Version: 8.0.0Date: Tue Jan 28 2025
Gene Biological Process: telomere maintenance
ATM
(Homo sapiens)Gene
Name: ATM serine/threonine kinase
Synonyms: serine/threonine kinase ATM, TEL1, telomere maintenance 1, homolog, MGC74674, human phosphatidylinositol 3-kinase homolog, ATDC, truncated ATM serine/threonine kinase, DKFZp781A0353, ATA, AT mutated, ATC, ataxia telangiectasia mutated, ATD, TEL1, ataxia telangiectasia mutated (includes complementation groups A, C and D), ATE, A-T mutated, serine-protein kinase ATM, TELO1, AT1
Source: HGNC:795
Biotype: protein coding gene
BRCA2
(Homo sapiens)Gene
Name: BRCA2 DNA repair associated
Synonyms: truncated breast and ovarian cancer susceptibility protein 2, DNA repair-associated BRCA2, FAD1, truncated DNA repair-associated BRCA2, BRCC2, GLM3, BRCA2, DNA repair associated, BRCA1/BRCA2-containing complex, subunit 2, breast cancer type 2 susceptibility protein, breast cancer 2, early onset, breast cancer 2 tumor suppressor, breast and ovarian cancer susceptibility gene, early onset, PNCA2, truncated BRCA2 DNA repair associated, fanconi anemia group D1 protein, truncated breast cancer 2, FAD, mutant BRCA2, breast cancer susceptibility protein BRCA2, FANCB, FANCD, breast and ovarian cancer susceptibility protein 2, mutant DNA repair-associated protein 2, FANCD1, BROVCA2, XRCC11, breast cancer 2, FACD
Source: HGNC:1101
Biotype: protein coding gene
MRE11
(Homo sapiens)Gene
Name: MRE11 homolog, double strand break repair nuclease
Synonyms: HNGS1, double-strand break repair protein MRE11A, MRE11 homolog A, DNA recombination and repair protein, MRE11A, MRE11B, endo/exonuclease Mre11, meiotic recombination 11 homolog A, double-strand break repair protein MRE11, MRE11 meiotic recombination 11-like protein A, MRE11 homolog A, double strand break repair nuclease, MRE11 meiotic recombination 11 homolog A, ATLD, AT-like disease, MRE11 homolog 1, MRE11 double strand break repair nuclease A, MRE11 homolog, double strand break repair nuclease A, meiotic recombination 11 homolog 1
Source: HGNC:7230
Biotype: protein coding gene
HSPA1A
(Homo sapiens)Gene
Name: heat shock protein family A (Hsp70) member 1A
Synonyms: HSP70-2, HSP70-1, epididymis secretory protein Li 103, HSP70-1A, FLJ54303, FLJ75127, FLJ54408, heat shock 70kD protein 1A, heat shock 70 kDa protein 1/2, HSP70.1/HSP70.2, HSP70I, heat shock-induced protein, HSP72, dnaK-type molecular chaperone HSP70-1, HSP70.2, HSP70.1, HSP70, heat shock 70 kDa protein 1A, Heat shock 70 kDa protein 1B, HEL-S-103, HSPA1, heat shock 70kDa protein 1A, HSP70-1/HSP70-2, Heat shock 70 kDa protein 2, heat shock 70 kDa protein 1A/1B, heat shock 70 kDa protein 1, FLJ54392, FLJ54370, heat shock protein family A member 1A, HSPA1B
Source: HGNC:5232
Biotype: protein coding gene
SGS1
(Saccharomyces cerevisiae)Gene
Name: Slow Growth Suppressor
Synonyms: YMR190C
Source: SGD:S000004802
Biotype: protein coding gene
ATR
(Homo sapiens)Gene
Name: ATR serine/threonine kinase
