Version: 8.0.0Date: Tue Jan 28 2025
Gene Molecular Function: signaling receptor binding Molecular Function: peptidase activator activity
NLRP3
(Homo sapiens)Gene
Name: NLR family pyrin domain containing 3
Synonyms: caterpiller protein 1.1, PYRIN-containing APAF1-like protein 1, cryopyrin, NACHT, LRR and PYD domains - containing protein 3, CIAS1, deafness, autosomal dominant 34, NACHT, LRR and PYD domains-containing protein 3, cold autoinflammatory syndrome 1, FCAS, cryopyrin, NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3, AII/AVP receptor-like, nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3, FCAS1, AGTAVPRL, DFNA34, AII, CLR1.1, MWS, PYPAF1, AII/AVP, NACHT, LRR and PYD containing protein 3, NLR family, pyrin domain containing 3, FLJ95925, NALP3, C1orf7, angiotensin/vasopressin receptor AII/AVP-like, FCU, AVP, KEFH
Source: HGNC:16400
Biotype: protein coding gene
HSPD1
(Homo sapiens)Gene
Name: heat shock protein family D (Hsp60) member 1
Synonyms: HSP60, GROEL, short heat shock protein 60 Hsp60s1, heat shock 60kDa protein 1 (chaperonin), heat shock protein 60 (liver), mitochondrial matrix protein P1, CPN60, P60 lymphocyte protein, HuCHA60, HSP-60, 60 kDa heat shock protein, mitochondrial, HLD4, 60 kDa chaperonin, spastic paraplegia 13 (autosomal dominant), heat shock protein 65, HSP65, heat shock protein family D member 1, SPG13, chaperonin 60
Source: HGNC:5261
Biotype: protein coding gene
AIM2
(Homo sapiens)Gene
Name: absent in melanoma 2
Synonyms: LOC105371461, uncharacterized LOC105371461, interferon-inducible protein AIM2, PYHIN4
Source: HGNC:357
Biotype: protein coding gene
PSME4
(Homo sapiens)Gene
Name: proteasome activator subunit 4
Synonyms: MGC138374, PA200, proteasome activator 200 kDa, Blm10, hBlm10, proteasome activator PA200, FLJ21864, KIAA0077, proteasome (prosome, macropain) activator subunit 4, proteasome activator complex subunit 4, MGC142228
Source: HGNC:20635
Biotype: protein coding gene
Ctsh
(Mus musculus)Gene
Name: cathepsin H
Synonyms: Cat H, expressed sequence AL022844, AL022844
Source: MGI:107285
Biotype: protein coding gene
NLRP1
(Homo sapiens)Gene
Name: NLR family pyrin domain containing 1
Synonyms: VAMAS1, caspase recruitment domain-containing protein 7, NACHT, LRR and PYD domains-containing protein 1, systemic lupus erythematosus, vitiligo-related 1, SLEV1, AIADK, nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 1, DEFCAP, PP1044, DEFCAP-L/S, JRRP, NACHT, leucine rich repeat and PYD (pyrin domain) containing 1, CARD7, DKFZp586O1822, death effector filament-forming Ced-4-like apoptosis protein, NLR family, pyrin domain containing 1, NACHT, LRR and PYD containing protein 1, CIDED, nucleotide-binding domain and caspase recruitment domain, NAC, caspase recruitment domain protein 7, NALP1, NACHT, leucine rich repeat and PYD containing 1, MSPC, CLR17.1, KIAA0926
Source: HGNC:14374
Biotype: protein coding gene
Nlrp3
(Mus musculus)Gene
Name: NLR family, pyrin domain containing 3
Synonyms: cryopyrin, Mmig1, Pypaf1, cold autoinflammatory syndrome 1 homolog (human), NALP3, Cias1
Source: MGI:2653833
Biotype: protein coding gene
PINK1
(Homo sapiens)Gene
Name: PTEN induced kinase 1
Synonyms: FLJ27236, serine/threonine-protein kinase PINK1, mitochondrial, Parkinson disease (autosomal recessive) 6, BRPK, PTEN induced putative kinase 1, PTEN-induced putative kinase protein 1, protein kinase BRPK, PARK6
Source: HGNC:14581
Biotype: protein coding gene
CTSL
(Homo sapiens)Gene
Name: cathepsin L
Synonyms: CTSL1, procathepsin L, MEP, CATL, FLJ31037, cathepsin L1, major excreted protein
Source: HGNC:2537
Biotype: protein coding gene
MALT1
(Homo sapiens)Gene
Name: MALT1 paracaspase
