Version: 8.0.0Date: Tue Jan 28 2025
Gene Biological Process: positive regulation of JNK cascade
APP
(Homo sapiens)Gene
Name: amyloid beta precursor protein
Synonyms: AAA, ABETA, PN-II, beta-amyloid peptide(1-42), beta-amyloid peptide, preA4, beta-amyloid peptide(1-40), cerebral vascular amyloid peptide, testicular tissue protein Li 2, peptidase nexin-II, alpha-sAPP, AD1, alzheimer disease amyloid protein, amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease), protease nexin-II, CTFgamma, amyloid beta A4 protein, PN2, APPI, alzheimer disease amyloid A4 protein homolog, CVAP, ABPP
Source: HGNC:620
Biotype: protein coding gene
TNF
(Homo sapiens)Gene
Name: tumor necrosis factor
Synonyms: DIF, tumor necrosis factor ligand superfamily member 2, TNF-a, TNF-alpha, tumor necrotic factor alpha, TNLG1F, TNFSF2, tumor necrosis factor-alpha, TNF, monocyte-derived, TNFA, TNF, macrophage-derived, tumor necrosis factor alpha, tumor necrosis factor ligand 1F, IMD127, TNF superfamily, member 2, APC1 protein, cachectin
Source: HGNC:11892
Biotype: protein coding gene
Tnf
(Mus musculus)Gene
Name: tumor necrosis factor
Synonyms: DIF, tumor necrosis factor-alpha, Tnfa, TNF alpha, TNF-alpha, TNFalpha, tumor necrosis factor, alpha, Tnfsf1a, RATTNF
Source: MGI:104798
Biotype: protein coding gene
App
(Mus musculus)Gene
Name: amyloid beta precursor protein
Synonyms: Cvap, Abeta, Alzheimer disease amyloid beta protein, cerebrovascular amyloid peptide, protease nexin II, expressed sequence AL024401, AL024401, RIKEN cDNA E030013M08 gene, betaAPP, E030013M08Rik, Adap, appican
Source: MGI:88059
Biotype: protein coding gene
Tlr4
(Mus musculus)Gene
Name: toll-like receptor 4
Synonyms: lipopolysaccharide response, RAS-like, family 2, locus 8, Rasl2-8, Lps
Source: MGI:96824
Biotype: protein coding gene
HRAS
(Homo sapiens)Gene
Name: HRas proto-oncogene, GTPase
Synonyms: HAMSV, Ras family small GTP binding protein H-Ras, H-RASIDX, GTPase KRas, RASH1, Harvey rat sarcoma viral oncoprotein, ha-Ras, transformation gene: oncogene HAMSV, GTP- and GDP-binding peptide B, c-Ki-ras, p19 H-RasIDX protein, H-Ras-1, Ha-Ras1 proto-oncoprotein, p21ras, C-H-RAS, N-RAS, c-has/bas p21 protein, HRAS1, RASK2, Harvey rat sarcoma viral oncogene homolog, GTPase HRas, CTLO, Ki-Ras, c-K-ras, K-RAS, c-ras-Ki-2 activated oncogene, C-BAS/HAS, K-Ras 2, KRAS, C-HA-RAS1, v-Ha-ras Harvey rat sarcoma viral oncogene homolog, KRAS2, transforming protein p21
Source: HGNC:5173
Biotype: protein coding gene
TLR4
(Homo sapiens)Gene
Name: toll like receptor 4
Synonyms: TLR-4, hToll, CD284, ARMD10, homolog of Drosophila toll, TOLL, toll-like receptor 4
Source: HGNC:11850
Biotype: protein coding gene
Il1b
(Mus musculus)Gene
Name: interleukin 1 beta
Synonyms: IL-1F2, IL-1B, IL-1beta, Il-1b
Source: MGI:96543
Biotype: protein coding gene
IL1B
(Homo sapiens)Gene
Name: interleukin 1 beta
Synonyms: preinterleukin 1 beta, IL1F2, interleukin-1 beta, catabolin, IL-1, IL1-BETA, IL1beta, IL-1 beta, interleukin 1beta, interleukin 1, beta, pro-interleukin-1-beta
Source: HGNC:5992
Biotype: protein coding gene
Fcgr2b
(Mus musculus)Gene
Name: Fc receptor, IgG, low affinity IIb
