Version: 8.0.0Date: Tue Jan 28 2025
Gene Biological Process: response to amyloid-beta
APP
(Homo sapiens)Gene
Name: amyloid beta precursor protein
Synonyms: AAA, ABETA, PN-II, beta-amyloid peptide(1-42), beta-amyloid peptide, preA4, beta-amyloid peptide(1-40), cerebral vascular amyloid peptide, testicular tissue protein Li 2, peptidase nexin-II, alpha-sAPP, AD1, alzheimer disease amyloid protein, amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease), protease nexin-II, CTFgamma, amyloid beta A4 protein, PN2, APPI, alzheimer disease amyloid A4 protein homolog, CVAP, ABPP
Source: HGNC:620
Biotype: protein coding gene
TNF
(Homo sapiens)Gene
Name: tumor necrosis factor
Synonyms: DIF, tumor necrosis factor ligand superfamily member 2, TNF-a, TNF-alpha, tumor necrotic factor alpha, TNLG1F, TNFSF2, tumor necrosis factor-alpha, TNF, monocyte-derived, TNFA, TNF, macrophage-derived, tumor necrosis factor alpha, tumor necrosis factor ligand 1F, IMD127, TNF superfamily, member 2, APC1 protein, cachectin
Source: HGNC:11892
Biotype: protein coding gene
Tnf
(Mus musculus)Gene
Name: tumor necrosis factor
Synonyms: DIF, tumor necrosis factor-alpha, Tnfa, TNF alpha, TNF-alpha, TNFalpha, tumor necrosis factor, alpha, Tnfsf1a, RATTNF
Source: MGI:104798
Biotype: protein coding gene
SIRT1
(Homo sapiens)Gene
Name: sirtuin 1
Synonyms: SIR2-like protein 1, NAD-dependent protein deacylase sirtuin-1, SIR2alpha, SIR2, sir2-like 1, sirtuin, SIR2L1, NAD-dependent protein deacetylase sirtuin-1, regulatory protein SIR2 homolog 1, hSIRT1, hSIR2, sirtuin type 1, NAD-dependent deacetylase sirtuin-1
Source: HGNC:14929
Biotype: protein coding gene
App
(Mus musculus)Gene
Name: amyloid beta precursor protein
Synonyms: Cvap, Abeta, Alzheimer disease amyloid beta protein, cerebrovascular amyloid peptide, protease nexin II, expressed sequence AL024401, AL024401, RIKEN cDNA E030013M08 gene, betaAPP, E030013M08Rik, Adap, appican
Source: MGI:88059
Biotype: protein coding gene
Tlr4
(Mus musculus)Gene
Name: toll-like receptor 4
Synonyms: lipopolysaccharide response, RAS-like, family 2, locus 8, Rasl2-8, Lps
Source: MGI:96824
Biotype: protein coding gene
Mmp2
(Mus musculus)Gene
Name: matrix metallopeptidase 2
Synonyms: GelA, MMP-2, collagenase IVA, basement membrane, 72 kDa, gelatinase A, Clg4a, 72kDa type IV collagenase, 72kDa gelatinase
Source: MGI:97009
Biotype: protein coding gene
CACNA1A
(Homo sapiens)Gene
Name: calcium voltage-gated channel subunit alpha1 A
Synonyms: EIEE42, SCA6, voltage-dependent P/Q-type calcium channel subunit alpha-1A, HPCA, BI, CACNL1A4, FHM, brain calcium channel 1, calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, CAV2.1, calcium channel, L type, alpha-1 polypeptide, APCA, MHP, brain calcium channel I, voltage-gated calcium channel subunit alpha Cav2.1, fetal brain Ca2+ voltage-gated channel alpha1A pore-forming subunit, calcium channel, voltage-dependent, alpha 1a subunit, EA2, MHP1, DEE42
Source: HGNC:1388
Biotype: protein coding gene
MMP2
(Homo sapiens)Gene
Name: matrix metallopeptidase 2
Synonyms: matrix metalloproteinase-2, matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase), TBE-1, CLG4, matrix metalloproteinase 2 (gelatinase a, 72kda gelatinase, 72kda type iv collagenase), 72 kDa gelatinase, collagenase type IV-A, MONA, MMP-2, matrix metalloproteinase-II, CLG4A, gelatinase A, MMP-II, 72 kDa type IV collagenase, neutrophil gelatinase
