Version: 8.0.0Date: Tue Jan 28 2025
Gene Biological Process: negative regulation of protein catabolic process
FLNA
(Homo sapiens)Gene
Name: filamin A
Synonyms: OPD, FLN-A, filamin-1, FLN1, FLN, XMVD, filamin A, alpha, XLVD, actin binding protein 280, FG syndrome 2, alpha filamin, MNS, filamin 1, DKFZp434P031, FMD, CSBS, FGS2, endothelial actin-binding protein, non-muscle filamin, OPD2, OPD1, NHBP, alpha-filamin, FLJ43642, filamin-A, ABPX, ABP-280, CVD1
Source: HGNC:3754
Biotype: protein coding gene
Shh
(Mus musculus)Gene
Name: sonic hedgehog
Synonyms: hedgehog gene 1, Dsh, Hhg1, short digits, ShhNC
Source: MGI:98297
Biotype: protein coding gene
daf-2
(Caenorhabditis elegans)Gene
Name: abnormal DAuer Formation 2
Synonyms: Y55D5A.5, CELE_Y55D5A.5
Source: WB:WBGene00000898
Biotype: protein coding gene
EGFR
(Homo sapiens)Gene
Name: epidermal growth factor receptor
Synonyms: PIG61, NNCIS, receptor tyrosine-protein kinase erbB-1, epidermal growth factor receptor tyrosine kinase domain, EGFR vIII, proto-oncogene c-ErbB-1, cell growth inhibiting protein 40, erb-b2 receptor tyrosine kinase 1, ERRP, ERBB, epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian), erythroblastic leukemia viral (v-erb-b) oncogene homolog, ERBB1, mENA, avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, cell proliferation-inducing protein 61, NISBD2, HER1
Source: HGNC:3236
Biotype: protein coding gene
Flna
(Mus musculus)Gene
Name: filamin, alpha
Synonyms: dilated pupils 2, filamin 1, filamin-1, Dilp2, actin-binding protein 280, Fln1, GENA 379, RIKEN cDNA F730004A14 gene, F730004A14Rik, ABP-280, RGD1560614
Source: MGI:95556
Biotype: protein coding gene
SNCA
(Homo sapiens)Gene
Name: synuclein alpha
Synonyms: non-A beta component of AD amyloid, PARK1, MGC110988, Parkinson disease (autosomal dominant, Lewy body) 4, synuclein, alpha (non A4 component of amyloid precursor), NACP, truncated alpha synuclein, I+/--synuclein, alpha-synuclein, isoform NACP140, synuclein, alpha, PARK4, alpha-synuclein, synuclein alpha-140, non-A4 component of amyloid, non A-beta component of AD amyloid, PD1
Source: HGNC:11138
Biotype: protein coding gene
crb
(Drosophila melanogaster)Gene
Name: crumbs
Synonyms: Crbs, l(3)07207, CT19912, 0509/20, Crumbs, CG6383, 1384/04, Crb, CRB, crumb, crumbs, far, fat rhabdomere, l(3)S058104, DmCrb, l(3)S050920, lethal (3) 07207, l(3)j1B5, fat rhabdomeres
Source: FB:FBgn0259685
Biotype: protein coding gene
IL10
(Homo sapiens)Gene
Name: interleukin 10
Synonyms: CSIF, MGC126450, MGC126451, TGIF, GVHDS, IL10A, T-cell growth inhibitory factor, cytokine synthesis inhibitory factor, interleukin-10, IL-10
Source: HGNC:5962
Biotype: protein coding gene
INS
(Homo sapiens)Gene
Name: insulin
Synonyms: IRDN, proinsulin, preproinsulin, insulin-dependent diabetes mellitus 2, PNDM4, IDDM, ILPR, insulin isoform U3B, MODY10, IDDM1, IDDM2
Source: HGNC:6081
Biotype: protein coding gene
SHH
(Homo sapiens)Gene
Name: sonic hedgehog signaling molecule
Synonyms: HLP3, HPE3, sonic hedgehog, TPT, ShhNC, sonic hedgehog homolog, HHG1, MCOPCB5, SMMCI, sonic hedgehog protein, shh unprocessed N-terminal signaling and C-terminal autoprocessing domains, TPTPS
Source: HGNC:10848
Biotype: protein coding gene
SMAD4
(Homo sapiens)Gene
Name: SMAD family member 4
Synonyms: hSMAD4, deleted in pancreatic carcinoma locus 4, MADH4, MAD homolog 4, mothers against decapentaplegic homolog 4, SMAD 4, mothers against DPP homolog 4, deletion target in pancreatic carcinoma 4, JIP, MAD, mothers against decapentaplegic homolog 4, mothers against decapentaplegic, Drosophila, homolog of, 4, smad, mothers against dpp homolog 4 (drosophila), MYHRS, DPC4, SMAD, mothers against DPP homolog 4