Synonyms: LyM-1, Fc[g]RII, RIKEN cDNA F630109E10 gene, lymphocyte antigen 17, Fcr-3, Fcr-2, AI528646, FcgRII, CD32, Ly-17, Fcgr2a, Fcgr2, Fc gamma RIIB, F630109E10Rik, Lym-1, Ly-m20, FcgammaRIIB2, expressed sequence AI528646, FCRII, lymphocyte antigen m20, Fc receptor, IgG, low affinity IIa, FcgammaRIIB, Fc-gamma receptor 2, Fc receptor, IgG, low affinity II, Fc-gamma receptor 3
Source: MGI:95499
Biotype: protein coding gene
HMGB1
(Homo sapiens)Gene
Name: high mobility group box 1
Synonyms: HMG3, high-mobility group box 1, high-mobility group (nonhistone chromosomal) protein 1, SBP-1, high mobility group protein 1, high mobility group protein B1, Sulfoglucuronyl carbohydrate binding protein, Amphoterin, HMG-1, DKFZp686A04236, HMG1
Source: HGNC:4983
Biotype: protein coding gene
CDC42
(Homo sapiens)Gene
Name: cell division cycle 42
Synonyms: G25K, GTP-binding protein, 25kD, GTP binding protein, 25kDa, small GTP binding protein CDC42, G25K GTP-binding protein, cell division cycle 42 (GTP binding protein, 25kDa), CDC42Hs, dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD)), growth-regulating protein, dJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD)), TKS, cell division control protein 42 homolog
Source: HGNC:1736
Biotype: protein coding gene
Tnfsf11
(Mus musculus)Gene
Name: tumor necrosis factor (ligand) superfamily, member 11
Synonyms: ODF, RANKL, OPGL, TRANCE, Trance, TNF-related activation-induced cytokine, osteoclast differentiation factor, Ly109l
Source: MGI:1100089
Biotype: protein coding gene
Ager
(Mus musculus)Gene
Name: advanced glycosylation end product-specific receptor
Synonyms: RAGE
Source: MGI:893592
Biotype: protein coding gene
Lmnb1
(Mus musculus)Gene
Name: lamin B1
Synonyms: Not Available
Source: MGI:96795
Biotype: protein coding gene
Tnf
(Rattus norvegicus)Gene
Name: tumor necrosis factor
Synonyms: tumor necrosis factor ligand superfamily member 2, TNF-a, TNF-alpha, tumor necrosis factor (TNF superfamily, member 2), MGC124630, RATTNF, tumor necrosis factor-alpha, Tnfa, tumor necrosis factor-like, tumor necrosis factor alpha, tumor necrosis factor superfamily member 2, tumor necrosis factor superfamily, member 2, LOC103694380, cachectin
Source: RGD:3876
Biotype: protein coding gene
Myd88
(Mus musculus)Gene
Name: myeloid differentiation primary response gene 88
Synonyms: Not Available
Source: MGI:108005
Biotype: protein coding gene
Tnik
(Mus musculus)Gene
Name: TRAF2 and NCK interacting kinase
Synonyms: C530008O15Rik, RIKEN cDNA 1500031A17 gene, RGD1561817, 4831440I19Rik, expressed sequence AI451411, RIKEN cDNA C630040K21 gene, RIKEN cDNA 4831440I19 gene, 1500031A17Rik, AI451411, C630040K21Rik, RIKEN cDNA C530008O15 gene
Source: MGI:1916264
Biotype: protein coding gene
RIPK1
(Homo sapiens)Gene
Name: receptor interacting serine/threonine kinase 1
Synonyms: receptor (TNFRSF)-interacting serine-threonine kinase 1, IMD57, receptor-interacting protein 1, serine/threonine-protein kinase RIP, receptor interacting protein, receptor-interacting protein kinase 1, AIEFL, cell death protein RIP, FLJ39204, RIP, RIP-1, RIP1, receptor-interacting serine/threonine-protein kinase 1
Source: HGNC:10019
Biotype: protein coding gene
Plcb1
