Version: 8.0.0Date: Tue Jan 28 2025
Gene Cellular Component: clathrin-coated vesicle
EGFR
(Homo sapiens)Gene
Name: epidermal growth factor receptor
Synonyms: PIG61, NNCIS, receptor tyrosine-protein kinase erbB-1, epidermal growth factor receptor tyrosine kinase domain, EGFR vIII, proto-oncogene c-ErbB-1, cell growth inhibiting protein 40, erb-b2 receptor tyrosine kinase 1, ERRP, ERBB, epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian), erythroblastic leukemia viral (v-erb-b) oncogene homolog, ERBB1, mENA, avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, cell proliferation-inducing protein 61, NISBD2, HER1
Source: HGNC:3236
Biotype: protein coding gene
APOE
(Homo sapiens)Gene
Name: apolipoprotein E
Synonyms: LDLCQ5, LPG, apolipoprotein E3, apo-E, ApoE4, MGC1571, Alzheimer disease 2 (APOE*E4-associated, late onset), AD2
Source: HGNC:613
Biotype: protein coding gene
CFTR
(Homo sapiens)Gene
Name: CF transmembrane conductance regulator
Synonyms: CF, ABCC7, cystic fibrosis transmembrane conductance regulator, atp-binding cassette (sub-family c, member 7), MRP7, CFTR/MRP, cAMP-dependent chloride channel, ATP-binding cassette transporter sub-family C member 7, dJ760C5.1, ATP-binding cassette sub-family C member 7, ABC35, cystic fibrosis transmembrane conductance regulator, TNR-CFTR, cystic fibrosis transmembrane conductance regulating, channel conductance-controlling ATPase, cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
Source: HGNC:1884
Biotype: protein coding gene
Htt
(Mus musculus)Gene
Name: huntingtin
Synonyms: C430023I11Rik, Huntington disease (human), expressed sequence AI256365, Huntington disease gene homolog, RIKEN cDNA C430023I11 gene, htt, Hd, HD, IT15, Hdh, AI256365
Source: MGI:96067
Biotype: protein coding gene
HLA-DRB1
(Homo sapiens)Gene
Name: major histocompatibility complex, class II, DR beta 1
Synonyms: MHC class II HLA-DRw10-beta, HLA-DRB1*, leucocyte antigen DRB1, DW2.2/DR2.2, FLJ76359, HLA-DR-beta 1, leucocyte antigen DR beta 1 chain, MHC class II antigen, major histocompatibility complex, class II, DR beta 1 precursor, DRw8, SS1, DR16, DR-8, MHC class II HLA-DR beta 1 chain, lymphocyte antigen DRB1, DRB1, DR-16, HLA class II histocompatibility antigen, DR-1 beta chain, DR1, MHC class II antigen HLA-DR13, DR5, FLJ75017, HLA class II antigen beta chain, DR8, DRw11, DRw10, MHC class II HLA-DR-beta cell surface glycoprotein, human leucocyte antigen DRB1, HLA-DR1B, HLA-DRB
Source: HGNC:4948
Biotype: protein coding gene
CCC2
(Saccharomyces cerevisiae)Gene
Name: Cross-Complements Ca(2+) phenotype of csg1
Synonyms: YDR270W
Source: SGD:S000002678
Biotype: protein coding gene
HLA-DQB1
(Homo sapiens)Gene
Name: major histocompatibility complex, class II, DQ beta 1
Synonyms: MHC class2 antigen, CELIAC1, IDDM1, HLA class II histocompatibility antigen, DQ beta 1 chain, MHC class II DQ beta chain, MHC class II antigen DQB1, MHC class II antigen HLA-DQ-beta-1, MHC DQ beta, lymphocyte antigen, HLA class II antigen, MHC class II HLA-DQ beta glycoprotein, major histocompatibility complex class II beta, HLA-DRB1, HLA-DQB
Source: HGNC:4944
Biotype: protein coding gene
ATP7A
(Homo sapiens)Gene
Name: ATPase copper transporting alpha