Synonyms: mucosa associated lymphoid tissue lymphoma translocation gene 1, MALT1 protease, DKFZp434L132, caspase-like protein, paracaspase 1, IMD12, paracaspase-1, MALT lymphoma-associated translocation, MLT, PCASP1, mucosa-associated lymphoid tissue lymphoma translocation protein 1, MLT1, MALT-lymphoma associated translocation, paracaspase, MALT associated translocation
Source: HGNC:6819
Biotype: protein coding gene
PRE1
(Saccharomyces cerevisiae)Gene
Name: PRoteinase yscE
Synonyms: YER012W
Source: SGD:S000000814
Biotype: protein coding gene
APH1A
(Homo sapiens)Gene
Name: aph-1 homolog A, gamma-secretase subunit
Synonyms: aph-1 homolog A, gamma secretase subunit, 6530402N02Rik, APH-1, anterior pharynx defective 1 homolog A, presenilin-stabilization factor, CGI-78, APH-1A, APH1A gamma secretase subunit, gamma-secretase subunit APH-1A, aph-1alpha
Source: HGNC:29509
Biotype: protein coding gene
PSMD14
(Homo sapiens)Gene
Name: proteasome 26S subunit, non-ATPase 14
Synonyms: proteasome (prosome, macropain) 26S subunit, non-ATPase, 14, 26S proteasome non-ATPase regulatory subunit 14, 26S proteasome-associated PAD1 homolog 1, RPN11, 26S proteasome regulatory subunit rpn11, PAD1, testis tissue sperm-binding protein Li 69n, POH1
Source: HGNC:16889
Biotype: protein coding gene
CTSC
(Homo sapiens)Gene
Name: cathepsin C
Synonyms: DPP-I, DPPI, JP, dipeptidyl-peptidase I, DPP1, HMS, dipeptidyl peptidase I, juvenile periodontitis, PLS, dipeptidyl peptidase 1, CPPI, PDON1, dipeptidyl transferase, PALS, cathepsin J, JPD
Source: HGNC:2528
Biotype: protein coding gene
CARD8
(Homo sapiens)Gene
Name: caspase recruitment domain family member 8
Synonyms: CARD inhibitor of NF-kappaB-activating ligands, caspase recruitment domain-containing protein 8, TUCAN, DACAR, MGC57162, DKFZp779L0366, caspase recruitment domain family, member 8, NDPP1, CARDINAL, FLJ18119, apoptotic protein NDPP1, NDPP, KIAA0955, tumor up-regulated CARD-containing antagonist of CASP9, Dakar, FLJ18121, tumor up-regulated CARD-containing antagonist of caspase nine
Source: HGNC:17057
Biotype: protein coding gene
CASP1
(Homo sapiens)Gene
Name: caspase 1
Synonyms: caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase), interleukin 1-beta convertase, interleukin-1 beta convertase, IL1BC, ICE, interleukin 1-B converting enzyme, caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase), caspase-1 isoform alpha, P45, CASP-1, interleukin 1, beta, convertase, IL-1 beta-converting enzyme, IL-1BC, caspase-1, caspase 1, apoptosis-related cysteine peptidase, IL1B-convertase, CASP1 nirs variant 1, interleukin-1 beta-converting enzyme
Source: HGNC:1499
Biotype: protein coding gene
Vsir
(Mus musculus)Gene
Name: V-set immunoregulatory receptor
Synonyms: Dies1, VISTA, RIKEN cDNA 4632428N05 gene, PD-1H, 4632428N05Rik
Source: MGI:1921298
Biotype: protein coding gene
SVBP
(Homo sapiens)Gene
Name: small vasohibin binding protein
Synonyms: CCDC23, coiled-coil domain-containing protein 23, coiled-coil domain containing 23, coiled coil domain-containing protein 23, NEDAHM
Source: HGNC:29204
Biotype: protein coding gene
ATP2A3
(Homo sapiens)Gene
Name: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
Synonyms: SR Ca(2+)-ATPase 3, SERCA3, calcium pump 3, sarcoplasmic/endoplasmic reticulum calcium ATPase 3, ATPase, Ca++ transporting, ubiquitous, sarco/endoplasmic reticulum Ca2+ -ATPase, adenosine triphosphatase, calcium, sarco/endoplasmic reticulum Ca2+ ATPase, ATPase, Ca(2+)-transporting, ubiquitous, calcium-translocating P-type ATPase
Source: HGNC:813
Biotype: protein coding gene
CTSH
(Homo sapiens)Gene
Name: cathepsin H
Synonyms: cathepsin B3, CPSB, pro-cathepsin H, ACC5, ACC4, DKFZp686B24257, cathepsin BA, minichain, N-benzoylarginine-beta-naphthylamide hydrolase, ACC-5, MGC1519, ACC-4, aleurain
Source: HGNC:2535
Biotype: protein coding gene
APAF1
(Homo sapiens)Gene
Name: apoptotic peptidase activating factor 1
