Gene

dhs-28

Species
Caenorhabditis elegans
Symbol
dhs-28
Name
DeHydrogenases, Short chain 28
Synonyms
  • CELE_M03A8.1
  • M03A8.1
Biotype
protein coding gene
Automated Description
Predicted to enable 3-hydroxyacyl-CoA dehydrogenase activity and enoyl-CoA hydratase activity. Involved in several processes, including ascaroside biosynthetic process; dauer entry; and pheromone biosynthetic process. Located in peroxisome. Is expressed in hypodermis and intestine. Used to study obesity. Human ortholog(s) of this gene implicated in D-bifunctional protein deficiency; Perrault syndrome; and Stiff-Person syndrome. Orthologous to human HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4).
WB Description
dhs-28 encodes an ortholog of human 17-BETA-HYDROXYSTEROID DEHYDROGENASE 4 (HSD17B4; OMIM:601860, mutated in D-bifunctional protein deficiency), which contains a C-terminal SCP-2 sterol transfer domain; the deletion allele dhs-28(ok450) is superficially wild-type.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45024
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensHSD17B44 of 9YesYes   
Mus musculusHsd17b44 of 9YesYes   
Rattus norvegicusHsd17b44 of 9YesYes   
Xenopus tropicalishsd17b46 of 9YesYes   
Danio reriohsd17b44 of 9YesYes   
Drosophila melanogasterMfe25 of 9YesYes   
Saccharomyces cerevisiaeFOX25 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
dhs-15134242262 of 8  
cror-2233641272 of 8  
F28H7.2334941242 of 8  
D1054.8432940242 of 8  
dhs-25525450332 of 8  
dhsl-4631641242 of 8  
C06E4.3731241252 of 8  
F02C12.2830941242 of 8  
let-767934235242 of 8  
F26D2.151031542222 of 8  
W03F9.91128144252 of 8  
C06E4.61227545252 of 8  
ZK829.11325646282 of 8  
dhs-111425746282 of 8  
stdh-11530537252 of 8  
dhs-41624747282 of 8  
F25D1.51724945272 of 8  
T01G6.11825144262 of 8  
dhs-231925743252 of 8  
dhs-32023348272 of 8  
ard-12122647282 of 8  
dhs-142220950302 of 8  
cror-12321050282 of 8  
maoc-12423339233 of 8  
stdh-42524540272 of 8  
dhs-192619949312 of 8  
stdh-22721243262 of 8  
dhs-272819147302 of 8  
nta-12920446252 of 8  
stdh-33020542252 of 8  

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
ascaroside biosynthesis variant
dauer pheromone production defective
developmental timing variant
fat associated bodies increased
fat content variant
larval arrest
lipid composition variant
lipid hydrolysis regulation variant
organism starvation response variant
protein subcellular localization variant
Showing 1 - 10 of 11 rows
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Disease Associations

Cases where the expected disease association was NOT found
all annotationsall disease by infectious agentbacterial infectious diseasefungal infectious diseaseparasitic infectious diseaseviral infectious diseaseall disease of anatomical entitycardiovascular system diseasecentral nervous system diseaseendocrine system diseasegastrointestinal system diseasehematopoietic system diseaseimmune system diseaseintegumentary system diseasemusculoskeletal system diseaseperipheral nervous system diseasereproductive system diseaserespiratory system diseasesensory system diseasethoracic diseaseurinary system diseaseall disease of cellular proliferationbenign neoplasmcancerpre-malignant neoplasmall genetic diseasechromosomal diseasemonogenic diseasepolygenic diseaseall other diseasedisease of mental healthdisease of metabolismphysical disordersyndrome
dhs-28 (Cel)
HSD17B4 (Hsa)
Hsd17b4 (Mmu)
Hsd17b4 (Rno)
hsd17b4 (Xtr)
Cell color indicative of annotation volume
Species
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
References
Caenorhabditis elegansdhs-28
is implicated inobesity
  • IMP
  • CEA
    Homo sapiensHSD17B4
    is implicated inD-bifunctional protein deficiency
    • IAGP
      Homo sapiensHSD17B4
      is implicated in
      • severity of
      D-bifunctional protein deficiency
      • IAGP
        Homo sapiensHSD17B4
        is implicated inPerrault syndrome
        • IAGP
          Homo sapiensHSD17B4
          is implicated inStiff-Person syndrome
          • IDA
            Rattus norvegicusHsd17b4
            is marker forhypertension
            • IEP
              Mus musculusHsd17b4
              is implicated inD-bifunctional protein deficiency
              • TAS
                Saccharomyces cerevisiaeFOX2
                is implicated inlipid metabolism disorder
                • ISS
                • IGI
                Showing 1 - 8 of 8 rows
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                Alleles and Variants