Synonyms: FRAP-related protein 1, MEC1, ataxia telangiectasia and Rad3-related protein, MEC1, mitosis entry checkpoint 1, homolog, ataxia telangiectasia and Rad3 related, FRAP-related protein-1, FRP1, SCKL1, serine/threonine-protein kinase ATR, protein kinase ATR, SCKL, Rad3 related protein, FCTCS
Source: HGNC:882
Biotype: protein coding gene
Brca2
(Mus musculus)Gene
Name: breast cancer 2, early onset
Synonyms: expressed sequence AW045498, AW045498, Fancd1, expressed sequence AI256696, AI256696, RAB163
Source: MGI:109337
Biotype: protein coding gene
DNA2
(Homo sapiens)Gene
Name: DNA replication helicase/nuclease 2
Synonyms: RTS4, MGC133297, DNA replication helicase 2 homolog, PEOA6, DNA2 (DNA replication helicase, yeast, homolog)-like, DNA2 DNA replication helicase 2-like, KIAA0083, FLJ10063, DNA replication ATP-dependent helicase/nuclease DNA2, DNA2L, DNA2-like helicase, SCKL8, hDNA2, DNA replication ATP-dependent helicase-like homolog
Source: HGNC:2939
Biotype: protein coding gene
PIF1
(Homo sapiens)Gene
Name: PIF1 5'-to-3' DNA helicase
Synonyms: ATP-dependent DNA helicase PIF1, DNA helicase PIF1, PIF1/RRM3 DNA helicase-like protein, petite integration frequency 1, C15orf20, PIF1 5'-to-3' DNA helicase homolog, chromosome 15 open reading frame 20, DNA helicase homolog PIF1, PIF1 DNA helicase, DNA repair and recombination helicase PIF1, PIF
Source: HGNC:26220
Biotype: protein coding gene
TEL1
(Saccharomyces cerevisiae)Gene
Name: TELomere maintenance
Synonyms: YBL088C
Source: SGD:S000000184
Biotype: protein coding gene
TLC1
(Saccharomyces cerevisiae)Gene
Name: TeLomerase Component
Synonyms: YNCB0010W, TER1
Source: SGD:S000006657
Biotype: telomerase RNA gene
APEX1
(Homo sapiens)Gene
Name: apurinic/apyrimidinic endodeoxyribonuclease 1
Synonyms: DNA repair nuclease/redox regulator APEX1, redox factor-1, multifunctional DNA repair enzyme, deoxyribonuclease (apurinic or apyrimidinic), AP endonuclease 1, DNA-(apurinic or apyrimidinic site) lyase, APE1, APEN, DNA-(apurinic or apyrimidinic site) endonuclease, apurinic-apyrimidinic endonuclease 1, APX, apurinic/apyrimidinic exonuclease, AP lyase, AP endonuclease class I, APE, APEX nuclease (multifunctional DNA repair enzyme) 1, apurinic/apyrimidinic (abasic) endonuclease, REF1, HAP1, protein REF-1, APEX, redox factor 1
Source: HGNC:587
Biotype: protein coding gene
TERT
(Homo sapiens)Gene
Name: telomerase reverse transcriptase
Synonyms: TP2, TRT, telomerase-associated protein 2, PFBMFT1, CMM9, telomerase catalytic subunit, TCS1, EST2, DKCA2, hEST2, hTRT, DKCB4
Source: HGNC:11730
Biotype: protein coding gene
HSP90AB1
(Homo sapiens)Gene
Name: heat shock protein 90 alpha family class B member 1
Synonyms: heat shock protein 90kDa alpha family class B member 1, HSP 90, FLJ26984, D6S182, heat shock protein family C member 3, HSP 84, heat shock protein HSP 90-beta, HSP90 beta, HSPC2, heat shock 84 kDa, 90-kda heat shock protein beta, HSP90B, heat shock protein beta, HSPCB, HSP90-BETA, heat shock 90kD protein 1, beta, heat shock protein 90 kDa, HSP84, 90-kda heat shock protein beta HSP90 beta, heat shock protein 90kDa alpha (cytosolic), class B member 1