Synonyms: ATPase, Cu++ transporting, alpha polypeptide (Menkes syndrome), DSMAX, copper pump 1, Cu++-transporting P-type ATPase, Menkes disease-associated protein, SMAX3, FLJ17790, copper-transporting ATPase 1, MNK, ATPase, Cu++ transporting, alpha polypeptide, MK, HMNX
Source: HGNC:869
Biotype: protein coding gene
Lyz2
(Mus musculus)Gene
Name: lysozyme 2
Synonyms: Lyz1, Lyzs, Lzp, Lysm, lysozyme, Lys, M lysozyme structural 1, Lyz, AI326280, Lysz, Lzm-s1, expressed sequence AI326280, Lzm
Source: MGI:96897
Biotype: protein coding gene
AP2M1
(Homo sapiens)Gene
Name: adaptor related protein complex 2 subunit mu 1
Synonyms: clathrin coat-associated protein AP50, adaptor related protein complex 2 mu 1 subunit, adaptor-related protein complex 2 subunit mu, adapter-related protein complex 2 subunit mu, clathrin coat assembly protein AP50, adapter-related protein complex 2 mu subunit, adaptor-related protein complex 2, mu 1 subunit, adaptor related protein complex 2, mu 1 subunit, mu2, clathrin-associated/assembly/adaptor protein, medium 1, AP50, clathrin adaptor complex AP2, mu subunit, adaptor protein complex AP-2 subunit mu, plasma membrane adaptor AP-2 50 kDa protein, MRD60, AP-2 complex subunit mu, AP-2 mu 2 chain, clathrin assembly protein complex 2 mu medium chain, adaptin-mu2, AP-2 mu chain, clathrin assembly protein complex 2 medium chain, clathrin coat adaptor protein AP50, plasma membrane adaptor AP-2 50kDA protein, HA2 50 kDA subunit, CLAPM1
Source: HGNC:564
Biotype: protein coding gene
Arc
(Mus musculus)Gene
Name: activity regulated cytoskeletal-associated protein
Synonyms: arg 3.1, expressed sequence C86064, rg3.1, Arc3.1, C86064
Source: MGI:88067
Biotype: protein coding gene
HSPA8
(Homo sapiens)Gene
Name: heat shock protein family A (Hsp70) member 8
Synonyms: MGC131511, heat shock cognate protein, 71-kDa, epididymis luminal protein 33, heat shock 70kDa protein 8, HSPA10, lipopolysaccharide-associated protein 1, heat shock protein 8, heat shock cognate 71 kDa protein, N-myristoyltransferase inhibitor protein 71, LAP-1, MGC29929, heat shock 70kD protein 8, HSP73, LPS-associated protein 1, HSP71, constitutive heat shock protein 70, NIP71, heat shock protein family A member 8, HEL-S-72p, epididymis secretory sperm binding protein Li 72p, HSC54, heat shock 70kd protein 10, HSC70, HSC71, HEL-33, LAP1, heat shock cognate protein 54
Source: HGNC:5241
Biotype: protein coding gene
FURIN
(Homo sapiens)Gene
Name: furin, paired basic amino acid cleaving enzyme
Synonyms: paired basic amino acid residue-cleaving enzyme, FUR, dibasic processing enzyme, furin (paired basic amino acid cleaving enzyme), SPC1, PCSK3, FURIN/ADAMTS1 fusion, subtilisin-like proprotein convertase 1, dibasic-processing enzyme, PACE, furin, membrane associated receptor protein, proprotein convertase subtilisin/kexin 3, FES upstream region, proprotein convertase subtilisin/kexin type 3
Source: HGNC:8568
Biotype: protein coding gene
LDLR
(Homo sapiens)Gene
Name: low density lipoprotein receptor
Synonyms: FHC, LDLCQ2, FH, low-density lipoprotein receptor, low-density lipoprotein receptor class A domain-containing protein 3, FHCL1, LDL receptor
Source: HGNC:6547
Biotype: protein coding gene
Rab27a
(Mus musculus)Gene
Name: RAB27A, member RAS oncogene family