Synonyms: DKFZp781B1145, apoptotic protease activating factor 1, APAF-1, CED4, apoptotic protease-activating factor 1
Source: HGNC:576
Biotype: protein coding gene
ScsβA
(Drosophila melanogaster)Gene
Name: Succinyl-coenzyme A synthetase beta subunit, ADP-forming
Synonyms: ATP-specific SCSbeta, Skap, SkAP, CG11963, ATP-specific form of the succinyl-CoA synthetase beta subunit, SkpA Associated Protein, skpA-associated protein, A-Sbeta, succinyl CoA synthetase, FBgn0037643, skap, CGI 1963, SkpA-associated protein, skpA associated protein
Source: FB:FBgn0037643
Biotype: protein coding gene
Ctsh
(Rattus norvegicus)Gene
Name: cathepsin H
Synonyms: cathepsin B3, cathepsin BA, pro-cathepsin H
Source: RGD:2447
Biotype: protein coding gene
Svbp
(Mus musculus)Gene
Name: small vasohibin binding protein
Synonyms: 2410005K17Rik, RIKEN cDNA 2410005K17 gene, RGD1311232, AI851162, Ccdc23, expressed sequence AI851162, coiled-coil domain containing 23
Source: MGI:1916466
Biotype: protein coding gene
BCL2L13
(Homo sapiens)Gene
Name: BCL2 like 13
Synonyms: BCL-RAMBO, Bcl2-L-13, MIL1, BCL2-like 13 (apoptosis facilitator), bcl-2-like protein 13
Source: HGNC:17164
Biotype: protein coding gene
Bad
(Mus musculus)Gene
Name: BCL2-associated agonist of cell death
Synonyms: Bbc2, Bad_v1, Bad_v2, AI325008, expressed sequence AI325008
Source: MGI:1096330
Biotype: protein coding gene
Malt1
(Mus musculus)Gene
Name: MALT1 paracaspase
Synonyms: Pcasp1, RIKEN cDNA D430033E09 gene, D430033E09Rik, paracaspase
Source: MGI:2445027
Biotype: protein coding gene
Tnfrsf10b
(Mus musculus)Gene
Name: tumor necrosis factor receptor superfamily, member 10b
Synonyms: TRAIL-R2, TRICKB, DR5, Killer/Dr5, Ly98, KILLER, Trail Receptor, TRAILR2, TRICK2B, TRICK2A
Source: MGI:1341090
Biotype: protein coding gene
PUP3
(Saccharomyces cerevisiae)Gene
Name: PUtative Proteasome subunit
Synonyms: SCS32, YER094C
Source: SGD:S000000896
Biotype: protein coding gene
Nlrc4
(Mus musculus)Gene
Name: NLR family, CARD domain containing 4
Synonyms: RIKEN cDNA 9530011P19 gene, Card12, 9530011P19Rik, caspase recruitment domain family, member 12, Ipaf
Source: MGI:3036243
Biotype: protein coding gene
Svbp
(Rattus norvegicus)Gene
Name: small vasohibin binding protein
Synonyms: LOC362578, RGD1311232, Ccdc23, similar to RIKEN cDNA 2410005K17, MGC116404, coiled-coil domain-containing protein 23, coiled coil domain-containing protein 23, coiled-coil domain containing 23
Source: RGD:1311232
Biotype: protein coding gene
Nlrp3
(Rattus norvegicus)Gene
Name: NLR family, pyrin domain containing 3
Synonyms: PYRIN-containing APAF1-like protein 1, cryopyrin, cold autoinflammatory syndrome 1 homolog (human), cold autoinflammatory syndrome 1 homolog, Cias1, mast cell maturation-associated-inducible protein 1, cold autoinflammatory syndrome 1, NACHT, LRR and PYD domains-containing protein 3, cold autoinflammatory syndrome 1 protein homolog, LOC287362
Source: RGD:1308314
Biotype: protein coding gene
ced-3
(Caenorhabditis elegans)Gene
Name: CEll Death abnormality 3
Synonyms: CELE_C48D1.2, C48D1.2
Source: WB:WBGene00000417
Biotype: protein coding gene
bur
(Drosophila melanogaster)Gene
Name: burgundy
Synonyms: GMP-synthetase, l(2)10523, GMPS, Gmps, CG9242, gua2, anon-WO0118547.204, GMP synthetase, anon-WO0118547.193, P174, ES2-2, Bur, Enhancer of GMR-sina 2-2
Source: FB:FBgn0000239
Biotype: protein coding gene
Nkx3-1
(Mus musculus)Gene
Name: NK3 homeobox 1
Synonyms: NKX3A, NKX3.1, Bax, Nkx-3.1, bagpipe, Nkx3.1
Source: MGI:97352
Biotype: protein coding gene
Wdr20
(Mus musculus)Gene
Name: WD repeat domain 20
Synonyms: RIKEN cDNA 2310040A13 gene, 2310040A13Rik, Wdr20a, WD repeat domain 20A, expressed sequence AI549910, AI549910
Source: MGI:1916891
Biotype: protein coding gene
psme-3
(Caenorhabditis elegans)Gene
Name: ProteaSoME activator subunit 3
