Version: 8.1.0Date: Fri Apr 18 2025
Gene Molecular Function: DNA binding Molecular Function: ATP binding
ATM
(Homo sapiens)Gene
Name: ATM serine/threonine kinase
Synonyms: serine/threonine kinase ATM, TEL1, telomere maintenance 1, homolog, MGC74674, human phosphatidylinositol 3-kinase homolog, ATDC, DKFZp781A0353, truncated ATM serine/threonine kinase, ATA, AT mutated, ataxia telangiectasia mutated, ATC, ataxia telangiectasia mutated (includes complementation groups A, C and D), TEL1, ATD, ATE, A-T mutated, serine-protein kinase ATM, TELO1, AT1
Source: HGNC:795
Biotype: protein coding gene
EGFR
(Homo sapiens)Gene
Name: epidermal growth factor receptor
Synonyms: PIG61, receptor tyrosine-protein kinase erbB-1, NNCIS, epidermal growth factor receptor tyrosine kinase domain, EGFR vIII, proto-oncogene c-ErbB-1, cell growth inhibiting protein 40, erb-b2 receptor tyrosine kinase 1, ERRP, ERBB, epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian), ERBB1, erythroblastic leukemia viral (v-erb-b) oncogene homolog, mENA, avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, cell proliferation-inducing protein 61, HER1, NISBD2
Source: HGNC:3236
Biotype: protein coding gene
MTOR
(Homo sapiens)Gene
Name: mechanistic target of rapamycin kinase
Synonyms: tyrosine-protein kinase mTOR, mechanistic target of rapamycin, rapamycin and FKBP12 target 1, rapamycin target protein 1, mammalian target of rapamycin, rapamycin associated protein FRAP2, FRAP1, RAFT1, FRAP2, FKBP12-rapamycin complex-associated protein 1, mechanistic target of rapamycin (serine/threonine kinase), FLJ44809, FRAP, SKS, RAPT1, serine/threonine-protein kinase mTOR, FKBP-rapamycin associated protein, FK506 binding protein 12-rapamycin associated protein 1, FK506-binding protein 12-rapamycin complex-associated protein 1, FK506 binding protein 12-rapamycin associated protein 2
Source: HGNC:3942
Biotype: protein coding gene
RECQL
(Homo sapiens)Gene
Name: RecQ like helicase
Synonyms: RecQ protein-like (DNA helicase Q1-like), RecQ1, recQ protein-like 1, DNA helicase, RecQ-like type 1, ATP-dependent DNA helicase Q1, DNA helicase Q1-like, RECON, DNA 3'-5' helicase Q1, DNA-dependent ATPase Q1, RecQ helicase-like, RECQL1
Source: HGNC:9948
Biotype: protein coding gene
ACTB
(Homo sapiens)Gene
Name: actin beta
Synonyms: actin, cytoplasmic 1, DDS1, beta cytoskeletal actin, CSMH, actin, beta, PS1TP5BP1, BNS, PS1TP5-binding protein 1, BKRNS, I(2)-actin, BRWS1, THC8
Source: HGNC:132
Biotype: protein coding gene
SGS1
(Saccharomyces cerevisiae)Gene
Name: Slow Growth Suppressor
Synonyms: YMR190C
Source: SGD:S000004802
Biotype: protein coding gene
NLRP3
(Homo sapiens)Gene
Name: NLR family pyrin domain containing 3
Synonyms: caterpiller protein 1.1, PYRIN-containing APAF1-like protein 1, cryopyrin, NACHT, LRR and PYD domains - containing protein 3, CIAS1, deafness, autosomal dominant 34, cold autoinflammatory syndrome 1, NACHT, LRR and PYD domains-containing protein 3, FCAS, cryopyrin, NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3, AII/AVP receptor-like, nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3, FCAS1, AGTAVPRL, DFNA34, AII, CLR1.1, MWS, PYPAF1, NACHT, LRR and PYD containing protein 3, AII/AVP, NLR family, pyrin domain containing 3, FLJ95925, NALP3, FCU, C1orf7, angiotensin/vasopressin receptor AII/AVP-like, AVP, KEFH