Synonyms: 4933437C11Rik, ashen, RIKEN cDNA 2210402C08 gene, ash, 2410003M20Rik, RIKEN cDNA 4933437C11 gene, ram, 2210402C08Rik, RIKEN cDNA 2410003M20 gene
Source: MGI:1861441
Biotype: protein coding gene
Dnm1
(Mus musculus)Gene
Name: dynamin 1
Synonyms: fitful, Dnm, expressed sequence AI838169, AI838169, Ftfl
Source: MGI:107384
Biotype: protein coding gene
Dnajc6
(Mus musculus)Gene
Name: DnaJ heat shock protein family (Hsp40) member C6
Synonyms: auxilin, 2810027M23Rik, RIKEN cDNA 2810027M23 gene, mKIAA0473
Source: MGI:1919935
Biotype: protein coding gene
Scamp1
(Mus musculus)Gene
Name: secretory carrier membrane protein 1
Synonyms: 4930505M11Rik, AW122395, AI415563, expressed sequence AI415563, RIKEN cDNA 4930505M11 gene, expressed sequence AW122395
Source: MGI:1349480
Biotype: protein coding gene
HLA-DQA1
(Homo sapiens)Gene
Name: major histocompatibility complex, class II, DQ alpha 1
Synonyms: CELIAC1, leukocyte antigen alpha chain, HLA-DCA, MHC class II surface glycoprotein, HLA class II histocompatibility antigen DQ alpha chain, FLJ27088, MHC class II HLA-D alpha glycoprotein, MHC class II antigen, HLA class II histocompatibility antigen, DQ alpha 1 chain, MHC class II antigen DQA1, GSE, MHC class II HLA-DQ-alpha-1, MHC class II DQA1, FLJ27328, MHC class II DQ alpha chain, HLA-DQA, truncated MHC class II antigen, HLA class II histocompatibility antigen, DQ(W3) alpha chain, CD, leucocyte antigen DQA1, HLA-DQA1*, MHC HLA-DQ alpha, MGC149527, DQ-A1, DC-alpha, DC-1 alpha chain, DQA1, HLA-DQB1
Source: HGNC:4942
Biotype: protein coding gene
ATP6V0C
(Homo sapiens)Gene
Name: ATPase H+ transporting V0 subunit c
Synonyms: Vma3, V-type proton ATPase 16 kDa proteolipid subunit, VPPC, ATP6L, V-type proton ATPase 16 kDa proteolipid subunit c, vacuolar H+ ATPase proton channel subunit, vacuolar ATP synthase 16 kDa proteolipid subunit, VATL, ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c, EPEO3, vacuolar proton pump 16 kDa proteolipid subunit, ATP6C, ATPL, vacuolar proton pump 16 kDa proteolipid subunit c, V-ATPase subunit c, V-ATPase 16 kDa proteolipid subunit, vacuolar proton pump, 16 kDa subunit, H(+)-transporting two-sector ATPase, 16 kDa subunit, V-ATPase 16 kDa proteolipid subunit c
Source: HGNC:855
Biotype: protein coding gene
Aak1
(Mus musculus)Gene
Name: AP2 associated kinase 1
Synonyms: DNA segment, Chr 6, ERATO Doi 245, expressed, cDNA sequence BC028270, BC028270, AU067724, AU067726, R75501, expressed sequence C79663, 5530400K14Rik, MGC:40785, D6Ertd245e, expressed sequence R75501, RIKEN cDNA 5530400K14 gene, mKIAA1048, C79663, RGD1563580, expressed sequence AU067726, expressed sequence AU067724
Source: MGI:1098687
Biotype: protein coding gene
Adcy8
(Mus musculus)Gene
Name: adenylate cyclase 8
Synonyms: expressed sequence AW060868, AW060868, AC8, Ac8
Source: MGI:1341110
Biotype: protein coding gene
CTLA4
(Homo sapiens)Gene
Name: cytotoxic T-lymphocyte associated protein 4
Synonyms: cytotoxic T-lymphocyte protein 4, CD, CD152, CELIAC3, cytotoxic T-lymphocyte antigen 4, CD152 isoform, cytotoxic T-lymphocyte-associated serine esterase-4, cd152 antigen, cytotoxic T lymphocyte associated antigen 4 short spliced form, ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4, celiac disease 3, ALPS5, cytotoxic T-lymphocyte-associated protein 4, IDDM12, GSE, CTLA-4, GRD4, ICOS, gluten-sensitive enteropathy, cytotoxic T-lymphocyte-associated antigen 4, insulin-dependent diabetes mellitus 12