Source: HGNC:6770
Biotype: protein coding gene
CSNK2A1
(Homo sapiens)Gene
Name: casein kinase 2 alpha 1
Synonyms: CK II alpha 3, protein kinase CK2, CSNK2A3, CK2A1, casein kinase 2, alpha 1 polypeptide, casein kinase II subunit alpha, casein kinase II alpha 1 subunit, OCNDS, casein kinase ii, alpha 1 polypeptide, CKII, CK II alpha, Cka1, Cka2, CK2 catalytic subunit alpha, casein kinase II alpha 1 polypeptide pseudogene
Source: HGNC:2457
Biotype: protein coding gene
CTSA
(Homo sapiens)Gene
Name: cathepsin A
Synonyms: carboxypeptidase L, GSL, protective protein for beta-galactosidase (galactosialidosis), beta-galactosidase protective protein, carboxypeptidase C, lysosomal carboxypeptidase A, deamidase, beta-galactosidase 2, carboxypeptidase-L, GLB2, urinary kininase, lysosomal protective protein, NGBE, carboxypeptidase Y-like kininase, protective protein cathepsin A, PPCA, PPGB
Source: HGNC:9251
Biotype: protein coding gene
Il10
(Mus musculus)Gene
Name: interleukin 10
Synonyms: IL10X, cytokine synthesis inhibitory factor, If2a, IL-10, Il-10
Source: MGI:96537
Biotype: protein coding gene
Snca
(Mus musculus)Gene
Name: synuclein, alpha
Synonyms: alpha-Syn, alphaSYN, alpha-synuclein
Source: MGI:1277151
Biotype: protein coding gene
HSP90AB1
(Homo sapiens)Gene
Name: heat shock protein 90 alpha family class B member 1
Synonyms: heat shock protein 90kDa alpha family class B member 1, HSP 90, FLJ26984, D6S182, heat shock protein family C member 3, HSP 84, heat shock protein HSP 90-beta, HSP90 beta, HSPC2, heat shock 84 kDa, 90-kda heat shock protein beta, HSP90B, heat shock protein beta, HSPCB, HSP90-BETA, heat shock 90kD protein 1, beta, heat shock protein 90 kDa, HSP84, 90-kda heat shock protein beta HSP90 beta, heat shock protein 90kDa alpha (cytosolic), class B member 1
Source: HGNC:5258
Biotype: protein coding gene
Prkcg
(Mus musculus)Gene
Name: protein kinase C, gamma
Synonyms: PKCgamma, PKCI, Prkcc, RATPKCI, PKC, Prkc, Pkcc
Source: MGI:97597
Biotype: protein coding gene
USP7
(Homo sapiens)Gene
Name: ubiquitin specific peptidase 7
Synonyms: Chromosome 16p13.2 deletion syndrome, DEL16P13.2, ubiquitin-specific-processing protease 7, ubiquitin specific protease 7 (herpes virus-associated), HAUSP, HAFOUS, ubiquitin thioesterase 7, deubiquitinating enzyme 7, TEF1, C16DELp13.2, ubiquitin carboxyl-terminal hydrolase 7, ubiquitin specific peptidase 7 (herpes virus-associated), herpesvirus-associated ubiquitin-specific protease, Herpes virus-associated ubiquitin-specific protease
Source: HGNC:12630
Biotype: protein coding gene
CSNK2A2
(Homo sapiens)Gene
Name: casein kinase 2 alpha 2
Synonyms: FLJ43934, casein kinase II subunit alpha', CSNK2A1, CK2alpha', CK2A2, casein kinase 2 alpha', CK II alpha', casein kinase 2, alpha prime polypeptide
Source: HGNC:2459
Biotype: protein coding gene
FURIN
(Homo sapiens)Gene
Name: furin, paired basic amino acid cleaving enzyme
Synonyms: paired basic amino acid residue-cleaving enzyme, FUR, dibasic processing enzyme, furin (paired basic amino acid cleaving enzyme), SPC1, PCSK3, FURIN/ADAMTS1 fusion, subtilisin-like proprotein convertase 1, dibasic-processing enzyme, PACE, furin, membrane associated receptor protein, proprotein convertase subtilisin/kexin 3, FES upstream region, proprotein convertase subtilisin/kexin type 3
Source: HGNC:8568
Biotype: protein coding gene
CSNK2B
(Homo sapiens)Gene
Name: casein kinase 2 beta