Source: HGNC:5258
Biotype: protein coding gene
tefu
(Drosophila melanogaster)Gene
Name: telomere fusion
Synonyms: atm/tefu, Tefu, ataxia telengiesctasia mutated, Drosophila ATM, ataxia telangiectasia mutated, CG6535, tef, A-T mutated, dATM, tefu/atm, ataxia-telangiectasia mutated, ATM, Ataxia Telangectasia Mutated, atm, Atm
Source: FB:FBgn0045035
Biotype: protein coding gene
RAD50
(Homo sapiens)Gene
Name: RAD50 double strand break repair protein
Synonyms: hRad50, DNA repair protein RAD50, RAD502, RAD50-2, RAD50 homolog, NBSLD
Source: HGNC:9816
Biotype: protein coding gene
PPP1CA
(Homo sapiens)Gene
Name: protein phosphatase 1 catalytic subunit alpha
Synonyms: PP-1A, testicular tissue protein Li 155, MGC1674, PP1A, serine/threonine protein phosphatase PP1-alpha 1 catalytic subunit, PP1alpha, PPP1A, serine/threonine-protein phosphatase PP1-alpha catalytic subunit, MGC15877, protein phosphatase 1, catalytic subunit, alpha isoform
Source: HGNC:9281
Biotype: protein coding gene
HEK2
(Saccharomyces cerevisiae)Gene
Name: HEterogeneous nuclear rnp K-like gene
Synonyms: KHD1, YBL032W
Source: SGD:S000000128
Biotype: protein coding gene
HSP90AA1
(Homo sapiens)Gene
Name: heat shock protein 90 alpha family class A member 1
Synonyms: heat shock 86 kDa, heat shock protein family C member 1, HSP90N, HSPCAL1, heat shock 90kDa protein 1, alpha, HSPCAL4, HEL-S-65p, heat shock 90kD protein 1, alpha-like 4, epididymis luminal secretory protein 52, HSP89A, HSP 86, Hsp89, FLJ31884, Hsp103, lipopolysaccharide-associated protein 2, Hsp90, heat shock protein 90kDa alpha (cytosolic), class A member 1, HSP90A, heat shock protein 90kDa alpha family class A member 1, HSPCA, LPS-associated protein 2, heat shock protein HSP 90-alpha, EL52, heat shock 90kD protein 1, alpha, HSPN, LAP-2, HSPC1, renal carcinoma antigen NY-REN-38, LAP2, heat shock 90kD protein, alpha-like 4, heat shock 90kDa protein 1, alpha-like 4, epididymis secretory sperm binding protein Li 65p, HSP86
Source: HGNC:5253
Biotype: protein coding gene
Parp1
(Mus musculus)Gene
Name: poly (ADP-ribose) polymerase family, member 1
Synonyms: poly (ADP-ribose) polymerase, Adprt1, Parp-1, expressed sequence AI893648, Adprp, PARP, ARTD1, sPARP-1, Adprt, AI893648, RIKEN cDNA 5830444G22 gene, parp-1, 5830444G22Rik, C80510, expressed sequence C80510, ADP-ribosyltransferase (NAD+, poly (ADP-ribose) polymerase) 1
Source: MGI:1340806
Biotype: protein coding gene
Prkdc
(Mus musculus)Gene
Name: protein kinase, DNA activated, catalytic polypeptide
Synonyms: DNAPDcs, DNA-PKcs, doxorubicin nephropathy, XRCC7, DNA-PK, expressed sequence AI326420, AU019811, dxnph, severe combined immunodeficiency, DOXNPH, expressed sequence AU019811, slip, AI326420, scid
Source: MGI:104779
Biotype: protein coding gene
WRN
(Homo sapiens)Gene
Name: WRN RecQ like helicase