Source: HGNC:2505
Biotype: protein coding gene
ADAM10
(Homo sapiens)Gene
Name: ADAM metallopeptidase domain 10
Synonyms: ADAM 10, HsT18717, a disintegrin and metalloproteinase domain 10, kuzbanian protein homolog, mammalian disintegrin-metalloprotease, kuz, disintegrin and metalloproteinase domain-containing protein 10, AD18, a disintegrin and metalloprotease domain 10, CDw156, CD156c, AD10, RAK, MADM
Source: HGNC:188
Biotype: protein coding gene
Ctla4
(Mus musculus)Gene
Name: cytotoxic T-lymphocyte-associated protein 4
Synonyms: Cd152, Ctla-4, CD152 antigen, Ly-56, CTLA-4, cytotoxic T lymphocyte-associated protein 4, sCTLA4
Source: MGI:88556
Biotype: protein coding gene
Myo1e
(Mus musculus)Gene
Name: myosin IE
Synonyms: expressed sequence AA407778, 9130023P14Rik, AA407778, 2310020N23Rik, RIKEN cDNA 9130023P14 gene, Myr3, MYR5, RIKEN cDNA 2310020N23 gene
Source: MGI:106621
Biotype: protein coding gene
CERT1
(Homo sapiens)Gene
Name: ceramide transporter 1
Synonyms: ceramide transporter, MRD34, STARD11, ceramide transfer protein, StAR-related lipid transfer (START) domain containing 11, START domain containing 11, Goodpasture antigen-binding protein, COL4A3BP, START domain-containing protein 11, hCERT, GPBP, CERTL, FLJ20597, CERT, stAR-related lipid transfer protein 11, collagen type IV alpha-3-binding protein, lipid-transfer protein CERTL
Source: HGNC:2205
Biotype: protein coding gene
RAB5A
(Homo sapiens)Gene
Name: RAB5A, member RAS oncogene family
Synonyms: RAB5, RAS-associated protein RAB5A, ras-related protein Rab-5A
Source: HGNC:9783
Biotype: protein coding gene
ADRB2
(Homo sapiens)Gene
Name: adrenoceptor beta 2
Synonyms: beta-2 adrenoceptor, BETA2AR, adrenergic receptor, beta 2, ADRBR, beta-2 adrenergic receptor, BAR, adrenoceptor beta 2, surface, catecholamine receptor, ADRB2R, adrenoceptor beta 2 surface, beta-2 adrenoreceptor, adrenergic, beta-2-, receptor, surface, ARB2, B2AR
Source: HGNC:286
Biotype: protein coding gene
AAK1
(Homo sapiens)Gene
Name: AP2 associated kinase 1
Synonyms: RP11-427H3.3, AP2-associated protein kinase 1, FLJ45252, hypothetical LOC388957, MGC164568, alternative protein AAK1, MGC138170, LOC112268437, DKFZp686K16132, FLJ31060, MGC164570, DKFZp686F03202, KIAA1048, FLJ42882, FLJ23712, adaptor-associated kinase 1, FLJ25931, uncharacterized protein FLJ45252
Source: HGNC:19679
Biotype: protein coding gene
Dab2
(Mus musculus)Gene
Name: disabled 2, mitogen-responsive phosphoprotein
Synonyms: RIKEN cDNA D630005B22 gene, AI957090, AA960054, p96, Doc-2, D630005B22Rik, expressed sequence AI957090, expressed sequence AA960054, D15Wsu122e, Doc2, 5730435J12Rik, RIKEN cDNA 5730435J12 gene, DNA segment, Chr 15, Wayne State University 122, expressed
Source: MGI:109175
Biotype: protein coding gene
Dnajc5
(Mus musculus)Gene
Name: DnaJ heat shock protein family (Hsp40) member C5
Synonyms: Csp, expressed sequence AU018536, AU018536, RIKEN cDNA 2610314I24 gene, 2610314I24Rik, cysteine string protein
Source: MGI:892995
Biotype: protein coding gene
TF
(Homo sapiens)Gene
Name: transferrin
Synonyms: PRO1557, HEL-S-71p, serotransferrin, siderophilin, PRO2086, epididymis secretory sperm binding protein Li 71p, TFQTL1, beta-1 metal-binding globulin, DKFZp781D0156