(Mus musculus)Gene
Name: phospholipase C, beta 1
Synonyms: RATPHOSPHB, 3110043I21Rik, AI132408, RIKEN cDNA 3110043I21 gene, Phosphb, expressed sequence AI132408, PLCbeta1, PLC'1, mKIAA0581
Source: MGI:97613
Biotype: protein coding gene
NOD2
(Homo sapiens)Gene
Name: nucleotide binding oligomerization domain containing 2
Synonyms: BLAU, CD, caspase recruitment domain protein 15, caspase recruitment domain family, member 15, NOD2B, IBD1, YAOS, NOD-like receptor C2, ACUG, NLRC2, PSORAS1, nucleotide-binding oligomerization domain-containing protein 2, NLR family, CARD domain containing 2, nucleotide-binding oligomerization domain containing 2, BLAUS, caspase recruitment domain-containing protein 15, inflammatory bowel disease protein 1, Inflammatory bowel disease-1 (Crohn disease), CARD15, nucleotide-binding oligomerization domain 2, nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 2, CLR16.3
Source: HGNC:5331
Biotype: protein coding gene
CCN2
(Homo sapiens)Gene
Name: cellular communication network factor 2
Synonyms: connective tissue growth factor, IBP-8, insulin-like growth factor-binding protein 8, hypertrophic chondrocyte-specific protein 24, MGC102839, IGF-binding protein 8, NOV2, IGFBP-8, IGFBP8, HCS24, CCN family member 2, CTGF
Source: HGNC:2500
Biotype: protein coding gene
Taok2
(Mus musculus)Gene
Name: TAO kinase 2
Synonyms: MAP3K17, Tao2, TAO2, TAO1, mKIAA0881, PSK1, 1110033K02Rik, RIKEN cDNA 1110033K02 gene
Source: MGI:1915919
Biotype: protein coding gene
Dab2
(Mus musculus)Gene
Name: disabled 2, mitogen-responsive phosphoprotein
Synonyms: RIKEN cDNA D630005B22 gene, AI957090, AA960054, p96, Doc-2, D630005B22Rik, expressed sequence AI957090, expressed sequence AA960054, D15Wsu122e, Doc2, 5730435J12Rik, RIKEN cDNA 5730435J12 gene, DNA segment, Chr 15, Wayne State University 122, expressed
Source: MGI:109175
Biotype: protein coding gene
STK3
(Homo sapiens)Gene
Name: serine/threonine kinase 3
Synonyms: MST2, STE20-like kinase MST2, KRS1, mammalian STE20-like protein kinase 2, FLJ90748, KB-1458E12.1, serine/threonine kinase 3 (STE20 homolog, yeast), hippo homolog, MST-2, serine/threonine kinase 3 (Ste20, yeast homolog), serine/threonine-protein kinase 3, serine/threonine-protein kinase Krs-1, hippo (Drosophila) homolog
Source: HGNC:11406
Biotype: protein coding gene
MAP3K7
(Homo sapiens)Gene
Name: mitogen-activated protein kinase kinase kinase 7
Synonyms: TGF1a, MEKK7, TAK1, TGF-beta-activated kinase 1, FMD2, TGF-beta activated kinase 1, CSCF, transforming growth factor-beta-activated kinase 1
Source: HGNC:6859
Biotype: protein coding gene
Hras
(Mus musculus)Gene
Name: Harvey rat sarcoma virus oncogene
Synonyms: Hras-1, H-ras, c-rasHa, Harvey rat sarcoma virus oncogene 1, HRAS1, c-H-ras, Ha-ras, Harvey-ras, Hras1
Source: MGI:96224
Biotype: protein coding gene
TAOK2
(Homo sapiens)Gene
Name: TAO kinase 2
Synonyms: PSK-1, serine/threonine-protein kinase TAO2, TAO1, PSK, KIAA0881, PSK1, prostate derived STE20-like kinase PSK, kinase from chicken homolog C, prostate-derived STE20-like kinase 1, hKFC-C, thousand and one amino acid protein kinase 2, MAP3K17, TAO2, Tao2beta, PSK1-BETA, prostate-derived sterile 20-like kinase 1, thousand and one amino acid protein kinase, thousand and one amino acid protein 2