Source: HGNC:16400
Biotype: protein coding gene
ERCC2
(Homo sapiens)Gene
Name: ERCC excision repair 2, TFIIH core complex helicase subunit
Synonyms: general transcription and DNA repair factor IIH helicase subunit XPD, TTD, TFIIH basal transcription factor complex 80 kDa subunit, TTD1, TFIIH basal transcription factor complex helicase subunit, COFS2, XPD, DNA 5'-3' helicase XPD, EM9, xeroderma pigmentosum complementary group D, excision repair cross-complementing rodent repair deficiency, complementation group 2, xeroderma pigmentosum group D-complementing protein, BTF2 p80, basic transcription factor 2 80 kDa subunit, trichothiodystrophy, MGC102762, DNA repair protein complementing XP-D cells, MGC126218, TFIIH basal transcription factor complex helicase XPB subunit, MGC126219, excision repair cross-complementation group 2, TFIIH basal transcription factor complex helicase XPD subunit, TFIIH subunit XPD, CXPD, TFIIH, TFIIH p80, TFIIH 80 kDa subunit, DNA excision repair protein ERCC-2
Source: HGNC:3434
Biotype: protein coding gene
ATR
(Homo sapiens)Gene
Name: ATR serine/threonine kinase
Synonyms: FRAP-related protein 1, MEC1, MEC1, mitosis entry checkpoint 1, homolog, ataxia telangiectasia and Rad3-related protein, ataxia telangiectasia and Rad3 related, FRP1, FRAP-related protein-1, SCKL1, serine/threonine-protein kinase ATR, protein kinase ATR, SCKL, FCTCS, Rad3 related protein
Source: HGNC:882
Biotype: protein coding gene
DNA2
(Homo sapiens)Gene
Name: DNA replication helicase/nuclease 2
Synonyms: RTS4, DNA replication helicase 2 homolog, MGC133297, PEOA6, DNA2 (DNA replication helicase, yeast, homolog)-like, DNA2 DNA replication helicase 2-like, KIAA0083, FLJ10063, DNA replication ATP-dependent helicase/nuclease DNA2, DNA2L, DNA2-like helicase, SCKL8, hDNA2, DNA replication ATP-dependent helicase-like homolog
Source: HGNC:2939
Biotype: protein coding gene
ORC1
(Homo sapiens)Gene
Name: origin recognition complex subunit 1
Synonyms: ORC1L, PARC1, replication control protein 1, origin recognition complex, subunit 1, S. cerevisiae, homolog-like, origin recognition complex 1, origin recognition complex, subunit 1-like, HSORC1, origin recognition complex, subunit 1 homolog
Source: HGNC:8487
Biotype: protein coding gene
WRNIP1
(Homo sapiens)Gene
Name: WRN helicase interacting protein 1
Synonyms: WHIP, RP11-420G6.2, CFAP93, putative helicase RUVBL, ATPase WRNIP1, FAP93, Werner helicase interacting protein 1, Werner helicase-interacting protein 1, bA420G6.2, FLJ22526
Source: HGNC:20876
Biotype: protein coding gene
PIF1
(Homo sapiens)Gene
Name: PIF1 5'-to-3' DNA helicase
Synonyms: DNA helicase PIF1, ATP-dependent DNA helicase PIF1, PIF1/RRM3 DNA helicase-like protein, C15orf20, petite integration frequency 1, PIF1 5'-to-3' DNA helicase homolog, PIF1 DNA helicase, chromosome 15 open reading frame 20, DNA helicase homolog PIF1, PIF, DNA repair and recombination helicase PIF1
Source: HGNC:26220
Biotype: protein coding gene
RAD54L
(Homo sapiens)Gene
Name: RAD54 like
Synonyms: RAD54-like (S. cerevisiae), hRAD54, RAD54 homolog, HR54, RAD54 like (S. cerevisiae), DNA repair and recombination protein RAD54-like, hHR54, RAD54A
Source: HGNC:9826
