Version: 8.0.0Date: Tue Jan 28 2025
Gene Diseases: lung non-small cell carcinoma
TP53
(Homo sapiens)Gene
Name: tumor protein p53
Synonyms: cellular tumor antigen p53, tumor supressor p53, BCC7, transformation-related protein 53, p53 transformation suppressor, antigen NY-CO-13, mutant tumor protein 53, P53, phosphoprotein p53, p53 antigen, FLJ92943, TRP53, mutant p53 protein, tumor protein 53, tumor suppressor TP53, tumor suppressor p53, LFS1, p53 tumor suppressor, BMFS5, truncated p53 protein
Source: HGNC:11998
Biotype: protein coding gene
Pten
(Mus musculus)Gene
Name: phosphatase and tensin homolog
Synonyms: B430203M17Rik, RIKEN cDNA B430203M17 gene, expressed sequence AI463227, RIKEN cDNA 2310035O07 gene, TEP1, Mmac, A130070J02Rik, MMAC1, AI463227, 2310035O07Rik, RIKEN cDNA A130070J02 gene
Source: MGI:109583
Biotype: protein coding gene
ATM
(Homo sapiens)Gene
Name: ATM serine/threonine kinase
Synonyms: serine/threonine kinase ATM, TEL1, telomere maintenance 1, homolog, MGC74674, human phosphatidylinositol 3-kinase homolog, ATDC, truncated ATM serine/threonine kinase, DKFZp781A0353, ATA, AT mutated, ATC, ataxia telangiectasia mutated, ATD, TEL1, ataxia telangiectasia mutated (includes complementation groups A, C and D), ATE, A-T mutated, serine-protein kinase ATM, TELO1, AT1
Source: HGNC:795
Biotype: protein coding gene
BRCA1
(Homo sapiens)Gene
Name: BRCA1 DNA repair associated
Synonyms: RNF53, early onset breast cancer 1, truncated breast and ovarian cancer susceptibility protein 1, truncated breast cancer 1, BRCC1, BRCA1, DNA repair associated, RING finger protein 53, breast and ovarian cancer susceptibility protein 1, BRCA1/BRCA2-containing complex, subunit 1, breast cancer 1, early onset, IRIS, Fanconi anemia, complementation group S, breast cancer type 1 susceptibility protein, BRCAI, PNCA4, PSCP, truncated BRCA1, BROVCA1, protein phosphatase 1, regulatory subunit 53, breast cancer 1, PPP1R53, FANCS
Source: HGNC:1100
Biotype: protein coding gene
Trp53
(Mus musculus)Gene
Name: transformation related protein 53
Synonyms: p44, p53
Source: MGI:98834
Biotype: protein coding gene
STAT5B
(Homo sapiens)Gene
Name: signal transducer and activator of transcription 5B
Synonyms: transcription factor STAT5B, STAT5, GHISID2
Source: HGNC:11367
Biotype: protein coding gene
PTEN
(Homo sapiens)Gene
Name: phosphatase and tensin homolog
Synonyms: MHAM, DEC, PTENepsilon, 10q23del, phosphatase and tensin-like protein, PTEN1, mitochondrial PTENalpha, GLM2, PTEN variant PTEN-K267Rfs*9, phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, CWS1, mutated in multiple advanced cancers 1, MMAC1, PTEN variant PTEN-L247*, PTEN variant PTEN-R234Afs*11, mitochondrial phosphatase and tensin protein alpha, TEP1, PTENgama, inositol polyphosphate 3-phosphatase, MMAC1 phosphatase and tensin homolog deleted on chromosome 10, BZS, PTENbeta, phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, MGC11227
Source: HGNC:9588
Biotype: protein coding gene
EGFR
(Homo sapiens)Gene
Name: epidermal growth factor receptor
Synonyms: PIG61, NNCIS, receptor tyrosine-protein kinase erbB-1, epidermal growth factor receptor tyrosine kinase domain, EGFR vIII, proto-oncogene c-ErbB-1, cell growth inhibiting protein 40, erb-b2 receptor tyrosine kinase 1, ERRP, ERBB, epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian), erythroblastic leukemia viral (v-erb-b) oncogene homolog, ERBB1, mENA, avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, cell proliferation-inducing protein 61, NISBD2, HER1
