Species

Saccharomyces cerevisiae

Symbol

AKL1

Name

Ark family Kinase-Like protein

Synonyms

YBR059C

Biotype

protein coding gene

Automated Description

Enables protein serine/threonine kinase activity. Involved in negative regulation of clathrin-dependent endocytosis. Located in several cellular components, including cell periphery; cellular bud neck; and prospore membrane. Orthologous to human BMP2K (BMP2 inducible kinase).

SGD Description

Ser/Thr protein kinase; phosphorylates Pan1p, Sla1p and Ent1p to negatively regulate endocytosis in response to membrane stress; regulates actin cytoskeleton organization and clathrin-dependent endocytosis; phosphorylated and inhibited by upstream kinase, Fpk1p; member, along with Ark1p and Prk1p, of the Ark kinase family

Cross References

Additional Information

Literature

Orthology

Gene tree: PANTHER:PTHR22967:SF65

Stringency:StringentModerateNo filter

Additional filters to further constrain the results:

Best Score OnlyBest Reverse Score Only

Count:Species:Methods:

Species	Gene symbol	Count	Best	Best reverse	Method Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiens	BMP2K	4 of 9	Yes	No	☑ ☐☑☐☐☑☑☐☐
Mus musculus	Bmp2k	4 of 9	Yes	No	☑ ☐☑☐☐☑☑☐☐
Rattus norvegicus	Aak1	3 of 9	Yes	No	☐ ☐☑☐☐☑☑☐☐
Rattus norvegicus	Bmp2k	3 of 9	Yes	No	☑ ☐☑☐☐☐☑☐☐
Xenopus tropicalis	aak1	3 of 9	Yes	No	☐ ☐☐☐☐☑☑☑☐
Danio rerio	aak1a	5 of 9	Yes	No	☑ ☐☑☐☐☑☑☑☐
Drosophila melanogaster	Nak	4 of 9	Yes	No	☑ ☐☑☐☐☑☑☐☐
Caenorhabditis elegans	sel-5	3 of 9	Yes	No	☑ ☐☐☐☐☑☑☐☐

Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse

Paralogy

No paralogs for the gene.

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources

SGD

Other Sources

None

Phenotype Term

Annotation details

References

abnormal protein/peptide distribution

View

PMID:28069741

abnormal vacuolar morphology

View

PMID:23383298

abnormal vegetative growth

View

PMID:12432101

decreased competitive fitness

View

Name	Type	Experimental condition	References
akl1-Δ	allele	has condition: media: minimal medium	PMID:18622397
akl1-Δ	allele	has condition: media: synthetic oak exudate medium, OAK	PMID:23103169
akl1-Δ	allele	has condition: media: synthetic complete medium, SC	PMID:23103169
AKL1	gene		PMID:23050238 PMID:23103169

decreased endocytosis

View

decreased heat sensitivity

View

PMID:21814286

decreased rate vegetative growth

View

PMID:21341307

decreased resistance to chemicals

View

Name	Type	Experimental condition	References
akl1-Δ	allele	has condition: chemical: doxorubicin	PMID:19503795 PMID:26690737
akl1-Δ	allele	has condition: chemical: glycolaldehyde	PMID:20960220
akl1-Δ	allele	has condition: chemical: aflatoxin B1	PMID:32994210
akl1-Δ	allele	has condition: chemical: N-nitrosodiethylamine	PMID:34127714
akl1-Δ	allele	has condition: chemical: gadolinium(3+)	PMID:36519157

decreased stress resistance

View

PMID:33198745

decreased vegetative growth

View

PMID:16455487

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Disease Associations

Must provide at least one subject

Cell color indicative of annotation volume

Species	Gene	Association	Disease Qualifier	Disease	Evidence	Source	Based On	References
No records match query. Try removing filters.