Biotype: protein coding gene
Runx1
(Mus musculus)Gene
Name: runt related transcription factor 1
Synonyms: PEBP2-alpha, AI462102, Pebp2a2, expressed sequence AI462102, CBF-alpha-2, Cbfa2, PEA2-alpha, runt domain, alpha subunit 2, core binding factor alpha 2, Aml1, AML1
Source: MGI:99852
Biotype: protein coding gene
DDX3X
(Homo sapiens)Gene
Name: DEAD-box helicase 3 X-linked
Synonyms: DEAD box, X isoform, CAP-Rf, DDX3, DEAD box protein 3, X-chromosomal, DDX14, HLP2, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked, ATP-dependent RNA helicase DDX3X, MRX102, helicase-like protein 2, DEAD-box helicase 3, X-linked, DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked, helicase like protein 2, DBX, DEAD/H box-3, MRXSSB
Source: HGNC:2745
Biotype: protein coding gene
TEL1
(Saccharomyces cerevisiae)Gene
Name: TELomere maintenance
Synonyms: YBL088C
Source: SGD:S000000184
Biotype: protein coding gene
IGHMBP2
(Homo sapiens)Gene
Name: immunoglobulin mu DNA binding protein 2
Synonyms: zinc finger, AN1-type domain 7, ZFAND7, GF-1, ATP-dependent helicase IGHMBP2, DNA-binding protein SMUBP-2, SMARD1, HCSA, cardiac transcription factor 1, HMN6, FLJ41171, CATF1, SMUBP2, HMNR1, FLJ34220, immunoglobulin mu-binding protein 2, immunoglobulin mu binding protein 2, glial factor 1, CMT2S
Source: HGNC:5542
Biotype: protein coding gene
HNRNPU
(Homo sapiens)Gene
Name: heterogeneous nuclear ribonucleoprotein U
Synonyms: EIEE54, C1orf199, FLJ30202, hnRNP U, system n1 na+ and h+-coupled glutamine transporter, p120 nuclear protein, HNRPU, GRIP120, heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A), scaffold attachment factor A, SAFA, HNRNPU antisense RNA 1, transporter protein, pp120, U21.1, HNRNPU-AS1, NCRNA00201, nuclear p120 ribonucleoprotein, SAF-A, DEE54
Source: HGNC:5048
Biotype: protein coding gene
SETX
(Homo sapiens)Gene
Name: senataxin
Synonyms: AOA2, SCAR1, SCAN2, DKFZp781B151, ALS4, STEX, FLJ43459, Sen1, SEN1 homolog, FLJ12840, KIAA0625, bA479K20.2, amyotrophic lateral sclerosis 4, spinocerebellar ataxia, recessive, non-Friedreich type 1, probable helicase senataxin
Source: HGNC:445
Biotype: protein coding gene
RAD50
(Homo sapiens)Gene
Name: RAD50 double strand break repair protein
Synonyms: hRad50, DNA repair protein RAD50, RAD502, RAD50-2, RAD50 homolog, NBSLD
Source: HGNC:9816
Biotype: protein coding gene
Ddx1
(Mus musculus)Gene
Name: DEAD box helicase 1
Synonyms: expressed sequence AA409185, AA409185, DEAD (Asp-Glu-Ala-Asp) box polypeptide 1
Source: MGI:2144727
Biotype: protein coding gene
G3BP1
(Homo sapiens)Gene
Name: G3BP stress granule assembly factor 1
Synonyms: DNA helicase VIII, MGC111040, Ras-GTPase-activating protein SH3-domain-binding protein, GAP SH3 domain-binding protein 1, ATP-dependent DNA helicase VIII, ras GTPase-activating protein-binding protein 1, G3BP, G3BP-1, GTPase activating protein (SH3 domain) binding protein 1, GAP binding protein, HDH-VIII, RasGAP-associated endoribonuclease G3BP
Source: HGNC:30292
Biotype: protein coding gene
MAPK1
(Homo sapiens)Gene
Name: mitogen-activated protein kinase 1
Synonyms: PRKM1, PRKM2, NS13, p41mapk, mitogen activated protein kinase 1, ERT1, p41, p40, P42MAPK, extracellular signal-regulated kinase 2, ERK-2, ERK2, p38, MAP kinase 2, p42-MAPK, MAP kinase isoform p42, MAP kinase 1, mitogen-activated protein kinase 2, MAPK2, protein tyrosine kinase ERK2, MAPK 2, ERK
