype: gene
Strict Orthology Symbols: smf-2
Source: GO:0046915
Synonyms: Not Available
Branch: molecular function
Genes: smf-2 (Cel)
Disease
Source: DOID:0050456
Definition: A primary bacterial infectious disease that results_in infection located_in skin or located_in subcutaneous tissue, has_material_basis_in Mycobacterium ulcerans, which could be transmitted_by insects. The bacterium produces a toxin, named mycolactone, which causes subcutaneous fat necrosis and inhibits an immune response. The infection has_symptom nodule, which is a painless, mobile swelling in the skin.
Genes: smf-2 (Cel)
Disease
Source: DOID:11759
Definition: An anemia that is characterized by a decrease in the ratio of the weight of hemoglobin to the volume of the erythrocyte. As a result, the red cells have an area of central pallor which is increased in size. The leading cause is iron deficiency.
Genes: smf-2 (Cel)
Gene Ontology
Source: GO:0000041
Synonyms:
- transition metal transport
Branch: biological process
Genes: smf-2 (Cel)
Gene Ontology
Source: GO:0055071
Synonyms:
- manganese homeostasis
Branch: biological process
Genes: smf-2 (Cel)
Gene Ontology
Source: GO:0010042
Synonyms:
- response to manganese
Branch: biological process
Genes: smf-2 (Cel)
Gene Ontology
Source: GO:0030026
Synonyms:
- cellular manganese ion homeostasis
- manganese homeostasis
Branch: biological process
Genes: smf-2 (Cel)
Gene Ontology
Source: GO:0005384
Synonyms: Not Available
Branch: molecular function
Genes: smf-2 (Cel)
Gene Ontology
Source: GO:0006828
Synonyms: Not Available
Branch: biological process
Genes: smf-2 (Cel)
Gene Ontology
Source: GO:0071421
Synonyms:
- manganese ion membrane transport
- transmembrane manganese transport
Branch: biological process
Genes: smf-2 (Cel)
Gene Ontology
Source: GO:0034755
Synonyms:
- ferrous ion transmembrane transport
- ferrous iron transmembrane transport
Branch: biological process
Genes: smf-2 (Cel)
Gene Ontology
Source: GO:0005381
Synonyms:
- iron cation channel activity
- iron channel activity
Branch: molecular function
Genes: smf-2 (Cel)
Disease
Source: DOID:0060704
Definition: A primary immunodeficiency disease characterized by immune dysregulation typically after viral infection, usually associated with Epstein-Barr viral infection.
Genes: smf-2 (Cel)
Disease
Source: DOID:1024
Definition: A primary bacterial infectious disease that results_in infection located_in superficial peripheral nerves, located_in skin, located_in mucous membranes of the upper respiratory tract, located_in anterior chamber of the eyes, or located_in testes, has_material_basis_in Mycobacterium leprae, which is transmitted_by aerosol spread from infected nasal secretions to exposed nasal and oral mucosa. The infection has_symptom skin lesions, has_symptom sensory loss, has_symptom motor loss and has_symptom eye damage.
Genes: smf-2 (Cel)
Disease
Source: DOID:0050425
Definition: A central nervous system disease characterized by throbbing, pulling creeping or other unpleasant sensations in the legs and the irresistible urge to move them.
Genes: smf-2 (Cel)
Gene Ontology
Source: GO:0010038
Synonyms:
- heavy metal sensitivity/resistance
- response to heavy metal
Branch: biological process
Genes: smf-2 (Cel)
Disease
Source: DOID:9146
Definition: A leishmaniasis that is the most severe form of the disease caused by protozoan parasites of the Leishmania genus, resulting in the infection of the internal organs such as liver, spleen and bone marrow. The symptoms include fever, weight loss, and an enlarged spleen and liver.
Genes: smf-2 (Cel)
Disease
Source: DOID:9111
Definition: A leishmaniasis that involves skin infection caused by Leishmania species, resulting in one or more cutaneous lesions.