Source: HGNC:7166
Biotype: protein coding gene
PSEN1
(Homo sapiens)Gene
Name: presenilin 1
Synonyms: AD3, presenilin-1 isoform I-467, PS-1, FAD, ACNINV3, familial Alzheimer Disease, CMD1U, presenilin 1 (Alzheimer disease 3), presenilin-1, PSNL1, S182, PS1
Source: HGNC:9508
Biotype: protein coding gene
IGF1R
(Homo sapiens)Gene
Name: insulin like growth factor 1 receptor
Synonyms: MGC18216, IGF-I receptor, insulin-like growth factor 1 receptor, IGFIR, MGC142170, IGFR, JTK13, MGC142172, soluble IGF1R variant 2, insulin-like growth factor I receptor, soluble IGF1R variant 1, CD221
Source: HGNC:5465
Biotype: protein coding gene
TLR4
(Homo sapiens)Gene
Name: toll like receptor 4
Synonyms: TLR-4, hToll, CD284, ARMD10, homolog of Drosophila toll, TOLL, toll-like receptor 4
Source: HGNC:11850
Biotype: protein coding gene
Sirt1
(Mus musculus)Gene
Name: sirtuin 1
Synonyms: Sir2, expressed sequence AA673258, AA673258, Sir2alpha
Source: MGI:2135607
Biotype: protein coding gene
Fcgr2b
(Mus musculus)Gene
Name: Fc receptor, IgG, low affinity IIb
Synonyms: LyM-1, Fc[g]RII, RIKEN cDNA F630109E10 gene, lymphocyte antigen 17, Fcr-3, Fcr-2, AI528646, FcgRII, CD32, Ly-17, Fcgr2a, Fcgr2, Fc gamma RIIB, F630109E10Rik, Lym-1, Ly-m20, FcgammaRIIB2, expressed sequence AI528646, FCRII, lymphocyte antigen m20, Fc receptor, IgG, low affinity IIa, FcgammaRIIB, Fc-gamma receptor 2, Fc receptor, IgG, low affinity II, Fc-gamma receptor 3
Source: MGI:95499
Biotype: protein coding gene
Gsk3b
(Mus musculus)Gene
Name: glycogen synthase kinase 3 beta
Synonyms: expressed sequence C86142, GSK-3beta, GSK3, RIKEN cDNA 8430431H08 gene, RIKEN cDNA 7330414F15 gene, GSK-3, 7330414F15Rik, C86142, 8430431H08Rik
Source: MGI:1861437
Biotype: protein coding gene
ICAM1
(Homo sapiens)Gene
Name: intercellular adhesion molecule 1
Synonyms: P3.58, BB2, human rhinovirus receptor, intercellular adhesion molecule 1 (CD54), human rhinovirus receptor, ICAM-1, major group rhinovirus receptor, cell surface glycoprotein P3.58, CD54
Source: HGNC:5344
Biotype: protein coding gene
Epha4
(Mus musculus)Gene
Name: Eph receptor A4
Synonyms: AI385584, RGD1560587, Hek8, 2900005C20Rik, rb, Cek8, expressed sequence AI385584, RIKEN cDNA 2900005C20 gene, segmentation receptor tyrosine kinase, Tyro1, rabbit, Sek, Sek1
Source: MGI:98277
Biotype: protein coding gene
Fyn
(Mus musculus)Gene
Name: Fyn proto-oncogene
Synonyms: expressed sequence AW552119, AW552119, AI448320, Src Kinase p59, expressed sequence AI448320
Source: MGI:95602
Biotype: protein coding gene
Ager
(Mus musculus)Gene
Name: advanced glycosylation end product-specific receptor
Synonyms: RAGE
Source: MGI:893592
Biotype: protein coding gene
Tnf
(Rattus norvegicus)Gene
Name: tumor necrosis factor
Synonyms: tumor necrosis factor ligand superfamily member 2, TNF-a, TNF-alpha, tumor necrosis factor (TNF superfamily, member 2), MGC124630, RATTNF, tumor necrosis factor-alpha, Tnfa, tumor necrosis factor-like, tumor necrosis factor alpha, tumor necrosis factor superfamily member 2, tumor necrosis factor superfamily, member 2, LOC103694380, cachectin
Source: RGD:3876
Biotype: protein coding gene
NTRK1
(Homo sapiens)Gene
Name: neurotrophic receptor tyrosine kinase 1