Source: HGNC:3236
Biotype: protein coding gene
TNF
(Homo sapiens)Gene
Name: tumor necrosis factor
Synonyms: DIF, tumor necrosis factor ligand superfamily member 2, TNF-a, TNF-alpha, tumor necrotic factor alpha, TNLG1F, TNFSF2, tumor necrosis factor-alpha, TNF, monocyte-derived, TNFA, TNF, macrophage-derived, tumor necrosis factor alpha, tumor necrosis factor ligand 1F, IMD127, TNF superfamily, member 2, APC1 protein, cachectin
Source: HGNC:11892
Biotype: protein coding gene
MYC
(Homo sapiens)Gene
Name: MYC proto-oncogene, bHLH transcription factor
Synonyms: proto-oncogene c-Myc, avian myelocytomatosis viral oncogene homolog, c-Myc, MYCC, v-myc myelocytomatosis viral oncogene homolog, myc proto-oncogene protein, class E basic helix-loop-helix protein 39, transcription factor p64, bHLHe39, MRTL, cMyc, myc-related translation/localization regulatory factor, v-myc avian myelocytomatosis viral oncogene homolog
Source: HGNC:7553
Biotype: protein coding gene
Ttr
(Mus musculus)Gene
Name: transthyretin
Synonyms: TT, expressed sequence AA408768, AA408768, prealbumin, expressed sequence AI787086, expressed sequence D17860, Tbpa, Lr1, AI787086, D17860
Source: MGI:98865
Biotype: protein coding gene
Mir223
(Mus musculus)Gene
Name: microRNA 223
Synonyms: miR-223, mmu-mir-223, Mirn223
Source: MGI:2684360
Biotype: miRNA gene
aap-1
(Caenorhabditis elegans)Gene
Name: phosphoinositide kinase AdAPter subunit 1
Synonyms: CELE_Y110A7A.10, Y110A7A.10
Source: WB:WBGene00000001
Biotype: protein coding gene
ERCC5
(Homo sapiens)Gene
Name: ERCC excision repair 5, endonuclease
Synonyms: xeroderma pigmentosum, complementation group G, ERCC5-201, UVDR, ERCM2, xeroderma pigmentosum group G-complementing protein, XPG, COFS3, excision repair protein, excision repair cross-complementing rodent repair deficiency, complementation group 5, DNA repair protein complementing XP-G cells, excision repair cross-complementation group 5, XPG-complementing protein, DNA excision repair protein ERCC-5, XPGC, xeroderma pigmentosum complementation group G protein
Source: HGNC:3437
Biotype: protein coding gene
KRAS
(Homo sapiens)Gene
Name: KRAS proto-oncogene, GTPase
Synonyms: KI-RAS, RALD, NS, c-Ki-ras2, cellular c-Ki-ras2 proto-oncogene, PR310 c-K-ras oncogene, KRAS-ENOPH fusion, K-RAS2B, GTPase KRas, K-RAS2A, NS3, K-RAS4B, K-RAS4A, c-Kirsten-ras protein, Kirsten rat sarcoma-2 viral (v-Ki-ras2) oncogene homolog, Kirsten rat sarcoma viral proto-oncogene, c-Ki-ras, Kirsten rat sarcoma viral oncogene homolog, oncogene KRAS2, K-ras p21 protein, RASK2, CFC2, K-Ras, v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, C-K-RAS, K-Ras 2, v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog, OES, cellular transforming proto-oncogene, KRAS2, 'C-K-RAS, proto-oncogene GTPase, transforming protein p21, KRAS1
Source: HGNC:6407
Biotype: protein coding gene
Tnf
(Mus musculus)Gene
Name: tumor necrosis factor
Synonyms: DIF, tumor necrosis factor-alpha, Tnfa, TNF alpha, TNF-alpha, TNFalpha, tumor necrosis factor, alpha, Tnfsf1a, RATTNF
Source: MGI:104798
Biotype: protein coding gene
Stat3
(Mus musculus)Gene
Name: signal transducer and activator of transcription 3
