Version: 8.0.0
Date: Tue Jan 28 2025
Ntrk2
Rattus norvegicusRGD:3213
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Ntrk2

Species
Rattus norvegicus
Symbol
Ntrk2
Name
neurotrophic receptor tyrosine kinase 2
Synonyms
  • BDNF/NT-3 growth factors receptor
  • GP145-TrkB/GP95-TrkB
Biotype
protein coding gene
Automated Description
Enables several functions, including brain-derived neurotrophic factor binding activity; brain-derived neurotrophic factor receptor activity; and protein homodimerization activity. Involved in several processes, including brain-derived neurotrophic factor receptor signaling pathway; positive regulation of cell communication; and regulation of neuron projection development. Acts upstream of or within positive regulation of glucocorticoid receptor signaling pathway. Located in several cellular components, including dendritic spine; distal axon; and perikaryon. Is active in glutamatergic synapse; postsynaptic membrane; and presynapse. Used to study glaucoma. Biomarker of several diseases, including alcohol use disorder; anxiety disorder (multiple); attention deficit hyperactivity disorder; borna disease; and nicotine dependence. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; autistic disorder; developmental and epileptic encephalopathy 58; heroin dependence; and morbid obesity. Orthologous to human NTRK2 (neurotrophic receptor tyrosine kinase 2).
RGD Description
Enables several functions, including brain-derived neurotrophic factor binding activity; brain-derived neurotrophic factor receptor activity; and protein homodimerization activity. Involved in several processes, including brain-derived neurotrophic factor receptor signaling pathway; positive regulation of cell communication; and regulation of neuron projection development. Acts upstream of or within positive regulation of glucocorticoid receptor signaling pathway. Located in several cellular components, including dendritic spine; distal axon; and perikaryon. Is active in glutamatergic synapse; postsynaptic membrane; and presynapse. Used to study glaucoma. Biomarker of several diseases, including alcohol use disorder; anxiety disorder (multiple); attention deficit hyperactivity disorder; borna disease; and depressive disorder. Human ortholog(s) of this gene implicated in Alzheimer's disease; autistic disorder; developmental and epileptic encephalopathy 58; major depressive disorder; and morbid obesity. Orthologous to human NTRK2 (neurotrophic receptor tyrosine kinase 2); PARTICIPATES IN brain-derived neurotrophic factor signaling pathway; mitogen activated protein kinase signaling pathway; neurotrophic factor signaling pathway; INTERACTS WITH (+)-pilocarpine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24416
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensNTRK210 of 10YesYes☑☑☑☑☑☑☑☑☑☑  
Mus musculusNtrk29 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Xenopus tropicalisntrk23 of 9YesYes☑ ☐☐☐☑☐☐☑☐  
Danio reriontrk2b9 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Danio reriontrk2a9 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Ntrk3190063524 of 9☑☐☑☐☐☐☑☑☐ 
Ntrk1284562484 of 9☑☐☑☐☐☐☑☑☐ 
Ddr2398441273 of 9☑☐☐☐☐☐☑☑☐ 
Musk489742284 of 9☑☐☑☐☐☐☑☑☐ 
Insrr5107736243 of 9☑☐☐☐☐☐☑☑☐ 
Epha36104037233 of 9☑☐☐☐☐☐☑☑☐ 
Fgfr2795140243 of 9☑☐☐☐☐☐☑☑☐ 
Epha68109734222 of 9☐☐☐☐☐☐☑☑☐ 
Fgfr1992540253 of 9☑☐☐☐☐☐☑☑☐ 
Epha510101437233 of 9☑☐☐☐☐☐☑☑☐ 
Met1195338232 of 9☑☐☐☐☐☐☑☐☐ 
Insr1285141263 of 9☑☐☐☐☐☐☑☑☐ 
Epha41387240253 of 9☑☐☐☐☐☐☑☑☐ 
Ror21484540273 of 9☑☐☐☐☐☐☑☑☐ 
Ret1586738263 of 9☑☐☐☐☐☐☑☑☐ 
Alk1684739273 of 9☑☐☐☐☐☐☑☑☐ 
Tek1786540262 of 9☑☐☐☐☐☐☑☐☐ 
Axl1887838253 of 9☑☐☐☐☐☐☑☑☐ 
Igf1r1979541273 of 9☑☐☐☐☐☐☑☑☐ 
Mst1r2090638242 of 9☑☐☐☐☐☐☑☐☐ 
Pdgfra2194036232 of 9☑☐☐☐☐☐☑☐☐ 
Kdr2290937232 of 9☑☐☐☐☐☐☑☐☐ 
Fgfr42376242283 of 9☑☐☐☐☐☐☑☑☐ 
Mertk2486439233 of 9☑☐☐☐☐☐☑☑☐ 
Ephb12582939243 of 9☑☐☐☐☐☐☑☑☐ 
Flt42695233213 of 9☑☐☐☐☐☐☑☑☐ 
Ror12776240283 of 9☑☐☐☐☐☐☑☑☐ 
Tyro32884137243 of 9☑☐☐☐☐☐☑☑☐ 
Fgfr32969046283 of 9☑☐☐☐☐☐☑☑☐ 
Erbb43089836222 of 9☑☐☐☐☐☐☑☐☐ 
Ros13176240263 of 9☑☐☐☐☐☐☑☑☐ 
Flt33288036222 of 9☑☐☐☐☐☐☑☐☐ 
Pdgfrb3385537232 of 9☑☐☐☐☐☐☑☐☐ 
Erbb33487636222 of 9☑☐☐☐☐☐☑☐☐ 
Csf1r3578139262 of 9☑☐☐☐☐☐☑☐☐ 
Epha13681237242 of 9☑☐☐☐☐☐☑☐☐ 
Ephb43775841252 of 9☑☐☐☐☐☐☑☐☐ 
Kit3884536232 of 9☑☐☐☐☐☐☑☐☐ 
Epha83977539252 of 9☑☐☐☐☐☐☑☐☐ 
Erbb24083336222 of 9☑☐☐☐☐☐☑☐☐ 
Tie14170240273 of 9☑☐☐☐☐☐☑☑☐ 
Egfr4284336222 of 9☑☐☐☐☐☐☑☐☐ 
Flt14371740262 of 9☑☐☐☐☐☐☑☐☐ 
Ephb34471539252 of 9☑☐☐☐☐☐☑☐☐ 
Ddr14552647343 of 9☑☐☐☐☐☐☑☑☐ 
Epha24654145283 of 9☑☐☐☐☐☐☑☑☐ 
Epha74751146313 of 9☑☐☐☐☐☐☑☑☐ 
Ryk4856144262 of 9☑☐☐☐☐☐☑☐☐ 
Epha104955839253 of 9☑☐☐☐☐☐☑☑☐ 
Ephb25043851312 of 9☑☐☐☐☐☐☑☐☐ 
Ltk5133156373 of 9☑☐☐☐☐☐☑☑☐ 
Ephb65245643272 of 9☑☐☐☐☐☐☑☐☐ 
Lmtk25343444282 of 9☑☐☐☐☐☐☑☐☐ 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
References
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    Alleles and Variants