Source: HGNC:16835
Biotype: protein coding gene
SDCBP
(Homo sapiens)Gene
Name: syndecan binding protein
Synonyms: melanoma differentiation-associated protein 9, melanoma differentiation associated protein-9, SYCL, pro-TGF-alpha cytoplasmic domain-interacting protein 18, MDA-9, MDA9, TACIP18, SDCBP1, syndecan-binding protein 1, scaffold protein Pbp1, ST1, syndecan binding protein (syntenin), syntenin-1
Source: HGNC:10662
Biotype: protein coding gene
ANKRD6
(Homo sapiens)Gene
Name: ankyrin repeat domain 6
Synonyms: FLJ34916, ankyrin repeat domain-containing protein 6, diego homolog, FLJ12637, diversin
Source: HGNC:17280
Biotype: protein coding gene
FLT4
(Homo sapiens)Gene
Name: fms related receptor tyrosine kinase 4
Synonyms: tyrosine-protein kinase receptor FLT4, VEGFR3, VEGF receptor-3, vascular endothelial growth factor receptor 3, fms-related tyrosine kinase 4, FLT-4, fms related tyrosine kinase 4, soluble VEGFR3 variant 1, LMPHM1, CHTD7, soluble VEGFR3 variant 3, fms-like tyrosine kinase 4, soluble VEGFR3 variant 2, FLT41, VEGFR-3, primary congenital lymphedema, Feline McDonough Sarcoma (FMS)-like tyrosine kinase 4, PCL, LMPH1A
Source: HGNC:3767
Biotype: protein coding gene
Map2k4
(Mus musculus)Gene
Name: mitogen-activated protein kinase kinase 4
Synonyms: MKK4, SAPK/Erk/kinase 1, Serk1, JNKK1, Sek1
Source: MGI:1346869
Biotype: protein coding gene
Map3k7
(Rattus norvegicus)Gene
Name: mitogen activated protein kinase kinase kinase 7
Synonyms: mitogen-activated protein kinase kinase kinase 7-like, Tak1, TGF-beta activated kinase 1, LOC100910771, mitogen-activated protein kinase kinase kinase 7
Source: RGD:1309438
Biotype: protein coding gene
Map2k4
(Rattus norvegicus)Gene
Name: mitogen activated protein kinase kinase 4
Synonyms: dual specificity mitogen-activated protein kinase kinase 4, LOC287398, MKK4, SAPK/ERK kinase 1, MAP2K4delta, Sek1
Source: RGD:1307040
Biotype: protein coding gene
Ripk1
(Mus musculus)Gene
Name: receptor (TNFRSF)-interacting serine-threonine kinase 1
Synonyms: Rip1, Rinp, receptor interacting protein
Source: MGI:108212
Biotype: protein coding gene
App
(Rattus norvegicus)Gene
Name: amyloid beta precursor protein
Synonyms: amyloid beta (A4) precursor protein, Abeta, amyloid beta A4 protein, AG, alzheimer disease amyloid A4 protein homolog, amyloidogenic glycoprotein, amyloid A4, ABPP
Source: RGD:2139
Biotype: protein coding gene
Rac1
(Drosophila melanogaster)Gene
Name: Rac1
Synonyms: Rac GTPase, DracA, Dm Rac1, dRac1, DmRAC1, D-Rac1, rac-1, DRac, Drac1, 2248, rac, Rac3, DmRAC, RAC1, Drac1a, D-Rac 1, DRac1, GTPase Rac1, Rac-GTP, rac1, Rac-1, CED-10, RacA, Drac, P40792, Rac, DRacA, drac1, D-Rac, Dmrac1, CG2248, dRac
Source: FB:FBgn0010333
Biotype: protein coding gene
Ptk2b
(Rattus norvegicus)Gene
Name: protein tyrosine kinase 2 beta
Synonyms: cell adhesion kinase beta, calcium-regulated non-receptor proline-rich tyrosine kinase, CAKbeta, CAKB, PTK2B protein tyrosine kinase 2 beta, proline-rich tyrosine kinase 2, MGC124628, CAK beta, FADK 2, CADTK, calcium-dependent tyrosine kinase, Pyk2, CAK-beta, focal adhesion kinase 2, PTK2 protein tyrosine kinase 2 beta, protein-tyrosine kinase 2-beta