Synonyms: CELE_Y66D12A.9, Y66D12A.9
Source: WB:WBGene00013435
Biotype: protein coding gene
Pcolce
(Mus musculus)Gene
Name: procollagen C-endopeptidase enhancer protein
Synonyms: Astt-2, Astt2, astroglial cell transcript 2, PCPE
Source: MGI:105099
Biotype: protein coding gene
Rock2
(Mus musculus)Gene
Name: Rho-associated coiled-coil containing protein kinase 2
Synonyms: ROKalpha, Rock-II, B230113H15Rik, ROCK-II, Rho-kinase, Rock2m, RIKEN cDNA B230113H15 gene, ROK
Source: MGI:107926
Biotype: protein coding gene
Psme4
(Mus musculus)Gene
Name: proteasome (prosome, macropain) activator subunit 4
Synonyms: AU041366, expressed sequence AU041366, b2b1508Clo, expressed sequence AA409398, AA409398
Source: MGI:2143994
Biotype: protein coding gene
NLRP12
(Homo sapiens)Gene
Name: NLR family pyrin domain containing 12
Synonyms: PYPAF7, nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 12, monarch-1, NALP12, NACHT, LRR and PYD containing protein 12, NACHT, LRR and PYD domains-containing protein 12, RNO, regulated by nitric oxide, NLR family, pyrin domain containing 12, RNO2, FCAS2, CLR19.3, PYRIN-containing APAF1-like protein 7, PAN6, monarch 1
Source: HGNC:22938
Biotype: protein coding gene
Psenen
(Mus musculus)Gene
Name: presenilin enhancer gamma secretase subunit
Synonyms: RGD1312037, RIKEN cDNA 1700023M09 gene, Pen2, 1700023M09Rik
Source: MGI:1913590
Biotype: protein coding gene
Tifab
(Mus musculus)Gene
Name: TRAF-interacting protein with forkhead-associated domain, family member B
Synonyms: cDNA sequence BC027057, BC027057, RGD1311681, MGC:32345, MGC:37193
Source: MGI:2385852
Biotype: protein coding gene
ctsh
(Danio rerio)Gene
Name: cathepsin H
Synonyms: wu:fc44c02, zgc:85774, fc44c02
Source: ZFIN:ZDB-GENE-030131-3539
Biotype: protein coding gene
PSME2
(Homo sapiens)Gene
Name: proteasome activator subunit 2
Synonyms: protease (prosome, macropain) 28 subunit, beta, 11S regulator complex subunit beta, activator of multicatalytic protease subunit 2, proteasome activator hPA28 subunit beta, proteasome activator 28 subunit beta, PA28B, PA28beta, cell migration-inducing protein 22, REG-beta, REGbeta, proteasome activator 28-beta, proteasome activator complex subunit 2, 11S regulator complex beta subunit, proteasome (prosome, macropain) activator subunit 2 (PA28 beta), MCP activator, 31-kD subunit
Source: HGNC:9569
Biotype: protein coding gene
FGL2
(Homo sapiens)Gene
Name: fibrinogen like 2
Synonyms: fibrinogen-like 2, T49, fibroleukin, pT49, fibrinogen-like protein 2
Source: HGNC:3696
Biotype: protein coding gene
RPS27L
(Homo sapiens)Gene
Name: ribosomal protein S27 like
Synonyms: 40S ribosomal protein S27-like, ribosomal protein S27-like, ribosomal protein eS27-like, small ribosomal subunit protein eS27-like
Source: HGNC:18476
Biotype: protein coding gene
CLPX
(Homo sapiens)Gene
Name: caseinolytic mitochondrial matrix peptidase chaperone subunit X
Synonyms: ClpX caseinolytic protease X homolog, clpx caseinolytic protease x homolog (e. coli), ClpX caseinolytic peptidase X homolog, energy-dependent regulator of proteolysis, ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial, EPP2, caseinolytic mitochondrial matrix peptidase chaperone subunit
Source: HGNC:2088
Biotype: protein coding gene
Nlrp1b
(Rattus norvegicus)Gene
Name: NLR family, pyrin domain containing 1B
Synonyms: NACHT, LRR and PYD domains-containing protein 1b allele 3-like, LOC691998, similar to NACHT, leucine rich repeat and PYD containing 1, AABR07029890.1
Source: RGD:1593294
Biotype: protein coding gene
Psme3
(Mus musculus)Gene
Name: proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki)
Synonyms: AU020960, Ab2-371, pa28g, AA410043, expressed sequence AU020960, REGgamma, Ki, expressed sequence AA410043, PA28gamma
Source: MGI:1096366
Biotype: protein coding gene