Source: HGNC:6871
Biotype: protein coding gene
CDK9
(Homo sapiens)Gene
Name: cyclin dependent kinase 9
Synonyms: tat-associated kinase complex catalytic subunit, CDC2-related kinase, CTK1, CDC2L4, PITALRE, serine/threonine-protein kinase PITALRE, C-2k, cell division cycle 2-like protein kinase 4, serine/threonine protein kinase PITALRE, cell division protein kinase 9, TAK, cyclin-dependent kinase 9
Source: HGNC:1780
Biotype: protein coding gene
Mtor
(Mus musculus)Gene
Name: mechanistic target of rapamycin kinase
Synonyms: expressed sequence AI327068, 2610315D21Rik, flat, AI327068, RAFT1, flat-top, FKBP-rapamycin-associated protein FRAP, Frap1, mechanistic target of rapamycin (serine/threonine kinase), RAPT1, RIKEN cDNA 2610315D21 gene, FK506 binding protein 12-rapamycin associated protein 1
Source: MGI:1928394
Biotype: protein coding gene
Hnrnpu
(Mus musculus)Gene
Name: heterogeneous nuclear ribonucleoprotein U
Synonyms: expressed sequence AW557595, AI256620, AL024194, expressed sequence C86794, SP120, hnRNP U, AI503316, expressed sequence AI503316, AA408410, scaffold attachment factor A, expressed sequence AI256620, AW557595, C86794, expressed sequence AL024194, AL024437, SN1, Sp120, expressed sequence AL024437, Hnrpu, SAF-A, expressed sequence AA408410
Source: MGI:1858195
Biotype: protein coding gene
RAD5
(Saccharomyces cerevisiae)Gene
Name: RADiation sensitive
Synonyms: YLR032W, SNM2, REV2
Source: SGD:S000004022
Biotype: protein coding gene
Mki67
(Mus musculus)Gene
Name: antigen identified by monoclonal antibody Ki 67
Synonyms: Ki-67, D630048A14Rik, RIKEN cDNA D630048A14 gene, Ki67
Source: MGI:106035
Biotype: protein coding gene
Atad5
(Mus musculus)Gene
Name: ATPase family, AAA domain containing 5
Synonyms: C130052G03Rik, RIKEN cDNA C130052G03 gene, RGD1561464, LOC237877, gene model 17, (NCBI), Gm17
Source: MGI:2442925
Biotype: protein coding gene
MLH1
(Saccharomyces cerevisiae)Gene
Name: MutL Homolog
Synonyms: YMR167W, PMS2
Source: SGD:S000004777
Biotype: protein coding gene
CDC5
(Saccharomyces cerevisiae)Gene
Name: Cell Division Cycle
Synonyms: MSD2, PKX2, YMR001C
Source: SGD:S000004603
Biotype: protein coding gene
Top2a
(Mus musculus)Gene
Name: topoisomerase (DNA) II alpha
Synonyms: DNA Topoisomerase II alpha, Top-2, topoisomerase (DNA) II
Source: MGI:98790
Biotype: protein coding gene
Cgas
(Mus musculus)Gene
Name: cyclic GMP-AMP synthase
Synonyms: Mb21d1, RIKEN cDNA E330016A19 gene, Mab-21 domain containing 1, E330016A19Rik
Source: MGI:2442261
Biotype: protein coding gene
Prkdc
(Mus musculus)Gene
Name: protein kinase, DNA activated, catalytic polypeptide
Synonyms: DNAPDcs, DNA-PKcs, doxorubicin nephropathy, expressed sequence AI326420, XRCC7, DNA-PK, AU019811, dxnph, severe combined immunodeficiency, DOXNPH, expressed sequence AU019811, slip, AI326420, scid
Source: MGI:104779
Biotype: protein coding gene
RAD3
(Saccharomyces cerevisiae)Gene
Name: RADiation sensitive
Synonyms: REM1, YER171W
Source: SGD:S000000973
Biotype: protein coding gene
SWR1
(Saccharomyces cerevisiae)Gene
Name: SWi2/snf2-Related
Synonyms: YDR334W
Source: SGD:S000002742
Biotype: protein coding gene
INO80
(Saccharomyces cerevisiae)Gene