Source: RGD:628758
Biotype: protein coding gene
Cd27
(Mus musculus)Gene
Name: CD27 antigen
Synonyms: tumor necrosis factor receptor superfamily, member 7, Tp55, Tnfrsf7, S152
Source: MGI:88326
Biotype: protein coding gene
Il1a
(Mus musculus)Gene
Name: interleukin 1 alpha
Synonyms: IL-1F1, IL-1 alpha, Il-1a
Source: MGI:96542
Biotype: protein coding gene
Gadd45a
(Mus musculus)Gene
Name: growth arrest and DNA-damage-inducible 45 alpha
Synonyms: expressed sequence AA545191, AA545191, Gadd45, DNA-damage inducible transcript 1, Ddit1
Source: MGI:107799
Biotype: protein coding gene
Mbip
(Mus musculus)Gene
Name: MAP3K12 binding inhibitory protein 1
Synonyms: 4933408E06Rik, RIKEN cDNA 4933408E06 gene, MGC:7681
Source: MGI:1918320
Biotype: protein coding gene
Dixdc1
(Mus musculus)Gene
Name: DIX domain containing 1
Synonyms: Ccd1, BC048182, MGC:61302, mKIAA1735, RIKEN cDNA 4930563F16 gene, cDNA sequence BC048182, 4930563F16Rik
Source: MGI:2679721
Biotype: protein coding gene
TNIK
(Homo sapiens)Gene
Name: TRAF2 and NCK interacting kinase
Synonyms: TRAF2 and NCK-interacting protein kinase, MRT54
Source: HGNC:30765
Biotype: protein coding gene
Nox1
(Rattus norvegicus)Gene
Name: NADPH oxidase 1
Synonyms: mitogenic oxidase 1, MOX-1, NOH-1, NOX-1, NADH/NADPH mitogenic oxidase subunit p65-mox, MOX1
Source: RGD:620598
Biotype: protein coding gene
Map4k4
(Mus musculus)Gene
Name: mitogen-activated protein kinase kinase kinase kinase 4
Synonyms: 9430080K19Rik, expressed sequence AU045934, NCK interacting kinase, Nik, AU045934, AU043147, expressed sequence AW046177, AW046177, RIKEN cDNA 9430080K19 gene, expressed sequence AU043147
Source: MGI:1349394
Biotype: protein coding gene
Pvr
(Drosophila melanogaster)Gene
Name: PDGF- and VEGF-receptor related
Synonyms: PDGF- and VEGF-Receptor Related, Vegf, vgr1, CG8222, VEGF receptor, PDGF- and VEGF- receptor related, PVR, CT24332, PDGF- and VEGF Receptor related, Vegfr-b, PVF receptor, platelet-derived growth factor/vascular endothelial growth factor receptor, Vegfr-c, VEGFR, 8222, VEGFR-A, PDGF receptor, PDGF- and VEGF-related receptor, Vascular endothelial growth factor receptor, pvr, PvR, Vegfr, stasis, PDGF/VEGF receptor, VGR1, Vgr1, Vascular endothelial growth factor receptor-1 like, DmVEGFR, stai
Source: FB:FBgn0032006
Biotype: protein coding gene
Tlr3
(Mus musculus)Gene
Name: toll-like receptor 3
Synonyms: AI957183, expressed sequence AI957183
Source: MGI:2156367
Biotype: protein coding gene
Hmgb1
(Mus musculus)Gene
Name: high mobility group box 1
Synonyms: Ac2-008, amphoterin, DEF, high mobility group protein 1, SBP-1, p30, HMG-1, Hmg1
Source: MGI:96113
Biotype: protein coding gene
MYD88
(Homo sapiens)Gene
Name: MYD88 innate immune signal transduction adaptor
Synonyms: MYD88, innate immune signal transduction adaptor, MYD88D, mutant myeloid differentiation primary response 88, myeloid differentiation primary response 88, IMD68, WM1, TLR adaptor MYD88, myeloid differentiation primary response gene (88), myeloid differentiation primary response protein MyD88
Source: HGNC:7562
Biotype: protein coding gene