Source: HGNC:11740
Biotype: protein coding gene
Dnm2
(Mus musculus)Gene
Name: dynamin 2
Synonyms: DYIIAAB, Mutant line 2159, b2b2159Clo, Dyn2
Source: MGI:109547
Biotype: protein coding gene
Lrp1
(Mus musculus)Gene
Name: low density lipoprotein receptor-related protein 1
Synonyms: Mutant line 1554, b2b1554Clo, alpha-2-macroglobulin receptor, AI316852, CD91, expressed sequence AI316852, A2mr, LRP-1
Source: MGI:96828
Biotype: protein coding gene
SFTPA2
(Homo sapiens)Gene
Name: surfactant protein A2
Synonyms: SP-2A gamma, 35 kDa pulmonary surfactant-associated protein, FLJ51953, MGC189714, surfactant, pulmonary-associated protein A2A, SPA2, SP-2A, SP-A2 delta, surfactant protein A2 variant ABD 1A5, alveolar proteinosis protein, surfactant protein A2 variant ABD' 1A2, surfactant protein A2 variant ABD' 1A3, surfactant protein A2 variant ABD' 1A0, surfactant protein A2 variant ABD' 1A1, surfactant protein A2 variant ABD 1A0, PSPA, SPAII, FLJ93678, surfactant protein A2 variant ABD 1A3, surfactant protein A2 variant ABD 1A2, SP-A2 alpha, PSAP, surfactant protein A2 variant ABD 1A1, MGC133169, FLJ50594, collectin 5, MGC133366, COLEC5, FLJ50597, surfactant protein A2 variant ABD' 1A, SP-2A beta, PSP-A, SFTP1, surfactant protein A2 variant ABD' 1A5, ILD2, FLJ79091, collectin-5, SP-A, pulmonary surfactant-associated protein A2, surfactant protein A2 variant ABD 1A, MGC189761, SFTPA2B
Source: HGNC:10799
Biotype: protein coding gene
Vwf
(Mus musculus)Gene
Name: Von Willebrand factor
Synonyms: 6820430P06Rik, RIKEN cDNA B130011O06 gene, B130011O06Rik, RIKEN cDNA 6820430P06 gene, expressed sequence AI551257, AI551257
Source: MGI:98941
Biotype: protein coding gene
Snap91
(Rattus norvegicus)Gene
Name: synaptosome associated protein 91
Synonyms: synaptosomal-associated protein, 91kDa homolog (mouse), synaptosomal-associated protein, 91kDa homolog, AP3, 91 kDa synaptosomal-associated protein, synaptosomal-associated protein 91 kDa, clathrin coat assembly protein AP180, synaptosomal-associated protein, 91 kDa, synaptosomal-associated protein 91, clathrin assembly protein 3, Ap180, assembly protein 180 (AP180), clathrin coat-associated protein AP180
Source: RGD:69276
Biotype: protein coding gene
Ap1g1
(Rattus norvegicus)Gene
Name: adaptor related protein complex 1 subunit gamma 1
Synonyms: adaptor-related protein complex 1, gamma 1 subunit, adaptor protein complex AP-1 gamma 1 subunit, adaptor protein complex AP-1, gamma 1 subunit, AP-1 complex subunit gamma-1
Source: RGD:619785
Biotype: protein coding gene
Lyz1
(Mus musculus)Gene
Name: lysozyme 1
Synonyms: Lzp-s, Lysz, Lyz2, lysozyme, P lysozyme structural, renal amyloidosis, Lyz
Source: MGI:96902
Biotype: protein coding gene
Atp7a
(Mus musculus)Gene
Name: ATPase, copper transporting, alpha polypeptide
Synonyms: br, Mo, Menkes protein, mottled, Blo, blotchy, Mnk, MNK
Source: MGI:99400
Biotype: protein coding gene
SLC2A8
(Homo sapiens)Gene
Name: solute carrier family 2 member 8
Synonyms: GLUT-8, GLUTX1, glucose transporter X1, GLUT8, solute carrier family 2, facilitated glucose transporter member 8, glucose transporter type X1, solute carrier family 2 (facilitated glucose transporter), member 8, glucose transporter type 8
Source: HGNC:13812
Biotype: protein coding gene