Name: INOsitol requiring
Synonyms: YGL150C
Source: SGD:S000003118
Biotype: protein coding gene
Runx2
(Mus musculus)Gene
Name: runt related transcription factor 2
Synonyms: CBF-alpha-1, core binding factor, Cbf, OSF-2, Pebpa2a, Cbfa1, core binding factor alpha 1, SL3-3 enhancer factor 1, PEBP2 alpha A, AML3, polyomavirus enhancer binding factor 2 (PEBP2), Osf2, PEBP2aA
Source: MGI:99829
Biotype: protein coding gene
let-418
(Caenorhabditis elegans)Gene
Name: LEThal 418
Synonyms: chd-4, F26F12.7, evl-11, CELE_F26F12.7
Source: WB:WBGene00002637
Biotype: protein coding gene
SHPRH
(Homo sapiens)Gene
Name: SNF2 histone linker PHD RING helicase
Synonyms: FLJ27258, MGC134886, FLJ45012, RAD5, KIAA2023, E3 ubiquitin-protein ligase SHPRH, 2610103K11Rik, FLJ37625, SNF2, histone-linker, PHD and RING finger domain-containing helicase, FLJ90837, bA545I5.2, RING-type E3 ubiquitin transferase SHPRH, SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase
Source: HGNC:19336
Biotype: protein coding gene
HRQ1
(Saccharomyces cerevisiae)Gene
Name: Homologous to RecQ protein
Synonyms: YDR291W
Source: SGD:S000002699
Biotype: protein coding gene
Recql4
(Mus musculus)Gene
Name: RecQ protein-like 4
Synonyms: Not Available
Source: MGI:1931028
Biotype: protein coding gene
RAD51
(Saccharomyces cerevisiae)Gene
Name: RADiation sensitive
Synonyms: YER095W, MUT5
Source: SGD:S000000897
Biotype: protein coding gene
HSPD1
(Homo sapiens)Gene
Name: heat shock protein family D (Hsp60) member 1
Synonyms: HSP60, GROEL, short heat shock protein 60 Hsp60s1, heat shock 60kDa protein 1 (chaperonin), heat shock protein 60 (liver), mitochondrial matrix protein P1, CPN60, P60 lymphocyte protein, HuCHA60, HSP-60, 60 kDa heat shock protein, mitochondrial, HLD4, 60 kDa chaperonin, spastic paraplegia 13 (autosomal dominant), heat shock protein 65, HSP65, heat shock protein family D member 1, SPG13, chaperonin 60
Source: HGNC:5261
Biotype: protein coding gene
Smarca4
(Mus musculus)Gene
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Synonyms: brahma related gene 1, brg-1, Brg1, b2b508.1Clo, b2b692Clo, SW1/SNF, Mutant line 692, SNF2beta, Mutant line 508, subline 1
Source: MGI:88192
Biotype: protein coding gene
RUNX1
(Homo sapiens)Gene
Name: RUNX family transcription factor 1
Synonyms: acute myeloid leukemia 1 protein, AML1-EVI-1, mutant RUNX1, AML1-EVI-1 fusion protein, EVI-1, PEBP2aB, AMLCR1, oncogene AML-1, PEBP2alpha, AML1, PEBP2-alpha B, SL3-3 enhancer factor 1 alpha B subunit, SL3/AKV core-binding factor alpha B subunit, runt related transcription factor 1, CBF2alpha, CBFA2, core-binding factor, runt domain, alpha subunit 2, PEA2-alpha B, polyomavirus enhancer-binding protein 2 alpha B subunit, runt-related transcription factor 1, AML1-ETO fusion
Source: HGNC:10471
Biotype: protein coding gene
DNA2
(Saccharomyces cerevisiae)Gene
Name: DNA synthesis defective
Synonyms: YHR164C, WEB2
Source: SGD:S000001207
Biotype: protein coding gene
rad-51
(Caenorhabditis elegans)Gene
Name: RADiation sensitivity abnormal/yeast RAD-related 51
Synonyms: Y43C5A.6, rad51, CELE_Y43C5A.6, rdh-1
Source: WB:WBGene00004297
Biotype: protein coding gene
RAD50
(Saccharomyces cerevisiae)Gene
Name: RADiation sensitive
Synonyms: YNL250W
Source: SGD:S000005194
Biotype: protein coding gene