Gene

mew

Species
Drosophila melanogaster
Symbol
mew
Name
multiple edematous wings
Synonyms
  • alpha integrin
  • alpha-PS1
Biotype
protein coding gene
Automated Description
Enables cell adhesion molecule binding activity; extracellular matrix binding activity; and protein heterodimerization activity. Involved in several processes, including axon development; maintenance of epithelial integrity, open tracheal system; and salivary gland development. Located in several cellular components, including basal plasma membrane; focal adhesion; and lateral plasma membrane. Part of integrin complex. Is expressed in several structures, including embryonic/larval midgut primordium; epithelium; follicle cell; gut section; and larval visceral muscle cell. Human ortholog(s) of this gene implicated in Duchenne muscular dystrophy; congenital muscular dystrophy due to integrin alpha-7 deficiency; junctional epidermolysis bullosa; junctional epidermolysis bullosa with pyloric atresia; and muscular disease. Orthologous to several human genes including ITGA6 (integrin subunit alpha 6) and ITGA7 (integrin subunit alpha 7).
FB Description
multiple edematous wings (mew) encodes one of 5 fly integrin alpha subunits, and when in a heterodimer with an integrin beta subunit makes a receptor for the extracellular matrix protein laminin. It is required in numerous tissues for cell migration, adhesion between cell layers, and cell differentiation.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23220
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
if1148239243 of 8  
scb2120942243 of 8  
ItgaPS43118740243 of 8  
ItgaPS54117040233 of 8  

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
abnormal neuroanatomy
abnormal size | adult stage | somatic clone
adult posterior midgut epithelium | somatic clone
anterior midgut primordium
decreased cell number | adult stage | somatic clone
embryonic midgut constriction
embryonic/larval midgut
embryonic/larval midgut | embryonic stage
embryonic/larval salivary gland
embryonic/larval visceral tracheal branch
Showing 1 - 10 of 40 rows
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
R6
Viewer Help
13.215M13.220M13.225M13.230M13.235M13.240M13.245M13.250M13.255M
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
mewG0078a
  • mew[G0078a]
allele
mewH7
  • mew[H7]
  • mew[H7/H10]
allele
Yes
mewH10
  • mew[H10]
  • mew[H7/H10]
allele
Yes
mew134
  • mew[134]
allele
Yes
mewunspecified
  • mew[unspecified]
allele
mewP13
  • mew[P13]
allele
Yes
mew24xMS2
  • mew[24xMS2]
allele
mewA1-5
  • mew[A1-5]
allele
Yes
mewPG30
  • mew[PG30]
allele
Yes
mew023
  • mew[023]
allele
Yes
Showing 1 - 10 of 1,469 rows
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Transgenic Alleles

Species
(carrying the transgene)
Allele symbol
Transgenic construct
Expressed components
Knock-down targets
Regulatory regions
Has Disease Annotations
Has Phenotype Annotations
Drosophila melanogastermewGD1230
  • UASt
Drosophila melanogastermewHMS02849
  • UAS
Drosophila melanogastermewJF02694
  • UAS
Drosophila melanogastermewKK101081
  • UASt
Drosophila melanogastermewNIG.1771R
  • UASt
Drosophila melanogastermewTKO.GS00808
Drosophila melanogastermewTOE.GS02482
Drosophila melanogastermewUAS.cMBa
  • UAS
Drosophila melanogastermewUAS.cMBb
  • UAS
Drosophila melanogastermewUAS.cUa
  • UAS
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Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
13.215M13.220M13.225M13.230M13.235M13.240M13.245M13.250M13.255Mmew-RA (mew)mew-RB (mew)mew-RC (mew)mew-RD (mew)mew-RE (mew)mew-RF (mew)CG32639-RA (CG32639)CG15742-RA (CG15742)CG15742-RB (CG15742)CG15742-RC (CG15742)Maximum features displayed. See full view for more.

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

17 interactor genes based on 26 annotations
mew molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
konDrosophila melanogaster
protein
  • bead aggregation assay
PMID:28104814
protein
mysDrosophila melanogaster
protein
  • anti bait coimmunoprecipitation
PMID:7972082
protein
mysDrosophila melanogaster
protein
  • anti tag coimmunoprecipitation
PMID:36087584
protein
rheaDrosophila melanogaster
protein
  • anti tag coimmunoprecipitation
PMID:36087584
protein
sogDrosophila melanogaster
protein
  • anti bait coimmunoprecipitation
PMID:12835400
protein
tkvDrosophila melanogaster
protein
  • anti bait coimmunoprecipitation
PMID:26321638
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Genetic Interactions

mew role
mew genetic perturbation
Interactor gene
Interactor species
Interactor role
Interactor genetic perturbation
Interaction type
Phenotype or trait
Source
Reference
suppressor gene
14-3-3εDrosophila melanogaster
suppressed gene
genetic suppression
    PMID:22500634
    enhanced gene
    bloDrosophila melanogaster
    enhancer gene
    genetic enhancement
      PMID:9755209
      enhanced gene
      bsDrosophila melanogaster
      enhancer gene
      genetic enhancement
        PMID:9755209
        enhancer gene
        fraDrosophila melanogaster
        enhanced gene
        genetic enhancement
          PMID:15950216
          suppressor gene
          HDrosophila melanogaster
          suppressed gene
          genetic suppression
            PMID:16118195
            suppressed gene
            ifDrosophila melanogaster
            suppressor gene
            genetic suppression
              PMID:9250662
              suppressed gene
              ifDrosophila melanogaster
              suppressor gene
              genetic suppression
                PMID:8674437
                suppressed gene
                ifDrosophila melanogaster
                suppressor gene
                genetic suppression
                  PMID:9435290
                  enhancer gene
                  ifDrosophila melanogaster
                  enhanced gene
                  genetic enhancement
                    PMID:9527881
                    suppressor gene
                    ifDrosophila melanogaster
                    suppressed gene
                    genetic suppression
                      PMID:9250662
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