Gene

Hic2

Species
Rattus norvegicus
Symbol
Hic2
Name
HIC ZBTB transcriptional repressor 2
Synonyms
  • hypermethylated in cancer 2
  • LOC287940
Biotype
protein coding gene
Automated Description
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be located in nucleus and plasma membrane. Predicted to be active in nucleoplasm. Orthologous to human HIC2 (HIC ZBTB transcriptional repressor 2).
RGD Description
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be located in nucleus and plasma membrane. Predicted to be active in nucleoplasm. Orthologous to human HIC2 (HIC ZBTB transcriptional repressor 2); INTERACTS WITH 17beta-estradiol; 6-propyl-2-thiouracil; acrylamide.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24394
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Hic1165353464 of 9 
Zbtb11280635222 of 9 
Zbtb1375635243 of 9 
Zbtb49466439283 of 9 
Bcl6570340252 of 9 
Zbtb20670737233 of 9 
Zbtb17768138262 of 9 
Zbtb18863640262 of 9 
Zbtb48976832222 of 9 
Zbtb451065436243 of 9 
Zbtb241163937253 of 9 
Gzf11267437242 of 9 
Zbtb371362237263 of 9 
Zbtb221469034242 of 9 
Zbtb441566035252 of 9 
Zbtb421662435243 of 9 
Zbtb341761138233 of 9 
Mynn1861637252 of 9 
Zbtb431961836262 of 9 
Patz12063734223 of 9 
Zbtb22166132223 of 9 
Bcl6b2263432232 of 9 
Zbtb122363432213 of 9 
Zbtb142460033213 of 9 
Zbtb7c2563832222 of 9 
Zbtb62659232203 of 9 
Zbtb262760131183 of 9 
Zfp1312863428202 of 9 
Gfi1b2935835242 of 9 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Transgenic Alleles

No data available

Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
83.740M83.745M83.750M83.755M83.760M83.765M83.770M83.775M83.780M83.785M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

No data available

Genetic Interactions

No data available