Synonyms: RECQ3, RECQL3, Werner syndrome RecQ like helicase, bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, Werner syndrome, RecQ helicase-like, recQ protein-like 2, exonuclease WRN, DNA helicase, RecQ-like type 3, DKFZp686C2056, RECQL2, Werner syndrome ATP-dependent helicase
Source: HGNC:12791
Biotype: protein coding gene
BLM
(Homo sapiens)Gene
Name: BLM RecQ like helicase
Synonyms: MGRISCE1, Bloom syndrome RecQ like helicase, MGC131620, recQ-like DNA helicase BLM, Bloom syndrome, RecQ helicase-like, MGC126616, RECQL3, BS, RECQ2, Bloom syndrome protein, recQ protein-like 3, DNA helicase, RecQ-like type 2, MGC131618, DNA 3'-5' helicase BLM, RECQL2
Source: HGNC:1058
Biotype: protein coding gene
SAE2
(Saccharomyces cerevisiae)Gene
Name: Sporulation in the Absence of spo Eleven
Synonyms: YGL175C, COM1
Source: SGD:S000003143
Biotype: protein coding gene
PRKDC
(Homo sapiens)Gene
Name: protein kinase, DNA-activated, catalytic subunit
Synonyms: HYRC, DNA-PKcs, DNAPKc, XRCC7, DNA-PK catalytic subunit, DNA-dependent protein kinase catalytic subunit, IMD26, p460, p350, DNPK1, HYRC1, DNAPK, DNA-PKC, hyper-radiosensitivity of murine scid mutation, complementing 1
Source: HGNC:9413
Biotype: protein coding gene
INO80
(Saccharomyces cerevisiae)Gene
Name: INOsitol requiring
Synonyms: YGL150C
Source: SGD:S000003118
Biotype: protein coding gene
PCNA
(Homo sapiens)Gene
Name: proliferating cell nuclear antigen
Synonyms: cyclin, DNA polymerase delta auxiliary protein, MGC8367, ATLD2
Source: HGNC:8729
Biotype: protein coding gene
MRC1
(Saccharomyces cerevisiae)Gene
Name: Mediator of the Replication Checkpoint
Synonyms: YCL061C, YCL060C
Source: SGD:S000000566
Biotype: protein coding gene
Hspa1a
(Mus musculus)Gene
Name: heat shock protein 1A
Synonyms: HSP70-2, HSP70.2, HSP70-1, Hsp70-2, Hsp70.3, HSP70.1, heat shock protein, 70 kDa 3, HSP70, Hsp70-1, Hsp70-3, Hsp68, Hsp72, Hsp70a1, Hspa1, Hspa2, HSP72
Source: MGI:96244
Biotype: protein coding gene
Recql4
(Mus musculus)Gene
Name: RecQ protein-like 4
Synonyms: Not Available
Source: MGI:1931028
Biotype: protein coding gene
XRS2
(Saccharomyces cerevisiae)Gene
Name: X-Ray Sensitive
Synonyms: YDR369C
Source: SGD:S000002777
Biotype: protein coding gene
DNA2
(Saccharomyces cerevisiae)Gene
Name: DNA synthesis defective
Synonyms: YHR164C, WEB2
Source: SGD:S000001207
Biotype: protein coding gene
SET1
(Saccharomyces cerevisiae)Gene
Name: SET domain-containing
Synonyms: KMT2, YHR119W, YTX1
Source: SGD:S000001161
Biotype: protein coding gene
RAD51
(Saccharomyces cerevisiae)Gene
Name: RADiation sensitive
Synonyms: YER095W, MUT5
Source: SGD:S000000897
Biotype: protein coding gene
MRE11
(Saccharomyces cerevisiae)Gene
Name: Meiotic REcombination
Synonyms: XRS4, NGS1, YMR224C, RAD58
Source: SGD:S000004837
Biotype: protein coding gene
Apex1
(Mus musculus)Gene
Name: apurinic/apyrimidinic endonuclease 1
Synonyms: REF-1, Ref-1, APE, HAP1, Apex
Source: MGI:88042
Biotype: protein coding gene
atl-1
(Caenorhabditis elegans)Gene
Name: ATM (ataxia telangectasia mutated)-Like 1
Synonyms: Ce-atl1, T06E4.3, CELE_T06E4.3