Synonyms: RIKEN cDNA 1110034C02 gene, expressed sequence AW109958, 1110034C02Rik, Aprf, AW109958
Source: MGI:103038
Biotype: protein coding gene
Cdkn1a
(Mus musculus)Gene
Name: cyclin dependent kinase inhibitor 1A
Synonyms: CDKI, Cip1, p21Cip1, P21, Cdkn1, p21, cyclin dependent kinase inhibitor, CIP1, UV96, p21WAF, Waf1, CAP20, SDI1, mda6
Source: MGI:104556
Biotype: protein coding gene
ABCB1
(Homo sapiens)Gene
Name: ATP binding cassette subfamily B member 1
Synonyms: P-GP, ATP-binding cassette, sub-family B (MDR/TAP), member 1, CLCS, ATP-binding cassette sub-family B member 1, ENPAT, PGY1, multidrug resistance protein 1, ATP-binding cassette, subfamily B, member 1, GP170, colchicin sensitivity, ATP-dependent translocase ABCB1, p-170, MDR1, ABC20, MGC163296, P-glycoprotein 1, P glycoprotein, phospholipid transporter ABCB1, doxorubicin resistance, CD243
Source: HGNC:40
Biotype: protein coding gene
SNF1
(Saccharomyces cerevisiae)Gene
Name: Sucrose NonFermenting
Synonyms: CCR1, PAS14, CAT1, GLC2, HAF3, YDR477W
Source: SGD:S000002885
Biotype: protein coding gene
let-23
(Caenorhabditis elegans)Gene
Name: LEThal 23
Synonyms: CELE_ZK1067.1, ZK1067.1, kin-7
Source: WB:WBGene00002299
Biotype: protein coding gene
ERCC2
(Homo sapiens)Gene
Name: ERCC excision repair 2, TFIIH core complex helicase subunit
Synonyms: general transcription and DNA repair factor IIH helicase subunit XPD, TTD, TFIIH basal transcription factor complex 80 kDa subunit, TTD1, TFIIH basal transcription factor complex helicase subunit, COFS2, DNA 5'-3' helicase XPD, XPD, EM9, excision repair cross-complementing rodent repair deficiency, complementation group 2, xeroderma pigmentosum complementary group D, xeroderma pigmentosum group D-complementing protein, BTF2 p80, basic transcription factor 2 80 kDa subunit, trichothiodystrophy, MGC102762, MGC126218, DNA repair protein complementing XP-D cells, TFIIH basal transcription factor complex helicase XPB subunit, MGC126219, excision repair cross-complementation group 2, TFIIH basal transcription factor complex helicase XPD subunit, TFIIH subunit XPD, TFIIH, CXPD, TFIIH p80, TFIIH 80 kDa subunit, DNA excision repair protein ERCC-2
Source: HGNC:3434
Biotype: protein coding gene
MMP2
(Homo sapiens)Gene
Name: matrix metallopeptidase 2
Synonyms: matrix metalloproteinase-2, matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase), TBE-1, CLG4, matrix metalloproteinase 2 (gelatinase a, 72kda gelatinase, 72kda type iv collagenase), 72 kDa gelatinase, collagenase type IV-A, MONA, MMP-2, matrix metalloproteinase-II, CLG4A, gelatinase A, MMP-II, 72 kDa type IV collagenase, neutrophil gelatinase
Source: HGNC:7166
Biotype: protein coding gene
ESR1
(Homo sapiens)Gene
Name: estrogen receptor 1
Synonyms: estrogen receptor alpha E1-E2-1-2, estrogen receptor alpha 3*,4,5,6,7*/822 isoform, estrogen receptor alpha delta 3*,4,5,6,7*,8*/941 isoform, oestrogen receptor alpha, estrogen receptor alpha splice variant, ERalphai67, nuclear receptor subfamily 3 group A member 1, NR3A1, estrogen receptor alpha delta 4 +49 isoform, estrogen receptor alpha delta 3*,4,5,6,7*/819-2 isoform, ESTRR, estrogen receptor alpha splice variant, CTERP-1, estrogen receptor alpha E1-N2-E2-1-2, estrogen receptor alpha splice variant, ERalphaDup5, estradiol receptor, ESR, estrogen receptor, E2 receptor alpha, estrogen receptor alpha splice variant, ERalphai45bL, estrogen nuclear receptor alpha, estrogen receptor alpha splice variant, ERalphai56, ER, estrogen receptor alpha splice variant, ERalphai45c, estrogen receptor alpha splice variant, ERalphai45a, estrogen receptor alpha splice variant, ERalphai45bS, Era, estrogen receptor alpha delta 4*,5,6,7*/654 isoform, estrogen receptor alpha delta 4*,5,6,7,8*/901 isoform, ESRA, ER-alpha, DKFZp686N23123