Synonyms: casein kinase II b subunit splicing isoform 132, phosvitin, casein kinase 2, beta polypeptide, Casein kinase II beta subunit, alternative name: G5a, phosvitin, casein kinase II b subunit splicing isoform 806, POBINDS, CSNK2B-LY6G5B-1072, MGC138222, casein kinase II subunit beta, MGC138224, CK2N, chimera CSNK2B-LY6G5B splicing isoform 532, chimera CSNK2B-LY6G5B splicing isoform 560, casein kinase II b subunit splicing isoform 660, CSNK2B-LY6G5B-532, casein kinase II b subunit splicing isoform 247, chimera CSNK2B-LY6G5B splicing isoform 1072, chimera CSNK2B-LY6G5B splicing isoform 562, CK2B, CSNK2B-LY6G5B-1103, CK II beta, G5A, Ckb1, Ckb2, CSNK2B-LY6G5B-562, CSNK2B-LY6G5B-560, chimera CSNK2B-LY6G5B splicing isoform 1103, CSK2B, casein kinase II b subunit splicing isoform 318
Source: HGNC:2460
Biotype: protein coding gene
Nrg1
(Mus musculus)Gene
Name: neuregulin 1
Synonyms: RIKEN cDNA D230005F13 gene, HRGalpha, GGF, HGL, Hgl, GGFII, NDF, 6030402G23Rik, heregulin, ARIA, SMDF, RIKEN cDNA 6030402G23 gene, D230005F13Rik, HRG
Source: MGI:96083
Biotype: protein coding gene
Fyn
(Mus musculus)Gene
Name: Fyn proto-oncogene
Synonyms: expressed sequence AW552119, AW552119, AI448320, Src Kinase p59, expressed sequence AI448320
Source: MGI:95602
Biotype: protein coding gene
NOS2
(Homo sapiens)Gene
Name: nitric oxide synthase 2
Synonyms: nitric oxide synthase 2, inducible, HEP-NOS, inducible NOS, INOS, NOS type II, nitric oxide synthase, inducible, inducible NO synthase, NOS, type II, NOS2A, NOS, hepatocyte NOS, nitric oxide synthase, macrophage, nitric oxide synthase 2A (inducible, hepatocytes), peptidyl-cysteine S-nitrosylase NOS2
Source: HGNC:7873
Biotype: protein coding gene
PARK7
(Homo sapiens)Gene
Name: Parkinsonism associated deglycase
Synonyms: Parkinson disease (autosomal recessive, early onset) 7, protein/nucleic acid deglycase DJ-1, FLJ27376, Parkinson disease protein 7, DJ1, DJ-1, oncogene DJ1, HEL-S-67p, maillard deglycase, GATD2, FLJ34360, epididymis secretory sperm binding protein Li 67p, parkinson protein 7, FLJ92274
Source: HGNC:16369
Biotype: protein coding gene
PHB1
(Homo sapiens)Gene
Name: prohibitin 1
Synonyms: BAP32, HEL-S-54e, epididymis luminal protein 215, PHB, HEL-215, epididymis secretory sperm binding protein Li 54e, prohibitin
Source: HGNC:8912
Biotype: protein coding gene
HMGCR
(Homo sapiens)Gene
Name: 3-hydroxy-3-methylglutaryl-CoA reductase
Synonyms: hydroxymethylglutaryl-CoA reductase, 3-hydroxy-3-methylglutaryl-Coenzyme A reductase, LDLCQ3, HMG-CoA reductase, 3-hydroxy-3-methylglutaryl CoA reductase (NADPH), LGMDR28, MYPLG
Source: HGNC:5006
Biotype: protein coding gene
VPS35
(Homo sapiens)Gene
Name: VPS35 retromer complex component
Synonyms: vesicle protein sorting 35, DKFZp434P1672, hVPS35, FLJ10752, vacuolar protein sorting 35 homolog, vacuolar protein sorting-associated protein 35, PARK17, VPS35, retromer complex component, FLJ13588, DKFZp434E1211, FLJ20388, MEM3, maternal-embryonic 3
Source: HGNC:13487
Biotype: protein coding gene
USP14
(Homo sapiens)Gene
Name: ubiquitin specific peptidase 14
Synonyms: TGT, ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase), deubiquitinating enzyme 14, ubiquitin thiolesterase 14, Ubp6, ubiquitin thioesterase 14, ubiquitin-specific-processing protease 14, ubiquitin carboxyl-terminal hydrolase 14, tRNA-guanine transglycosylase, 60-kD subunit, ubiquitin-specific processing protease 14, ubiquitin specific protease 14 (tRNA-guanine transglycosylase)
Source: HGNC:12612
Biotype: protein coding gene
Gipc1
(Mus musculus)Gene
Name: GIPC PDZ domain containing family, member 1