    No mapped variant information available
    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
    NC_051352.1:g.5850138C>Gvariant
    SNP
    • intron variant
    NC_051352.1:g.5852002G>Avariant
    SNP
    • intron variant
    NC_051352.1:g.5867330G>Avariant
    SNP
    • intron variant
    NC_051352.1:g.5593072T>Cvariant
    SNP
    • intron variant
    NC_051352.1:g.5586520A>Gvariant
    SNP
    • intron variant
    NC_051352.1:g.5603867T>Gvariant
    SNP
    • intron variant
    NC_051352.1:g.5683359G>Avariant
    SNP
    • intron variant
    NC_051352.1:g.5653802A>Gvariant
    SNP
    • intron variant
    NC_051352.1:g.5655219G>Avariant
    SNP
    • intron variant
    NC_051352.1:g.5659256C>Gvariant
    SNP
    • intron variant
    Showing 1 - 10 of 1,246 rows
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    View detailed Alleles/Variants information
    Download all Alleles/Variants for all genes of the species

    Transgenic Alleles

    No data available

    Models

    No data available

    Sequence Feature Viewer

    Genome location
    Assembly version
    mRatBN7.2
    Viewer Help
    Data currently unavailable; sequence viewer under construction

    Sequence Details

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    Expression

    Primary Sources
    None
    Other Sources
    Must provide at least one subject
    Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

    Molecular Interactions

    35 interactor genes based on 50 annotations
    Ntrk2 molecule type
    Interactor gene
    Interactor species
    Interactor molecule type
    Detection methods
    Source
    Reference
    protein
    		AppRattus norvegicus
    protein
    • proximity ligation assay
    		PMID:28197073
    protein
    		BDNFHomo sapiens
    protein
    • affinity chromatography technology
    		PMID:1645620
    protein
    		BdnfRattus norvegicus
    protein
    • affinity chromatography technology
    		PMID:27494324
    protein
    		Cdk5Rattus norvegicus
    protein
    • protein kinase assay
    		PMID:17341134
    protein
    		Cdk5Rattus norvegicus
    protein
    • protein kinase assay
    		PMID:17341134
    protein
    		FntaRattus norvegicus
    protein
    • anti tag coimmunoprecipitation
    		PMID:18957540
    protein
    		FntaRattus norvegicus
    protein
    • pull down
    		PMID:18957540
    protein
    		FntaRattus norvegicus
    protein
    • pull down
    		PMID:18957540
    protein
    		FntaRattus norvegicus
    protein
    • anti bait coimmunoprecipitation
    		PMID:18957540
    protein
    		Gipc1Rattus norvegicus
    protein
    • two hybrid
    		PMID:11251075
    Showing 1 - 10 of 50 rows
    per page

    Genetic Interactions

    No data available