Source: HGNC:3467
Biotype: protein coding gene
ttr
(Danio rerio)Gene
Name: transthyretin (prealbumin, amyloidosis type I)
Synonyms: zgc:103583
Source: ZFIN:ZDB-GENE-040927-14
Biotype: protein coding gene
Brca1
(Mus musculus)Gene
Name: breast cancer 1, early onset
Synonyms: BRCA-1
Source: MGI:104537
Biotype: protein coding gene
N
(Drosophila melanogaster)Gene
Name: Notch
Synonyms: 16-178, 16-55, RICN, Abruptex, Chp, Co, EG:163A10.2, Confluens, split, anon-EST:Liang-1.12, Ax, dNotch, Nicd, Chopped, Notch, NOTCH, strawberry, clone 1.12, co, spl, shd, 1.1, nd, l(1)3Cb, NICD, CG3936, notchoid, n[fah], notch, fa, NECD, CT13012, EG:140G11.1, facet, l(1)Ax, l(1)N, swb
Source: FB:FBgn0004647
Biotype: protein coding gene
ARID1A
(Homo sapiens)Gene
Name: AT-rich interaction domain 1A
Synonyms: chromatin remodeling factor p250, MRD14, hOSA1, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily f, member 1, C1orf4, brain protein 120, SMARCF1, BM029, AT-rich interactive domain-containing protein 1A, SWI/SNF complex protein p270, osa homolog 1, OSA1, BAF250, SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1, P270, OSA1 nuclear protein, BAF250a, hELD, BRG1-associated factor 250a, ARID domain-containing protein 1A, SWI-like protein, BRG1-associated factor 250, CSS2, AT rich interactive domain 1A (SWI-like), B120, ELD
Source: HGNC:11110
Biotype: protein coding gene
Casp3
(Mus musculus)Gene
Name: caspase 3
Synonyms: RIKEN cDNA A830040C14 gene, Apopain, melody, CC3, A830040C14Rik, Yama, AC-3, CPP32, mldy, CPP32-beta, Lice, Caspase-3
Source: MGI:107739
Biotype: protein coding gene
notch1b
(Danio rerio)Gene
Name: notch receptor 1b
Synonyms: wu:fc55e11, etID309871.5
Source: ZFIN:ZDB-GENE-990415-183
Biotype: protein coding gene
Ezh2
(Mus musculus)Gene
Name: enhancer of zeste 2 polycomb repressive complex 2 subunit
Synonyms: enhancer of zeste homolog (Drosophila), Enx-1, Enx1h, KMT6
Source: MGI:107940
Biotype: protein coding gene
Ctnnb1
(Mus musculus)Gene
Name: catenin beta 1
Synonyms: beta-catenin, beta catenin, Catnb, batface, catenin beta, catenin (cadherin associated protein), beta 1, Bfc
Source: MGI:88276
Biotype: protein coding gene
Lep
(Mus musculus)Gene
Name: leptin
Synonyms: ob, OB, obese
Source: MGI:104663
Biotype: protein coding gene
daf-18
(Caenorhabditis elegans)Gene
Name: abnormal DAuer Formation 18
Synonyms: T07A9.6, CELE_T07A9.6
Source: WB:WBGene00000913
Biotype: protein coding gene
Kras
(Mus musculus)Gene
Name: Kirsten rat sarcoma viral oncogene homolog
Synonyms: Kras-2, expressed sequence AI929937, K-ras, AI929937, c-Ki-ras, Ki-ras, Kirsten rat sarcoma oncogene 2, expressed, p21, Kras2
Source: MGI:96680
Biotype: protein coding gene
Nrp1
(Mus musculus)Gene
Name: neuropilin 1
Synonyms: Npn1, NPN-1, Neuropilin-1, NP-1, Nrp
Source: MGI:106206
Biotype: protein coding gene
Antp
(Drosophila melanogaster)Gene
Name: Antennapedia