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Alleles and Variants

Genome location

ChrII:356861...360187 - (3.33 kb)

Assembly version

R64-5-1

Viewer Help

Data currently unavailable; sequence viewer under construction

Allele/Variant Symbol	Allele Synonyms	Category	Variant
akl1-Δ	akl1-delta	allele		Yes
Akl1-S960A/S1072A		allele		Yes
akl1-AA		allele		Yes
akl1-S176P		allele
NC_001134.8:g.356897C>T		variant	NC_001134.8:g.356897C>T SNP synonymous variant
NC_001134.8:g.358948G>A		variant	NC_001134.8:g.358948G>A SNP missense variant
NC_001134.8:g.359116G>A		variant	NC_001134.8:g.359116G>A SNP synonymous variant
NC_001134.8:g.358555A>G		variant	NC_001134.8:g.358555A>G SNP synonymous variant
NC_001134.8:g.359662A>G		variant	NC_001134.8:g.359662A>G SNP missense variant
NC_001134.8:g.357338G>A		variant	NC_001134.8:g.357338G>A SNP synonymous variant

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View detailed Alleles/Variants information

Download all Alleles/Variants for all genes of the species

Transgenic Alleles

No data available

Models

No data available

Sequence Feature Viewer

Genome location

ChrII:356861...360187 - (3.33 kb)

Assembly version

R64-5-1

Viewer Help

Data currently unavailable; sequence viewer under construction

Sequence Details

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Expression

Primary Sources

Other Sources

Must provide at least one subject

Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

223 interactor genes based on 274 annotations

AKL1 molecule type	Interactor gene	Interactor species	Interactor molecule type	Detection methods	Source	Reference
protein	ABP140	Saccharomyces cerevisiae	protein	enzymatic study	biogrid:197751	PMID:16319894
protein	ADE57	Saccharomyces cerevisiae	protein	enzymatic study	biogrid:197759	PMID:16319894
protein	AIM10	Saccharomyces cerevisiae	protein	pull down	biogrid:520140	PMID:21460040
protein	AKL1	Saccharomyces cerevisiae	protein	two hybrid	biogrid:237154	PMID:11283351
protein	ALY2	Saccharomyces cerevisiae	protein	enzymatic study	biogrid:197763	PMID:16319894
protein	ARA1	Saccharomyces cerevisiae	protein	affinity chromatography technology	biogrid:3617774	PMID:37968396
protein	ARC1	Saccharomyces cerevisiae	protein	enzymatic study	biogrid:197744	PMID:16319894
protein	ARK1	Saccharomyces cerevisiae	protein	affinity chromatography technology	biogrid:439190	PMID:20489023
protein	ART10	Saccharomyces cerevisiae	protein	pull down	biogrid:520162	PMID:21460040
protein	ATG8	Saccharomyces cerevisiae	protein	proximity labelling technology	biogrid:3717737	PMID:38958087

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Genetic Interactions

AKL1 role	Interactor gene	Interactor species	Interactor role	Interaction type	Phenotype or trait	Source	Reference
unspecified role	ACT1	Saccharomyces cerevisiae	unspecified role	positive genetic interaction (sensu BioGRID)	colony size	biogrid:1893820	PMID:27708008
unspecified role	ARP6	Saccharomyces cerevisiae	unspecified role	synthetic growth defect (sensu BioGRID)	vegetative growth	biogrid:450730	PMID:14764870
unspecified role	BAS1	Saccharomyces cerevisiae	unspecified role	positive genetic interaction (sensu BioGRID)	colony size resistance to chemicals	biogrid:540596	PMID:21127252
unspecified role	BEM1	Saccharomyces cerevisiae	unspecified role	negative genetic interaction (sensu BioGRID)	colony size	biogrid:322235	PMID:19269370
unspecified role	BRE1	Saccharomyces cerevisiae	unspecified role	negative genetic interaction (sensu BioGRID)	colony size	biogrid:2080325	PMID:27708008
unspecified role	BRE4	Saccharomyces cerevisiae	unspecified role	negative genetic interaction (sensu BioGRID)	colony size	biogrid:357255	PMID:20093466
unspecified role	BRE4	Saccharomyces cerevisiae	unspecified role	negative genetic interaction (sensu BioGRID)	colony size vegetative growth	biogrid:911798	PMID:22282571
unspecified role	CBF1	Saccharomyces cerevisiae	unspecified role	negative genetic interaction (sensu BioGRID)	colony size	biogrid:541330	PMID:21127252
unspecified role	CDC1	Saccharomyces cerevisiae	unspecified role	negative genetic interaction (sensu BioGRID)	colony size	biogrid:2028376	PMID:27708008
unspecified role	CDC13	Saccharomyces cerevisiae	unspecified role	negative genetic interaction (sensu BioGRID)	vegetative growth	biogrid:808820	PMID:21490951

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