Synonyms: Rgs19, neurophilin1-IP, TIP-2, Gipc, TaxIP2, Semcap1, Glut1CIP, Rgs19ip1, semaF cytoplasmic domain associated protein 1, regulator of G-protein signaling 19 interacting protein 1, synectin
Source: MGI:1926252
Biotype: protein coding gene
CYP51A1
(Homo sapiens)Gene
Name: cytochrome P450 family 51 subfamily A member 1
Synonyms: cytochrome P450 51A1, CYPL1, lanosterol 14-alpha-demethylase, cytochrome P450-14DM, cytochrome P450LI, lanosterol 14-alpha demethylase, sterol 14-alpha demethylase, CYPLI, CYP51, LDM, CP51, cytochrome P450, family 51, subfamily A, polypeptide 1, cytochrome P45014DM, cytochrome P450, 51 (lanosterol 14-alpha-demethylase), P450-14DM, P450L1
Source: HGNC:2649
Biotype: protein coding gene
RELA
(Homo sapiens)Gene
Name: RELA proto-oncogene, NF-kB subunit
Synonyms: MGC131774, CMCU, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, NFKB3, nuclear factor NF-kappa-B p65 subunit, AIF3BL3, v-rel avian reticuloendotheliosis viral oncogene homolog A, NF-kappa-B p65delta3, p65, v-rel reticuloendotheliosis viral oncogene homolog A, NF-kappa-B transcription factor p65, v-rel avian reticuloendotheliosis viral oncogene homolog A (nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 (p65)), v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65, transcription factor p65
Source: HGNC:9955
Biotype: protein coding gene
Flna
(Rattus norvegicus)Gene
Name: filamin A
Synonyms: filamin, alpha, filamin-A, similar to Filamin A (Alpha-filamin) (Filamin 1) (Endothelial actin-binding protein) (Actin-binding protein 280) (ABP-280) (Nonmuscle filamin), Endothelial actin-binding protein 280), LOC293860, filamin A, alpha, similar to Filamin A (Alpha-filamin, Endothelial actin-binding protein 280), actin binding protein 280, RGD1560614
Source: RGD:1560614
Biotype: protein coding gene
Nos2
(Mus musculus)Gene
Name: nitric oxide synthase 2, inducible
Synonyms: NOS-II, Nos-2, iNos, iNOS, nitric oxide synthase-2 (brain), Nos2a
Source: MGI:97361
Biotype: protein coding gene
Ins2
(Mus musculus)Gene
Name: insulin II
Synonyms: maturity onset diabetes of the young, maturity onset diabetes of the young 4, Mody, CP-II, InsII, expressed sequence AA986540, Ins-2, Mody4, AA986540
Source: MGI:96573
Biotype: protein coding gene
Egfr
(Mus musculus)Gene
Name: epidermal growth factor receptor
Synonyms: ErbB-1, waved 2, wa2, Wa5, Errp, Erbb, AI552599, 9030024J15Rik, Errb1, ERBB1, wa-2, waved 5, avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian erythroblastosis oncogene B, RIKEN cDNA 9030024J15 gene, expressed sequence AI552599
Source: MGI:95294
Biotype: protein coding gene
Hsp90ab1
(Rattus norvegicus)Gene
Name: heat shock protein 90 alpha family class B member 1
Synonyms: heat shock protein 90kDa alpha family class B member 1, HSP 84, heat shock protein HSP 90-beta, heat shock protein 90 alpha (cytosolic), class B member 1, Hspcb, HSPC2, heat shock 84 kDa, MGC94263, heat shock 90kDa protein 1, beta, HSP90B, HSP90-BETA, HSP84, heat shock protein 90kDa alpha (cytosolic), class B member 1
Source: RGD:1303075
Biotype: protein coding gene
Hmgcr
(Rattus norvegicus)Gene
Name: 3-hydroxy-3-methylglutaryl-CoA reductase
Synonyms: HMG-CoA reductase, 3H3M, 3-hydroxy-3-methylglutaryl-coenzyme A reductase
Source: RGD:2803
Biotype: protein coding gene
Smad4
(Rattus norvegicus)Gene
Name: SMAD family member 4
Synonyms: MAD (mothers against decapentaplegic Drosophila) homolog 4, Madh4, MAD homolog 4, MAD homolog 4 (Drosophila), MAD (mothers against decapentaplegic, Drosophila) homolog 4, mothers against decapentaplegic homolog 4, SMAD 4, mothers against DPP homolog 4
Source: RGD:3033
Biotype: protein coding gene
Smad3