Synonyms: ANTC, antp, ANT-C, Nasobemia, Ant, Scx, Antp1, Antenapedia, DMANTPE1, Antp P1, Antp P2, DmAntp, Sex combs extra, CG1028, Aus, BG:DS07700.1, Ns, Sex comb extra, Hu, antennapedia, AntP1, Humeral, ANT-P, DRO15DC96Z, Antennapaedia, Antennapedia P2, AntP, Antennapedia P1, l(3)84Ba, ANTP, 3.4, Dm-Antennapedia, Atennapedia
Source: FB:FBgn0260642
Biotype: protein coding gene
p53
(Drosophila melanogaster)Gene
Name: p53
Synonyms: CG33336, CG10873, dp53, DMP53, Dp53, P53, prac, dmp53, D-p53, Dmp53, Dm-P53, DmP53, dmP53, protein 53, CG31325, p53-like regulator of apoptosis and cell cycle, Drosophila p53
Source: FB:FBgn0039044
Biotype: protein coding gene
hyx
(Drosophila melanogaster)Gene
Name: hyrax
Synonyms: Cdc73, Hyx, Hyrax, hyx/CDC73, CDC73, dCDC73, Parafibromin, CG11990
Source: FB:FBgn0037657
Biotype: protein coding gene
Akt1
(Mus musculus)Gene
Name: thymoma viral proto-oncogene 1
Synonyms: PKB/Akt, PKB, Akt, PKBalpha
Source: MGI:87986
Biotype: protein coding gene
Ptgs2
(Mus musculus)Gene
Name: prostaglandin-endoperoxide synthase 2
Synonyms: COX-2, Cox-2, PHS II, Cox2, Pghs2, cyclooxygenase-2, prostaglandin G/H synthase, PHS-2, COX2, PGHS-2, cyclooxygenase 2, Tis10
Source: MGI:97798
Biotype: protein coding gene
Mmp2
(Mus musculus)Gene
Name: matrix metallopeptidase 2
Synonyms: GelA, MMP-2, collagenase IVA, basement membrane, 72 kDa, gelatinase A, Clg4a, 72kDa type IV collagenase, 72kDa gelatinase
Source: MGI:97009
Biotype: protein coding gene
Bax
(Mus musculus)Gene
Name: BCL2-associated X protein
Synonyms: Not Available
Source: MGI:99702
Biotype: protein coding gene
Il1b
(Mus musculus)Gene
Name: interleukin 1 beta
Synonyms: IL-1F2, IL-1B, IL-1beta, Il-1b
Source: MGI:96543
Biotype: protein coding gene
CDH1
(Homo sapiens)Gene
Name: cadherin 1
Synonyms: BCDS1, LCAM, calcium-dependent adhesion protein, epithelial, cell-CAM 120/80, ECAD, CDHE, cadherin 1, E-cadherin (epithelial), CAM 120/80, UVO, uvomorulin, cadherin 1, type 1, E-cadherin (epithelial), E-cadherin 1, cadherin 1, type 1, E-Cadherin, CD324, cadherin-1, epithelial cadherin, Arc-1, truncated cadherin 1 type 1
Source: HGNC:1748
Biotype: protein coding gene
Drice
(Drosophila melanogaster)Gene
Name: Death related ICE-like caspase
Synonyms: interleukin-1beta-converting enzyme, ice, ICE, Ice, drICE, caspase 3, drIce, drice, DriCE, DrICE, DrIce, Drice, CG7788, crice, DRICE, Drive, caspase-3
Source: FB:FBgn0019972
Biotype: protein coding gene
Sox14
(Drosophila melanogaster)Gene
Name: Sox box protein 14
Synonyms: Dsox-14, CG17263, SOXC, Sox-14, DSox14, DSox-14, sox14, SOX60B, SOX14, sox box protein 14, DSox60B, CG3090
Source: FB:FBgn0005612
Biotype: protein coding gene
Brca1
(Rattus norvegicus)Gene
Name: BRCA1, DNA repair associated
Synonyms: BRCA-1, breast cancer 1, early onset, breast cancer type 1 susceptibility protein homolog, breast cancer 1, RING-type E3 ubiquitin transferase BRCA1
Source: RGD:2218
Biotype: protein coding gene
Tp53
(Rattus norvegicus)Gene
Name: tumor protein p53
Synonyms: cellular tumor antigen p53, tumor protein p53 (Li-Fraumeni syndrome), Trp53, tumor suppressor p53, transformation related protein 53, MGC112612, p53
Source: RGD:3889
Biotype: protein coding gene
Runx1
(Mus musculus)Gene
Name: runt related transcription factor 1
Synonyms: PEBP2-alpha, Pebp2a2, expressed sequence AI462102, AI462102, CBF-alpha-2, Cbfa2, PEA2-alpha, runt domain, alpha subunit 2, core binding factor alpha 2, Aml1, AML1
Source: MGI:99852
Biotype: protein coding gene