Genes: smf-2 (Cel)
Gene Ontology
Source: GO:0046873
Synonyms:
- heavy metal ion porter activity
- heavy metal ion transporter activity
Branch: molecular function
Genes: smf-2 (Cel)
Gene Ontology
Source: GO:0030001
Synonyms:
- divalent metal ion export
- divalent metal ion transport
Branch: biological process
Genes: smf-2 (Cel)
Source: DOID:676
Definition: A rheumatoid arthritis that involves an autoimmune disease onset in children under 16 which attacks the healthy cells and tissue of located_in joint.
Genes: smf-2 (Cel)
Disease
Source: DOID:11335
Definition: A hypersensitivity reaction type IV disease characterized by the growth of collections of inflammatory cells (granulomas) in multiple organs.
Genes: smf-2 (Cel)
Disease
Source: DOID:2355
Definition: A hematopoietic system disease that is characterized by a decrease in the normal number of red blood cells.
Genes: smf-2 (Cel)
Gene Ontology
Source: GO:0006879
Synonyms:
- cellular iron ion homeostasis
- iron homeostasis
Branch: biological process
Genes: smf-2 (Cel)
Disease
Source: DOID:399
Definition: A primary bacterial infectious disease that is located_in lungs, located_in lymph nodes, located_in pericardium, located_in brain, located_in pleura or located_in gastrointestinal tract, has_material_basis_in Mycobacterium tuberculosis, which is transmitted_by droplets released into the air when an infected person coughs or sneezes.
Genes: smf-2 (Cel)
Disease
Source: DOID:0050589
Definition: An intestinal disease characterized by inflammation located in all parts of digestive tract.
Genes: smf-2 (Cel)
Disease
Source: DOID:13241
Definition: A vasculitis that is characterized by an autoimmune mediated inflammation of the blood vessels throughout the body leading to ulcerations on the mouth and sometimes the genitals, notorious for causing hypopyon uveitis.
Genes: smf-2 (Cel)
Disease
Source: DOID:2957
Definition: A tuberculosis that is a contagious disease located_in lungs. The infection has_symptom fever, has_symptom cough, has_symptom difficulty in breathing, has_symptom inflammatory infiltrations, has_symptom formation of tubercles, has_symptom caseation, has_symptom pleural effusion, and has_symptom fibrosis.
Genes: smf-2 (Cel)
Disease
Source: DOID:2377
Definition: A demyelinating disease that involves damage to the fatty myelin sheaths around the axons of the brain and spinal cord resulting in demyelination and scarring.
Genes: smf-2 (Cel)
Disease
Source: DOID:8778
Definition: An intestinal disease that involves inflammation located_in intestine.
Genes: smf-2 (Cel)
Disease
Source: DOID:8577
Definition: A colitis that is predominantly confined to the mucosa located_in colon and includes characteristic ulcers, or open sores.
Genes: smf-2 (Cel)
Disease
Source: DOID:7148
Definition: An arthritis that is an autoimmune disease which attacks healthy cells and tissue located_in joint.
Genes: smf-2 (Cel)
Disease
Source: DOID:418
Definition: A scleroderma that is characterized by fibrosis (or hardening) of the skin and major organs, as well as vascular alterations, and autoantibodies.
Genes: smf-2 (Cel)
Gene Ontology
Source: GO:0030659
Synonyms: Not Available
Branch: cellular component
Genes: smf-2 (Cel)
Source: DOID:332
Definition: A motor neuron disease that is characterized by muscle spasticity, rapidly progressive weakness due to muscle atrophy, difficulty in speaking, swallowing, and breathing.
Genes: smf-2 (Cel)
Disease
Source: DOID:9744
Definition: A diabetes mellitus that is characterized by destruction of pancreatic beta cells resulting in absent or extremely low insulin production.
Genes: smf-2 (Cel)