Synonyms: tropomyosin receptor kinase A, Oncogene TRK, TRK1, tropomyosin-related kinase A, trk precursor, TRK1-transforming tyrosine kinase protein, TRK, gp140trk, neurotrophic tyrosine kinase, receptor, type 1, high affinity nerve growth factor receptor, TRKA, Trk-A, DKFZp781I14186, tyrosine kinase receptor A, p140-TrkA, MTC
Source: HGNC:8031
Biotype: protein coding gene
Parp1
(Mus musculus)Gene
Name: poly (ADP-ribose) polymerase family, member 1
Synonyms: poly (ADP-ribose) polymerase, Adprt1, Parp-1, expressed sequence AI893648, Adprp, PARP, ARTD1, sPARP-1, Adprt, AI893648, RIKEN cDNA 5830444G22 gene, parp-1, 5830444G22Rik, C80510, expressed sequence C80510, ADP-ribosyltransferase (NAD+, poly (ADP-ribose) polymerase) 1
Source: MGI:1340806
Biotype: protein coding gene
IGF1
(Homo sapiens)Gene
Name: insulin like growth factor 1
Synonyms: IGF-I, IGFI, insulin-like growth factor I, IGF-IB, IGF-IA, insulin-like growth factor 1 (somatomedin C), IGF, mechano growth factor, MGF, somatomedin-C, insulin-like growth factor IA, insulin-like growth factor IB, insulin-like growth factor 1, IGF1A
Source: HGNC:5464
Biotype: protein coding gene
GRIN1
(Homo sapiens)Gene
Name: glutamate ionotropic receptor NMDA type subunit 1
Synonyms: NDHMSR, glutamate [NMDA] receptor subunit zeta 1, glutamate receptor, ionotropic, N-methyl D-aspartate 1, GluN1, putative NMDtranscript(altAcc_e2), NR1, NMDAR1, glutamate [NMDA] receptor subunit zeta-1, glutamate receptor ionotropic, NMDA 1, N-methyl-D-aspartate receptor subunit NR1, NMD-R1, N-methyl-D-aspartate receptor channel, subunit zeta-1, NDHMSD, NMDA1, DEE101, MRD8
Source: HGNC:4584
Biotype: protein coding gene
CHRNA7
(Homo sapiens)Gene
Name: cholinergic receptor nicotinic alpha 7 subunit
Synonyms: neuronal acetylcholine receptor protein, alpha-7 chain, NACHRA7, a7 nicotinic acetylcholine receptor, acetylcholine receptor, nicotinic, alpha 7 (neuronal), neuronal acetylcholine receptor subunit alpha-7, CHRNA7-2, cholinergic receptor, nicotinic, alpha polypeptide 7, cholinergic receptor, nicotinic alpha 7, cholinergic receptor, nicotinic, alpha 7 (neuronal), alpha-7 nicotinic cholinergic receptor subunit, alpha 7 neuronal nicotinic acetylcholine receptor
Source: HGNC:1960
Biotype: protein coding gene
GRM5
(Homo sapiens)Gene
Name: glutamate metabotropic receptor 5
Synonyms: mGlu5, glutamate receptor, metabotropic 5, metabotropic glutamate receptor 5 variant H, metabotropic glutamate receptor 5, metabotropic glutamate receptor 5 variant G, MGLUR5, GRM5 variant 9, PPP1R86, metabotropic glutamate receptor 5 variant F, GPRC1E
Source: HGNC:4597
Biotype: protein coding gene
GJA1
(Homo sapiens)Gene
Name: gap junction protein alpha 1
Synonyms: EKVP, gap junction membrane channel protein alpha 1, PPKCA, CMDR, gap junction alpha-1 protein, HSS, gap junction protein, alpha-like, CX43, GJAL, connexin-43, AVSD3, gap junction protein, alpha 1, 43kDa, ODDD, DFNB38, HLHS1, EKVP3, connexin 43, gap junction 43 kDa heart protein
Source: HGNC:4274
Biotype: protein coding gene
Cd36
(Mus musculus)Gene
Name: CD36 molecule
Synonyms: Cd36-ps1, Scarb3, CD36/FAT, RGD1565355, RGD1562323, FAT, Fat, fatty acid translocase
Source: MGI:107899
Biotype: protein coding gene
FYN
(Homo sapiens)Gene
Name: FYN proto-oncogene, Src family tyrosine kinase