Source: WB:WBGene00000226
Biotype: protein coding gene
GLC7
(Saccharomyces cerevisiae)Gene
Name: GLyCogen
Synonyms: PP1, DIS2, DIS2S1, CID1, YER133W
Source: SGD:S000000935
Biotype: protein coding gene
CDC13
(Saccharomyces cerevisiae)Gene
Name: Cell Division Cycle
Synonyms: YDL220C, EST4
Source: SGD:S000002379
Biotype: protein coding gene
Hsp90aa1
(Mus musculus)Gene
Name: heat shock protein 90, alpha (cytosolic), class A member 1
Synonyms: Hsp86-1, AL024080, heat shock protein, AL024147, expressed sequence AL024080, Hsp89, heat shock protein, 90 kDa, Hspca, Hsp86, Hsp90, heat shock protein, 1, heat shock protein 1, alpha, hsp4, expressed sequence AL024147
Source: MGI:96250
Biotype: protein coding gene
MEC1
(Saccharomyces cerevisiae)Gene
Name: Mitosis Entry Checkpoint
Synonyms: RAD31, YBR136W, SAD3, ESR1
Source: SGD:S000000340
Biotype: protein coding gene
RAD50
(Saccharomyces cerevisiae)Gene
Name: RADiation sensitive
Synonyms: YNL250W
Source: SGD:S000005194
Biotype: protein coding gene
CDK2
(Homo sapiens)Gene
Name: cyclin dependent kinase 2
Synonyms: cdc2-related protein kinase, p33 protein kinase, p33(CDK2), cyclin-dependent kinase 2, cell division protein kinase 2, cell devision kinase 2, CDKN2
Source: HGNC:1771
Biotype: protein coding gene
Atr
(Mus musculus)Gene
Name: ataxia telangiectasia and Rad3 related
Synonyms: Not Available
Source: MGI:108028
Biotype: protein coding gene
PARP1
(Homo sapiens)Gene
Name: poly(ADP-ribose) polymerase 1
Synonyms: poly (ADP-ribose) polymerase 1, ADP-ribosyltransferase (NAD+, poly (ADP-ribose) polymerase), poly(ADP-ribose) polymerase, PARP, ARTD1, ADPRT 1, ADPRT1, PARP-1, NAD(+) ADP-ribosyltransferase 1, Poly-PARP, poly(ADP-ribosyl)transferase, pADPRT-1, DNA ADP-ribosyltransferase PARP1, poly [ADP-ribose] polymerase 1, ADP-ribosyltransferase NAD(+), PARS, poly (ADP-ribose) polymerase family, member 1, PPOL, ADP-ribosyltransferase diphtheria toxin-like 1, poly[ADP-ribose] synthase 1, ADPRT, poly(ADP-ribose) synthetase
Source: HGNC:270
Biotype: protein coding gene
RAD53
(Saccharomyces cerevisiae)Gene
Name: RADiation sensitive
Synonyms: MEC2, SPK1, LSD1, YPL153C
Source: SGD:S000006074
Biotype: protein coding gene
blm
(Danio rerio)Gene
Name: BLM RecQ like helicase
Synonyms: Not Available
Source: ZFIN:ZDB-GENE-070702-5
Biotype: protein coding gene
RIF1
(Homo sapiens)Gene
Name: replication timing regulatory factor 1
Synonyms: FLJ12870, RAP1 interacting factor homolog, telomere-associated protein RIF1, DKFZp781N1478, DKFZp434D1026, rap1-interacting factor 1 homolog
Source: HGNC:23207
Biotype: protein coding gene
FEN1
(Homo sapiens)Gene
Name: flap structure-specific endonuclease 1
Synonyms: flap endonuclease 1, maturation factor 1, MF1, hFEN-1, FEN-1, maturation factor-1, RAD2, DNase IV
Source: HGNC:3650
Biotype: protein coding gene
Atm
(Mus musculus)Gene
Name: ataxia telangiectasia mutated
Synonyms: RIKEN cDNA C030026E19 gene, AI256621, C030026E19Rik, expressed sequence AI256621
Source: MGI:107202
Biotype: protein coding gene