Species

Drosophila melanogaster

Symbol

Ror

Name

RTK-like orphan receptor

Synonyms

CG4926
DmHD-2

Biotype

protein coding gene

Automated Description

Predicted to enable Wnt-protein binding activity and transmembrane receptor protein tyrosine kinase activity. Involved in central nervous system development. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in axon and plasma membrane. Is expressed in adult head; central nervous system; and presumptive embryonic/larval peripheral nervous system. Human ortholog(s) of this gene implicated in autosomal recessive Robinow syndrome; autosomal recessive nonsyndromic deafness 108; brachydactyly type B1; and cleft palate. Orthologous to human ROR1 (receptor tyrosine kinase like orphan receptor 1) and ROR2 (receptor tyrosine kinase like orphan receptor 2).

FB Description

Ror (Ror) encodes a transmembrane receptor tyrosine kinase structurally related to vertebrate neural-specific Wnt-binding Ror receptors. It is primarily expressed in the nervous system and it is likely to signal through the ERK MAP kinase pathway.

Cross References

Additional Information

Literature

Orthology

Gene tree: PANTHER:PTHR24416

No data available

Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse

Paralogy

Gene symbol	Rank	Alignment Length (aa)	Similarity %	Identity %	Method Count	Method Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Nrk	1	767	45	30	5 of 8	☑ ☑☐☐☑☑☑☐
sev	2	744	42	28	3 of 8	☑ ☐☐☐☐☑☑☐
Eph	3	738	43	27	3 of 8	☑ ☐☐☐☐☑☑☐
Pvr	4	789	37	22	3 of 8	☑ ☐☐☐☐☑☑☐
CG3277	5	731	38	24	3 of 8	☑ ☐☐☐☐☑☑☐
InR	6	618	46	26	3 of 8	☑ ☐☐☐☐☑☑☐
Egfr	7	703	39	23	3 of 8	☑ ☐☐☐☐☑☑☐
Alk	8	472	52	32	3 of 8	☑ ☐☐☐☐☑☑☐
drl	9	612	42	23	3 of 8	☑ ☐☐☐☐☑☑☐
htl	10	520	45	27	3 of 8	☑ ☐☐☐☐☑☑☐
dnt	11	480	46	26	3 of 8	☑ ☐☐☐☐☑☑☐
btl	12	408	49	31	3 of 8	☑ ☐☐☐☐☑☑☐
Ddr	13	355	52	33	3 of 8	☑ ☐☐☐☐☑☑☐
Ret	14	363	51	31	3 of 8	☑ ☐☐☐☐☑☑☐
Tie	15	391	42	28	3 of 8	☑ ☐☐☐☐☑☑☐
Cad96Ca	16	272	60	37	3 of 8	☑ ☐☐☐☐☑☑☐
Drl-2	17	344	49	26	2 of 8	☐ ☐☐☐☐☑☑☐
smal	18	140	39	24	2 of 8	☐ ☐☐☐☐☑☑☐

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources

FB

Other Sources

BioGRID CRISPR Screen Cell Line Phenotypes

Phenotype Term

Annotation details

References

fertile

View

PMID:30341100

some die during embryonic stage

View

PMID:30341100

viable

View

PMID:30341100

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Disease Associations

	all annotations		all disease by infectious agent	bacterial infectious disease	fungal infectious disease	parasitic infectious disease	viral infectious disease		all disease of anatomical entity	cardiovascular system disease	central nervous system disease	endocrine system disease	gastrointestinal system disease	hematopoietic system disease	immune system disease	integumentary system disease	musculoskeletal system disease	peripheral nervous system disease	reproductive system disease	respiratory system disease	sensory system disease	thoracic disease	urinary system disease		all disease of cellular proliferation	benign neoplasm	cancer	pre-malignant neoplasm		all genetic disease	chromosomal disease	monogenic disease	polygenic disease		all other disease	disease of mental health	disease of metabolism	physical disorder	syndrome
Ror (Dme)

Cell color indicative of annotation volume

No data available

Alleles and Variants

Genome location

Chr2L:10251843...10254686 + (2.84 kb)