                Genome location
                Assembly version
                WBcel235
                Viewer Help
                6.8186M6.8188M6.8190M6.8192M6.8194M6.8196M6.8198M6.8200M
                Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
                Allele/Variant Symbol
                Allele Synonyms
                Category
                Variant
                Variant type
                Molecular consequence
                Has Disease Annotations
                Has Phenotype Annotations
                hj8allele
                YesYes
                hj5allele with one associated variant
                point mutation
                • missense variant
                Yes
                hj6allele with one associated variant
                point mutation
                • missense variant
                Yes
                tm2581allele with one associated variant
                deletion
                • splice acceptor variant
                Yes
                hj7allele with one associated variant
                point mutation
                • missense variant
                Yes
                NC_003284.9:g.6818886C>Tvariant
                SNP
                • missense variant
                NC_003284.9:g.6819029T>Avariant
                SNP
                • synonymous variant
                NC_003284.9:g.6818803G>Avariant
                SNP
                • missense variant
                NC_003284.9:g.6819879A>Cvariant
                SNP
                • intron variant
                NC_003284.9:g.6819918G>Avariant
                SNP
                • missense variant
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                Transgenic Alleles

                No data available

                Models

                Model name
                Experimental condition
                Associated Human Diseases
                Associated Phenotypes
                Modifier
                Source
                CLP1357WB
                CLP1361WB
                CLP1363WB
                CLP1364WB
                CLP1365WB
                CLP1422WB
                CLP1490WB
                VS8WB
                Showing 1 - 8 of 8 rows
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                Sequence Feature Viewer

                Genome location
                Assembly version
                WBcel235
                Viewer Help
                6.8186M6.8188M6.8190M6.8192M6.8194M6.8196M6.8198M6.8200MM03A8.1.1 (dhs-28)M03A8.4.1 (gei-15)

                Sequence Details

                Loading...

                Expression

                Primary Sources
                Other Sources
                Must provide at least one subject
                Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

                Molecular Interactions

                15 interactor genes based on 18 annotations
                dhs-28 molecule type
                Interactor gene
                Interactor species
                Interactor molecule type
                Detection methods
                Source
                Reference
                protein
                atx-2Caenorhabditis elegans
                protein
                • affinity chromatography technology
                PMID:27457958
                protein
                ccar-1Caenorhabditis elegans
                protein
                • affinity chromatography technology
                PMID:38126797
                protein
                dhs-28Caenorhabditis elegans
                protein
                • x ray scattering
                PMID:23313254
                protein
                dlg-1Caenorhabditis elegans
                protein
                • affinity chromatography technology
                PMID:27506200
                protein
                glh-1Caenorhabditis elegans
                protein
                • affinity chromatography technology
                PMID:31506335
                protein
                glh-1Caenorhabditis elegans
                protein
                • affinity chromatography technology
                PMID:32245789
                protein
                gras-1Caenorhabditis elegans
                protein
                • affinity chromatography technology
                PMID:36809245
                protein
                hsp-16.2Caenorhabditis elegans
                protein
                • affinity chromatography technology
                PMID:26009280
                protein
                hsp-16.2Caenorhabditis elegans
                protein
                • affinity chromatography technology
                PMID:26009280
                protein
                lin-53Caenorhabditis elegans
                protein
                • affinity chromatography technology
                PMID:31397537
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                Genetic Interactions

                dhs-28 role
                dhs-28 genetic perturbation
                Interactor gene
                Interactor species
                Interactor role
                Interactor genetic perturbation
                Interaction type
                Phenotype or trait
                Source
                Reference
                suppressor gene
                clk-1Caenorhabditis elegans
                suppressed gene
                qm30
                genetic suppression (partial)
                  PMID:22438816
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