DNM1L
(Homo sapiens)Gene
Name: dynamin 1 like
Synonyms: Dnm1p/Vps1p-like protein, DYMPLE, EMPF1, DYNIV-11, dynamin-1-like protein, dynamin-related protein 1, DLP1, dynamin family member proline-rich carboxyl-terminal domain less, DRP1, dynamin-like protein 4, dynamin-like protein IV, OPA5, VPS1, DVLP, HDYNIV, EMPF, dynamin 1-like, FLJ41912
Source: HGNC:2973
Biotype: protein coding gene
SFTPD
(Homo sapiens)Gene
Name: surfactant protein D
Synonyms: SP-D, collectin 7, pulmonary surfactant apoprotein, SFTP4, surfactant, pulmonary-associated protein D, COLEC7, collectin-7, surfactant-associated protein, pulmonary 4, PSP-D, pulmonary surfactant-associated protein D, lung surfactant protein D
Source: HGNC:10803
Biotype: protein coding gene
Ap2m1
(Rattus norvegicus)Gene
Name: adaptor related protein complex 2 subunit mu 1
Synonyms: coat assembly protein complex 50 kD, clathrin coat-associated protein AP50, adaptor-related protein complex 2 subunit mu, clathrin assembly protein complex 2 mu medium chain, MGC105352, adapter-related protein complex 2 subunit mu, clathrin coat assembly protein AP50, Clapm1, coat assembly protein complex, 50 kD, adapter-related protein complex 2 mu subunit, adaptor-related protein complex 2, mu 1 subunit, mu2, AP-2 mu chain, clathrin assembly protein complex 2 medium chain, mu2-adaptin, Ap50, adaptor protein complex AP-2 subunit mu, plasma membrane adaptor AP-2 50 kDa protein, AP-2 complex subunit mu
Source: RGD:620135
Biotype: protein coding gene
ATP6V1B2
(Homo sapiens)Gene
Name: ATPase H+ transporting V1 subunit B2
Synonyms: DOOD, Vma2, H+ transporting two-sector ATPase, V-type proton ATPase subunit B, brain isoform, V-ATPase B2 subunit, ATP6B2, HO57, ATP6B1B2, V-ATPase subunit B 2, ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2, vacuolar H+-ATPase 56,000 subunit, atpase, h+ transporting, lysosomal (vacuolar proton pump), beta 56/58 kda, isoform 2, VATB, vacuolar proton pump subunit B 2, testicular secretory protein Li 65, VPP3, ZLS2, endomembrane proton pump 58 kDa subunit
Source: HGNC:854
Biotype: protein coding gene
Tyrp1
(Mus musculus)Gene
Name: tyrosinase-related protein 1
Synonyms: TRP-1, b, Oca3, isa, TRP1, tyrosinase-related protein, Tyrp, brown, iris stromal atrophy
Source: MGI:98881
Biotype: protein coding gene
FOLR1
(Homo sapiens)Gene
Name: folate receptor alpha
Synonyms: folate receptor 1 (adult), adult folate-binding protein, folate receptor, adult, ovarian tumor-associated antigen MOv18, folate binding protein, NCFTD, FOLR, KB cells FBP, FBP, folate receptor 1, FR-alpha, FRalpha, MOv18
Source: HGNC:3791
Biotype: protein coding gene
CD3G
(Homo sapiens)Gene
Name: CD3 gamma subunit of T-cell receptor complex
Synonyms: CD3g molecule, gamma (CD3-TCR complex), CD3-GAMMA, T-cell antigen receptor complex, gamma subunit of T3, T3G, IMD17, CD3g molecule, T-cell surface glycoprotein CD3 gamma chain, CD3GAMMA, CD3g antigen, gamma polypeptide (TiT3 complex), FLJ17620, FLJ17664, MGC138597, FLJ94613, FLJ79544, CD3g molecule, epsilon (CD3-TCR complex), T-cell receptor T3 gamma chain
Source: HGNC:1675
Biotype: protein coding gene
lin-10
(Caenorhabditis elegans)Gene
Name: abnormal cell LINeage 10
Synonyms: C09H6.2, CELE_C09H6.2
Source: WB:WBGene00002999
Biotype: protein coding gene