Assembly version

R6

Viewer Help

Data currently unavailable; sequence viewer under construction

Allele/Variant Symbol	Allele Synonyms	Category	Variant
Ror^{CR60409-TG4.2}	Ror[CR60409-TG4.2]	allele
Ror^41C	Ror[41C]	allele
Ror²⁷¹	Ror[271]	allele
Ror^GS8107	Ror[GS8107]	allele with one associated variant	NT_033779.5:g.10251860_10251861ins insertion 5 prime UTR variant
Ror^SK5	CG4926[SK5] CG4926^SK5	allele with one associated variant	NT_033779.5:g.10252696_10252705del deletion frameshift variant
Ror⁴	Ror[4]	allele with one associated variant	NT_033779.5:g.10251861_10252906del deletion splice acceptor variant	Yes
Ror^SK2	CG4926[SK2] CG4926^SK2	allele with one associated variant	NT_033779.5:g.10252696_10252697del deletion frameshift variant
Ror^Δ26	Ror[Delta26]	allele with one associated variant	NT_033779.5:g.10252702_10252702del deletion frameshift variant
NT_033779.5:g.10253108G>T		variant	NT_033779.5:g.10253108G>T SNP intron variant
NT_033779.5:g.10252165G>A		variant	NT_033779.5:g.10252165G>A SNP intron variant

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View detailed Alleles/Variants information

Download all Alleles/Variants for all genes of the species

Transgenic Alleles

Species (carrying the transgene)	Allele symbol	Transgenic construct	Expressed components	Knock-down targets	Regulatory regions
Drosophila melanogaster	Ror^EGFP	P{Ror-EGFP}	Ror (Dme) EGFP		Ror (Dme)
Drosophila melanogaster	Ror^GD14377	P{GD14377}		Ror (Dme)	UASt
Drosophila melanogaster	Ror^GD2536	P{GD2536}		Ror (Dme)	UASt
Drosophila melanogaster	Ror^GD40	P{GD40}		Ror (Dme)	UASt
Drosophila melanogaster	Ror^HD_CFD00095	P{HD_CFD00095}		Ror (Dme)	UAS
Drosophila melanogaster	Ror^HMC05341	P{TRiP.HMC05341}		Ror (Dme)	UAS
Drosophila melanogaster	Ror^NIG.4926R	P{NIG.4926R}		Ror (Dme)	UASt
Drosophila melanogaster	Ror^U6.NIG.sgRNA	P{U6-Ror.NIG.sgRNA}		Ror (Dme)
Drosophila melanogaster	Ror^{U6:3.3x.LbcrRNA}	P{U6:3-LbcrRNA-Ror-3x}	Ror (Dme)		snRNA:U6:96Ac (Dme)
Drosophila melanogaster	Ror^UAS.Tag:MYC	P{UAS-Ror.Myc}	Ror (Dme) Tag:MYC		UAS

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Models

No data available

Sequence Feature Viewer

Genome location

Chr2L:10251843...10254686 + (2.84 kb)

Assembly version

R6

Viewer Help

Data currently unavailable; sequence viewer under construction

Sequence Details

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Expression

Primary Sources

Other Sources

	all annotations		all anatomical structures	alimentary part of gastrointestinal system	chemosensory system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mechanosensory system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	vestibulo-auditory system	visual system	endoderm	ectoderm	mesoderm	mesenchyme	adipose tissue	appendage	entire extraembryonic component	imaginal precursor	pharyngeal arch	other		all stages	embryo stage	post embryonic, pre-adult	post-juvenile adult stage		all cellular components	extracellular region	plasma membrane	synapse	cell junction	cell projection	cytoplasmic vesicle	endosome	vacuole	golgi apparatus	endoplasmic reticulum	cytosol	mitochondrion	nucleus	chromosome	cytoskeleton	protein-containing complex	other locations
Ror (Dme)

Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

5 interactor genes based on 6 annotations

Ror molecule type	Interactor gene	Interactor species	Interactor molecule type	Detection methods	Source	Reference
protein	fz2	Drosophila melanogaster	protein	anti tag coimmunoprecipitation	FB:FBrf0240468-4.coIP.WB	PMID:30341100
protein	otk	Drosophila melanogaster	protein	anti tag coimmunoprecipitation	FB:FBrf0240468-5.coIP.WB	PMID:30341100
protein	wg	Drosophila melanogaster	protein	anti tag coimmunoprecipitation	FB:FBrf0240468-1.coIP.WB	PMID:30341100
protein	Wnt4	Drosophila melanogaster	protein	anti tag coimmunoprecipitation	FB:FBrf0240468-2.coIP.WB	PMID:30341100
protein	Wnt5	Drosophila melanogaster	protein	pull down	FB:FBrf0251592-1.PD.WB	PMID:34686333
protein	Wnt5	Drosophila melanogaster	protein	anti tag coimmunoprecipitation	FB:FBrf0240468-3.coIP.WB	PMID:30341100

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Genetic Interactions

No data available