Gene

cpb

Species
Drosophila melanogaster
Symbol
cpb
Name
capping protein beta
Synonyms
  • actin capping protein
  • actin capping protein beta
Biotype
protein coding gene
Automated Description
Enables protein heterodimerization activity. Involved in several processes, including barbed-end actin filament capping; oogenesis; and regulation of plasma membrane bounded cell projection assembly. Part of F-actin capping protein complex. Colocalizes with adherens junction. Is expressed in several structures, including amnioserosa; anterior-posterior subdivision of organism; embryonic/larval hemocyte; embryonic/larval midgut primordium; and gut section. Orthologous to human CAPZB (capping actin protein of muscle Z-line subunit beta).
FB Description
capping protein beta (cpb) encodes an actin-binding protein that, together with cpa, binds to the fast growing ends of actin filaments, restricting the addition or loss of actin monomers. It restricts JNK signaling, modulates Hippo signaling, maintains epithelial integrity and neuronal homeostasis, controls proliferation/apoptosis in wing imaginal discs, and promotes oogenesis.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10619
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensCAPZB9 of 9YesYes   
Mus musculusCapzb9 of 9YesYes   
Rattus norvegicusCapzb9 of 9YesYes   
Xenopus tropicaliscapzb2 of 9YesYes   
Danio reriocapzb9 of 10YesYes  
Caenorhabditis eleganscap-29 of 9YesYes   
Saccharomyces cerevisiaeCAP29 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

No paralogs for the gene.

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
abnormal cell migration
actin cytoskeleton & eye disc | somatic clone
actin filament & dorsal mesothoracic disc & pupa | somatic clone
adult abdomen | somatic clone
border follicle cell
chaeta | somatic clone
eye photoreceptor cell & nucleus | somatic clone
eye photoreceptor cell | somatic clone
eye | somatic clone
fertile | male
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
References
Rattus norvegicusCapzb
is marker fordementia
  • IEP
    Danio reriocapzb
    is implicated incleft palate
    • IC
      Showing 1 - 2 of 2 rows
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      Alleles and Variants

      Genome location
      Assembly version
      R6
      Viewer Help
      1.7050M1.7052M1.7054M1.7056M1.7058M1.7060M1.7062M1.7064M1.7066M1.7068M
      Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
      cpb6.15
      • cpb[6-15]
      • cpb[6.15]
      allele
      Yes
      cpbF19
      • cpb[F19]
      allele
      Yes
      cpb4.18
      • cpb[4.18]
      allele
      Yes
      cpb1
      • cpb[1]
      allele
      cpbunspecified
      • cpb[unspecified]
      allele
      Yes
      cpbKO
      • cpb[KO]
      allele
      cpbCR71327-KO-TG4.0
      • cpb[CR71327-KO-TG4.0]
      allele
      cpbDP00046
      • cpb[DP00046]
      allele with one associated variant
      insertion
      • 5 prime UTR variant
      cpbM143
      • cpb[M14]
      • cpb[M143]
      allele with one associated variant
      point mutation
      • stop gained
      Yes
      cpbF44
      • cpb[F44]
      allele with one associated variant
      point mutation
      • stop gained
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
      Drosophila melanogastercpb+t4.5
      Yes
      Drosophila melanogastercpbGD9299
      • UASt
      Drosophila melanogastercpbHMJ21056
      • UAS
      Drosophila melanogastercpbHMS02349
      • UAS
      Drosophila melanogastercpbJF02068
      • UAS
      Drosophila melanogastercpbL262R.UAS
      • UAS
      Drosophila melanogastercpbU6.2.dgRNA
      Drosophila melanogastercpbU6.NIG.sgRNA
      Drosophila melanogastercpbUAS.cWa
      • UAS
      Drosophila melanogastercpbUASp.mCherry
      • UASp
      Showing 1 - 10 of 12 rows
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      Models

      No data available

      Sequence Feature Viewer

      Genome location
      Assembly version
      R6
      Viewer Help
      1.7050M1.7052M1.7054M1.7056M1.7058M1.7060M1.7062M1.7064M1.7066M1.7068Mcpb-RA (cpb)cpb-RB (cpb)

      Sequence Details

      Loading...

      Expression

      Primary Sources
      Other Sources
      Must provide at least one subject
      Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

      Molecular Interactions

      58 interactor genes based on 62 annotations
      cpb molecule type
      Interactor gene
      Interactor species
      Interactor molecule type
      Detection methods
      Source
      Reference
      protein
      Act57BDrosophila melanogaster
      protein
      • experimental knowledge based
      PMID:22036573
      protein
      Ae2Drosophila melanogaster
      protein
      • two hybrid
      PMID:14605208
      protein
      AktDrosophila melanogaster
      protein
      • anti tag coimmunoprecipitation
      PMID:27626673
      protein
      Ant2Drosophila melanogaster
      protein
      • two hybrid
      PMID:14605208
      protein
      Arp2Drosophila melanogaster
      protein
      • experimental knowledge based
      PMID:22036573
      protein
      Arp3Drosophila melanogaster
      protein
      • experimental knowledge based
      PMID:22036573
      protein
      Arp10Drosophila melanogaster
      protein
      • experimental knowledge based
      PMID:22036573
      protein
      Arpc1Drosophila melanogaster
      protein
      • experimental knowledge based
      PMID:22036573
      protein
      Arpc2Drosophila melanogaster
      protein
      • experimental knowledge based
      PMID:22036573
      protein
      Arpc4Drosophila melanogaster
      protein
      • experimental knowledge based
      PMID:22036573
      Showing 1 - 10 of 55 rows
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      Genetic Interactions

      cpb role
      cpb genetic perturbation
      Interactor gene
      Interactor species
      Interactor role
      Interactor genetic perturbation
      Interaction type
      Phenotype or trait
      Source
      Reference
      suppressed gene
      chicDrosophila melanogaster
      suppressor gene
      genetic suppression
        PMID:12529431
        enhancer gene
        cindrDrosophila melanogaster
        enhanced gene
        genetic enhancement
          PMID:18362180
          enhancer gene
          CskDrosophila melanogaster
          enhanced gene
          genetic enhancement
            PMID:23831567
            enhancer gene
            NDrosophila melanogaster
            enhanced gene
            genetic enhancement
              PMID:21447553
              suppressor gene
              notDrosophila melanogaster
              suppressed gene
              genetic suppression
                PMID:33988679
                suppressor gene
                PknDrosophila melanogaster
                suppressed gene
                genetic suppression
                  PMID:25131196
                  suppressor gene
                  wtsDrosophila melanogaster
                  suppressed gene
                  genetic suppression
                    PMID:23733343
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