(Mus musculus)Gene
Name: SMAD family member 3
Synonyms: mad3, Madh3, AU022421, expressed sequence AU022421, Smad 3
Source: MGI:1201674
Biotype: protein coding gene
CDK2
(Homo sapiens)Gene
Name: cyclin dependent kinase 2
Synonyms: cdc2-related protein kinase, p33 protein kinase, p33(CDK2), cyclin-dependent kinase 2, cell division protein kinase 2, cell devision kinase 2, CDKN2
Source: HGNC:1771
Biotype: protein coding gene
FYN
(Homo sapiens)Gene
Name: FYN proto-oncogene, Src family tyrosine kinase
Synonyms: p59-FYN, protein-tyrosine kinase fyn, proto-oncogene c-Fyn, c-syn protooncogene, FYN oncogene related to SRC, FGR, YES, tyrosine kinase p59fyn(T), SYN, tyrosine-protein kinase Fyn, src/yes-related novel, SLK, OKT3-induced calcium influx regulator, proto-oncogene Syn, MGC45350, proto-oncogene tyrosine-protein kinase fyn, src-like kinase
Source: HGNC:4037
Biotype: protein coding gene
IRAK3
(Homo sapiens)Gene
Name: interleukin 1 receptor associated kinase 3
Synonyms: IRAK-M, IRAKM, interleukin-1 receptor-associated kinase 3, ASRT5, FLJ13601, inactive IL-1 receptor-associated kinase 3, IL-1 receptor-associated kinase M
Source: HGNC:17020
Biotype: protein coding gene
Park7
(Rattus norvegicus)Gene
Name: Parkinsonism associated deglycase
Synonyms: CAP1, Parkinson disease (autosomal recessive, early onset) 7, protein/nucleic acid deglycase DJ-1, parkinson protein 7, parkinson disease protein 7 homolog, fertility protein SP22, Dj1, DJ-1, SP22, contraception-associated protein 1, maillard deglycase
Source: RGD:621808
Biotype: protein coding gene
Ophn1
(Mus musculus)Gene
Name: oligophrenin 1
Synonyms: Opn1, Wtgr, wavy tiger, C130037N19Rik, RIKEN cDNA C130037N19 gene
Source: MGI:2151070
Biotype: protein coding gene
Mycbp2
(Mus musculus)Gene
Name: MYC binding protein 2, E3 ubiquitin protein ligase
Synonyms: AU023734, expressed sequence AW107953, expressed sequence R75243, AW546647, C130061D10Rik, expressed sequence AW546647, R75243, Phr1, RIKEN cDNA C130061D10 gene, AW107953, expressed sequence AU023734, pam, highwire, rpm 1, Pam
Source: MGI:2179432
Biotype: protein coding gene
Hmgcr
(Mus musculus)Gene
Name: 3-hydroxy-3-methylglutaryl-Coenzyme A reductase
Synonyms: Red, 3H3M, 3-hydroxy-3-methylglutaryl-CoA reductase, HMG-CoAR
Source: MGI:96159
Biotype: protein coding gene
OGT
(Homo sapiens)Gene
Name: O-linked N-acetylglucosamine (GlcNAc) transferase
Synonyms: O-linked N-acetylglucosamine transferase 110 kDa subunit, o linked n-acetylglucosamine transferase, MGC22921, FLJ23071, OGT1, O-GlcNAc transferase p110 subunit, O-GlcNAc transferase subunit p110, XLID106, HINCUT-1, O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase), MRX106, UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, uridinediphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyl transferase, O-GLCNAC, HRNT1, UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase
Source: HGNC:8127
Biotype: protein coding gene
MDM4
(Homo sapiens)Gene
Name: MDM4 regulator of p53
Synonyms: MRP1, double minute 4, human homolog of, MDM4, p53 regulator, HDMX, MDMX, mdm2-like p53-binding protein, MDM4 protein variant G, p53-binding protein Mdm4, Mdm4 p53 binding protein homolog, double minute 4 protein, Mdm4, transformed 3T3 cell double minute 4, p53 binding protein, DKFZp781B1423, double minute 4 homolog, BMFS6, MDM4-related protein 1, MDM4 protein variant Y, MGC132766
Source: HGNC:6974
Biotype: protein coding gene
Park7
(Mus musculus)Gene
Name: Parkinson disease (autosomal recessive, early onset) 7
Synonyms: CAP1, DJ-1, Dj1, SP22
Source: MGI:2135637
Biotype: protein coding gene