Synonyms: p59-FYN, protein-tyrosine kinase fyn, proto-oncogene c-Fyn, c-syn protooncogene, FYN oncogene related to SRC, FGR, YES, tyrosine kinase p59fyn(T), SYN, tyrosine-protein kinase Fyn, src/yes-related novel, SLK, OKT3-induced calcium influx regulator, proto-oncogene Syn, MGC45350, proto-oncogene tyrosine-protein kinase fyn, src-like kinase
Source: HGNC:4037
Biotype: protein coding gene
PARP1
(Homo sapiens)Gene
Name: poly(ADP-ribose) polymerase 1
Synonyms: poly (ADP-ribose) polymerase 1, ADP-ribosyltransferase (NAD+, poly (ADP-ribose) polymerase), poly(ADP-ribose) polymerase, PARP, ARTD1, ADPRT 1, ADPRT1, PARP-1, NAD(+) ADP-ribosyltransferase 1, Poly-PARP, poly(ADP-ribosyl)transferase, pADPRT-1, DNA ADP-ribosyltransferase PARP1, poly [ADP-ribose] polymerase 1, ADP-ribosyltransferase NAD(+), PARS, poly (ADP-ribose) polymerase family, member 1, PPOL, ADP-ribosyltransferase diphtheria toxin-like 1, poly[ADP-ribose] synthase 1, ADPRT, poly(ADP-ribose) synthetase
Source: HGNC:270
Biotype: protein coding gene
Grin1
(Rattus norvegicus)Gene
Name: glutamate ionotropic receptor NMDA type subunit 1
Synonyms: neurotransmitter receptor, N-methyl-D-aspartate receptor subunit NR1, N-methyl-D-aspartate glutamate receptor, NMD-R1, glutamate receptor, ionotropic, N-methyl D-aspartate 1, N-methyl-D-aspartate receptor, GluN1, NR1, NMDAR1, NMDA R1 receptor C1 cassette, glutamate [NMDA] receptor subunit zeta-1, glutamate receptor ionotropic, NMDA 1
Source: RGD:2736
Biotype: protein coding gene
Psen1
(Mus musculus)Gene
Name: presenilin 1
Synonyms: alzheimer disease 3 homolog, PS-1, Ad3h, S182, presenilin-1, PS1
Source: MGI:1202717
Biotype: protein coding gene
ADRB2
(Homo sapiens)Gene
Name: adrenoceptor beta 2
Synonyms: beta-2 adrenoceptor, BETA2AR, adrenergic receptor, beta 2, ADRBR, beta-2 adrenergic receptor, BAR, adrenoceptor beta 2, surface, catecholamine receptor, ADRB2R, adrenoceptor beta 2 surface, beta-2 adrenoreceptor, adrenergic, beta-2-, receptor, surface, ARB2, B2AR
Source: HGNC:286
Biotype: protein coding gene
Lrp1
(Mus musculus)Gene
Name: low density lipoprotein receptor-related protein 1
Synonyms: Mutant line 1554, b2b1554Clo, alpha-2-macroglobulin receptor, AI316852, CD91, expressed sequence AI316852, A2mr, LRP-1
Source: MGI:96828
Biotype: protein coding gene
CACNA1B
(Homo sapiens)Gene
Name: calcium voltage-gated channel subunit alpha1 B
Synonyms: calcium channel, N type, NEDNEH, voltage-gated calcium channel alpha subunit Cav2.2, CACNL1A5, voltage-dependent N-type calcium channel subunit alpha-1B, DYT23, CACNN, brain calcium channel III, calcium channel, L type, alpha-1 polypeptide, Cav2.2 voltage-gated Ca2+ channel, voltage-gated calcium channel subunit alpha Cav2.2, calcium channel alpha12.2 subunit, calcium channel, voltage-dependent, alpha 1B subunit, N type, calcium channel, voltage-dependent, L type, alpha 1B subunit, BIII, calcium channel, voltage-dependent, N type, alpha 1B subunit, Cav2.2
Source: HGNC:1389
Biotype: protein coding gene
Adrb2
(Mus musculus)Gene
Name: adrenergic receptor, beta 2
Synonyms: beta 2-AR, Gpcr7, B-adrenergic binding, beta 2-adrenoceptor, Badm, Adrb-2, G protein coupled receptor 7
Source: MGI:87938
Biotype: protein coding gene
Psen1
(Rattus norvegicus)Gene
Name: presenilin 1
Synonyms: PS-1, presenilin-1
Source: RGD:3425
Biotype: protein coding gene
Vcam1
(Mus musculus)Gene
Name: vascular cell adhesion molecule 1
Synonyms: VCAM1B, CD106, Vcam-1
Source: MGI:98926
Biotype: protein coding gene
Gja1
(Mus musculus)Gene
Name: gap junction protein, alpha 1
Synonyms: expressed sequence AU042049, AU042049, Cx43alpha1, AW546267, alpha 1 connexin, Cx43, connexin43, Cxnk1, Gja-1, connexin 43, expressed sequence AW546267, Cnx43
Source: MGI:95713
Biotype: protein coding gene
Igf1
(Mus musculus)Gene
Name: insulin-like growth factor 1
Synonyms: RIKEN cDNA C730016P09 gene, Igf-I, C730016P09Rik, Igf-1, IGF
Source: MGI:96432
Biotype: protein coding gene
Trem2
(Mus musculus)Gene
Name: triggering receptor expressed on myeloid cells 2
Synonyms: Trem2-Mia, Trem2-Mib, triggering receptor expressed on myeloid cells 2c, triggering receptor expressed on myeloid cells 2b, triggering receptor expressed on myeloid cells 2a, Trem2a, Trem2c, Trem2b
Source: MGI:1913150
Biotype: protein coding gene
Cacna1a
(Mus musculus)Gene
Name: calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
Synonyms: smrl, rocker, calcium channel alpha 1a, BccA1, SCA6, rbA-1, alpha1A, nmf352, neuroscience mutagenesis facility, 352, Ccha1a, tg, tottering, la, rkr, Cacnl1a4, leaner, Cav2.1, small roller
Source: MGI:109482
Biotype: protein coding gene
FOXO3
(Homo sapiens)Gene
Name: forkhead box O3
Synonyms: FOXO3A-, MGC12739, AF6q21, forkhead homolog (rhabdomyosarcoma) like 1, FKHRL1, DKFZp781A0677, forkhead in rhabdomyosarcoma-like 1, FOXO2, forkhead box O3A, forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1, forkhead box protein O3, MGC31925, FOXO3A, FKHRL1P2
Source: HGNC:3821
Biotype: protein coding gene
Bcl2
(Rattus norvegicus)Gene
Name: BCL2, apoptosis regulator
Synonyms: Bcl-2, B cell lymphoma 2 associated oncogene, Bcl-2alpha, ENSRNOG00000067693, B-cell CLL/lymphoma 2, Bcl2-like protein, apoptosis regulator Bcl-2, B-cell leukemia/lymphoma 2, B cell leukemia/lymphoma 2
Source: RGD:2199
Biotype: protein coding gene
Icam1
(Rattus norvegicus)Gene
Name: intercellular adhesion molecule 1
Synonyms: ICAM, ICAM-1, CD54
Source: RGD:2857
Biotype: protein coding gene
Syk
(Mus musculus)Gene
Name: spleen tyrosine kinase
Synonyms: p72syk, Sykb
Source: MGI:99515
Biotype: protein coding gene
App
(Rattus norvegicus)Gene
Name: amyloid beta precursor protein
Synonyms: amyloid beta (A4) precursor protein, Abeta, amyloid beta A4 protein, AG, alzheimer disease amyloid A4 protein homolog, amyloidogenic glycoprotein, amyloid A4, ABPP
Source: RGD:2139
Biotype: protein coding gene
Cacna2d1
(Mus musculus)Gene
Name: calcium channel, voltage-dependent, alpha2/delta subunit 1
Synonyms: Cacna2, CCHLA2, DHSCCA, Ca(v)alpha2delta1, calcium channel, L type, 2A subunit, Cchl2a, calcium channel, voltage-dependent, L type, alpha 2 delta subunit
Source: MGI:88295
Biotype: protein coding gene
Mapk9
(Rattus norvegicus)Gene
Name: mitogen-activated protein kinase 9
Synonyms: c-Jun N-terminal kinase 2, MAPK 9, p54-alpha, stress-activated protein kinase JNK2, stress activated protein kinase alpha II, SAPK, MAP kinase 9, SAPK-alpha
Source: RGD:628847
Biotype: protein coding gene
Prnp
(Mus musculus)Gene
Name: prion protein
Synonyms: prion protein, structural locus, CD230, expressed sequence AA960666, PrPSc, expressed sequence AI325101, prion protein, scrapie incubation time regulation, Sinc, Prn, PrP, PrPC, Prn-p, Prn-i, scrapie incubation period, AA960666, AI325101
Source: MGI:97769
Biotype: protein coding gene